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C9JQM9

- C9JQM9_HUMAN

UniProt

C9JQM9 - C9JQM9_HUMAN

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Protein
Submitted name:

Aspartate--tRNA ligase, cytoplasmic

Gene

DARS

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartate-tRNA ligase activity Source: InterPro
  2. ATP binding Source: InterPro
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. aspartyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Aspartate--tRNA ligase, cytoplasmicImported
Gene namesi
Name:DARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2678. DARS.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiC9JQM9.

Expressioni

Gene expression databases

BgeeiC9JQM9.
ExpressionAtlasiC9JQM9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JQM9.
SMRiC9JQM9. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00550000074880.
HOGENOMiHOG000213672.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR018150. aa-tRNA-synt_II-like.
IPR004523. Asp-tRNA_synthase.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF10. PTHR22594:SF10. 1 hit.
PfamiPF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JQM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQSQEKPDR VLVRVRDLTI QKADEVVWVR ARVHTSRAKG KQCFLVLRQQ
60 70 80 90 100
QFNVQALVAV GDHASKQMVK FAANINKESI VDVEGVVRKV NQKIGSCTQQ
110 120 130
DVELHVQKIY VISLAEPRLP LQLDDAVRPE AEGEE
Length:135
Mass (Da):15,282
Last modified:November 3, 2009 - v1
Checksum:i08A6854638AEB3B9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei135 – 1351Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011999 Genomic DNA. No translation available.
AC093391 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000449218; ENSP00000388801; ENSG00000115866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011999 Genomic DNA. No translation available.
AC093391 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali C9JQM9.
SMRi C9JQM9. Positions 1-131.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi C9JQM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000449218 ; ENSP00000388801 ; ENSG00000115866 .

Organism-specific databases

HGNCi HGNC:2678. DARS.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00550000074880.
HOGENOMi HOG000213672.

Miscellaneous databases

ChiTaRSi DARS. human.
NextBioi 35487428.

Gene expression databases

Bgeei C9JQM9.
ExpressionAtlasi C9JQM9. baseline and differential.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR018150. aa-tRNA-synt_II-like.
IPR004523. Asp-tRNA_synthase.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
PANTHERi PTHR22594. PTHR22594. 1 hit.
PTHR22594:SF10. PTHR22594:SF10. 1 hit.
Pfami PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JQM9_HUMAN
AccessioniPrimary (citable) accession number: C9JQM9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3