TFPI

Functionⁱ

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tissue factor pathway inhibitorImported
Gene namesⁱ	Name:TFPIImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000003436.14.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11760. TFPI.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000003436.

OpenTargetsⁱ

ENSG00000003436.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	Sequence analysisAdd BLAST		28
ChainⁱPRO_5014086887	29 – 106	Sequence analysisAdd BLAST		78

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000003436.

Bgeeⁱ

ENSG00000003436.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 104	BPTI/Kunitz inhibitorInterPro annotationAdd BLAST		51

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4295. Eukaryota. ENOG410XQNP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114929.
HOGENOMⁱ	HOG000231818.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109. KU. 1 hit.
Gene3Dⁱ	4.10.410.10. 1 hit.
InterProⁱ	View protein in InterPro IPR002223. Kunitz_BPTI. IPR036880. Kunitz_BPTI_sf. IPR020901. Prtase_inh_Kunz-CS. IPR029864. TFPI1.
PANTHERⁱ	PTHR10083:SF317. PTHR10083:SF317. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00014. Kunitz_BPTI. 1 hit.
PRINTSⁱ	PR00759. BASICPTASE.
SMARTⁱ	View protein in SMART SM00131. KU. 1 hit.
SUPFAMⁱ	SSF57362. SSF57362. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00280. BPTI_KUNITZ_1. 1 hit. PS50279. BPTI_KUNITZ_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

C9JQ14-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM 
        60         70         80         90        100
HSFCAFKADD GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC 

KKMCTR

Length:106

Mass (Da):12,216

Last modified:November 3, 2009 - v1

Checksum:ⁱC94ABD71E05B6455

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	106	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007319 Genomic DNA. No translation available. AC098485 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007319 Genomic DNA. No translation available.
AC098485 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000421427; ENSP00000408170; ENSG00000003436. ENST00000437725; ENSP00000388159; ENSG00000003436.
UCSC genome browser More...UCSCⁱ	uc061qmw.1. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
C9JQ14	P10646 C9JP39 A0A2J8PRV7 A0A2J8PRT0 C9JT76 A0A2J8PRT7 C9J103 A0A2J8PRW3 UPI000002CD4B UPI0003C8C442 +1	Homo sapiens (Human) Pan troglodytes (Chimpanzee)	304	UniRef100_P10646	Cluster: Tissue factor pathway inhibitor	12

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
C9JQ14	P10646 C9JP39 A0A2J8PRV7 A0A2J8PRT0 C9JT76 A0A2J8PRT7 C9J103 A0A2J8PRW3 UPI000002CD4B UPI0003C8C442 +33	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca nemestrina (Pig-tailed macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Papio anubis (Olive baboon) Colobus angolensis palliatus (Peters' Angolan colobus) Piliocolobus tephrosceles (Ugandan red Colobus) And more	304	UniRef90_P10646	Cluster: Tissue factor pathway inhibitor	44

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
C9JQ14	P10646 C9JP39 A0A2J8PRV7 A0A2J8PRT0 C9JT76 A0A2J8PRT7 C9J103 A0A2J8PRW3 UPI000002CD4B UPI0003C8C442 +80	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Piliocolobus tephrosceles (Ugandan red Colobus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) And more	304	UniRef50_P10646	Cluster: Tissue factor pathway inhibitor	91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC007319 Genomic DNA. No translation available. AC098485 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC007319 Genomic DNA. No translation available.
AC098485 Genomic DNA. No translation available.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000421427; ENSP00000408170; ENSG00000003436. ENST00000437725; ENSP00000388159; ENSG00000003436.
UCSC genome browser More...UCSCⁱ	uc061qmw.1. human.

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000003436.14.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11760. TFPI.
Open Targets More...OpenTargetsⁱ	ENSG00000003436.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4295. Eukaryota. ENOG410XQNP. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114929.
HOGENOMⁱ	HOG000231818.

Miscellaneous databases

ChiTaRSⁱ	TFPI. human.

ChiTaRSⁱ

TFPI. human.

Gene expression databases

Bgeeⁱ	ENSG00000003436.

Bgeeⁱ

ENSG00000003436.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109. KU. 1 hit.
Gene3Dⁱ	4.10.410.10. 1 hit.
InterProⁱ	View protein in InterPro IPR002223. Kunitz_BPTI. IPR036880. Kunitz_BPTI_sf. IPR020901. Prtase_inh_Kunz-CS. IPR029864. TFPI1.
PANTHERⁱ	PTHR10083:SF317. PTHR10083:SF317. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00014. Kunitz_BPTI. 1 hit.
PRINTSⁱ	PR00759. BASICPTASE.
SMARTⁱ	View protein in SMART SM00131. KU. 1 hit.
SUPFAMⁱ	SSF57362. SSF57362. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00280. BPTI_KUNITZ_1. 1 hit. PS50279. BPTI_KUNITZ_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C9JQ14_HUMAN
Accessionⁱ	C9JQ14Primary (citable) accession number: C9JQ14
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 3, 2009
	Last sequence update:	November 3, 2009
	Last modified:	March 28, 2018
	This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - C9JQ14 (C9JQ14_HUMAN)

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Tissue factor pathway inhibitor

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Molecule processing

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C9JQ14 (C9JQ14_HUMAN)

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Tissue factor pathway inhibitor

TFPI

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ