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C9JNR5

- C9JNR5_HUMAN

UniProt

C9JNR5 - C9JNR5_HUMAN

Protein
Submitted name:

Insulin B chain

Gene

INS

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Insulin B chainImported
    Gene namesi
    Name:INSImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6081. INS.

    Subcellular locationi

    Secreted SAAS annotation

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    Keywords - Cellular componenti

    SecretedSAAS annotation

    Pathology & Biotechi

    Protein family/group databases

    Allergomei2121. Hom s Insulin.

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiC9JNR5.
    BgeeiC9JNR5.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC9JNR5.
    SMRiC9JNR5. Positions 25-54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    OMAiLLHRERW.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    C9JNR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY   50
    TPKTRREAED LQAGELLQLD AARRQPHTRR LLHRERWNKA LE 92
    Length:92
    Mass (Da):10,631
    Last modified:November 3, 2009 - v1
    Checksum:i4E099F7685F10D39
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei92 – 921Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132217 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000421783; ENSP00000408400; ENSG00000254647.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC132217 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali C9JNR5.
    SMRi C9JNR5. Positions 25-54.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2121. Hom s Insulin.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000421783 ; ENSP00000408400 ; ENSG00000254647 .

    Organism-specific databases

    HGNCi HGNC:6081. INS.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi LLHRERW.

    Miscellaneous databases

    NextBioi 35487199.

    Gene expression databases

    ArrayExpressi C9JNR5.
    Bgeei C9JNR5.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiC9JNR5_HUMAN
    AccessioniPrimary (citable) accession number: C9JNR5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3