ID   C9JMS1_HUMAN            Unreviewed;        99 AA.
AC   C9JMS1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSP00000395068.1};
DE   Flags: Fragment;
GN   Name=AFF3 {ECO:0000313|Ensembl:ENSP00000395068.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395068.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000395068.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000395068.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC010736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC133108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JMS1; -.
DR   SMR; C9JMS1; -.
DR   MassIVE; C9JMS1; -.
DR   PeptideAtlas; C9JMS1; -.
DR   ProteomicsDB; 10885; -.
DR   Antibodypedia; 32831; 66 antibodies from 17 providers.
DR   Ensembl; ENST00000416492.5; ENSP00000395068.1; ENSG00000144218.21.
DR   UCSC; uc061mhv.1; human.
DR   HGNC; HGNC:6473; AFF3.
DR   VEuPathDB; HostDB:ENSG00000144218; -.
DR   GeneTree; ENSGT00950000182974; -.
DR   ChiTaRS; AFF3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144218; Expressed in cortical plate and 172 other cell types or tissues.
DR   ExpressionAtlas; C9JMS1; baseline and differential.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   Gene3D; 6.10.250.2670; -; 1.
DR   InterPro; IPR007797; AF4/FMR2.
DR   PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR   Pfam; PF05110; AF-4; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:C9JMS1,
KW   ECO:0007829|ProteomicsDB:C9JMS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          25..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         99
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000395068.1"
SQ   SEQUENCE   99 AA;  11594 MW;  428D1E429BE30411 CRC64;
     MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY SLFSEPYKTN
     KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPG
//