ID   C9JPM9_HUMAN            Unreviewed;       183 AA.
AC   C9JPM9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=Leucine-rich repeat transmembrane neuronal protein 1 {ECO:0000256|ARBA:ARBA00044114};
DE   Flags: Fragment;
GN   Name=LRRTM1 {ECO:0000313|Ensembl:ENSP00000389473.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389473.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000389473.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000389473.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Exhibits strong synaptogenic activity, restricted to
CC       excitatory presynaptic differentiation, acting at both pre- and
CC       postsynaptic level. {ECO:0000256|ARBA:ARBA00043936}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC       Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00035006}; Single-pass
CC       type I membrane protein {ECO:0000256|ARBA:ARBA00035006}.
CC   -!- SIMILARITY: Belongs to the LRRTM family.
CC       {ECO:0000256|ARBA:ARBA00038250}.
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DR   EMBL; AC016670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JPM9; -.
DR   SMR; C9JPM9; -.
DR   MassIVE; C9JPM9; -.
DR   PeptideAtlas; C9JPM9; -.
DR   ProteomicsDB; 11135; -.
DR   Antibodypedia; 47487; 280 antibodies from 28 providers.
DR   Ensembl; ENST00000452811.1; ENSP00000389473.1; ENSG00000162951.11.
DR   UCSC; uc061lcx.1; human.
DR   HGNC; HGNC:19408; LRRTM1.
DR   VEuPathDB; HostDB:ENSG00000162951; -.
DR   GeneTree; ENSGT00940000161705; -.
DR   HOGENOM; CLU_000288_18_10_1; -.
DR   OMA; FHLCEDA; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000162951; Expressed in lateral nuclear group of thalamus and 108 other cell types or tissues.
DR   ExpressionAtlas; C9JPM9; baseline and differential.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24373:SF290; LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 1; 1.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Proteomics identification {ECO:0007829|MaxQB:C9JPM9,
KW   ECO:0007829|PeptideAtlas:C9JPM9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..183
FT                   /note="Leucine-rich repeat transmembrane neuronal protein
FT                   1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002997423"
FT   NON_TER         183
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000389473.1"
SQ   SEQUENCE   183 AA;  20674 MW;  8B94E17EFAA23538 CRC64;
     MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA
     PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
     SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
     FQD
//