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C9JLW8

- F195B_HUMAN

UniProt

C9JLW8 - F195B_HUMAN

Protein

Protein FAM195B

Gene

FAM195B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM195B
    Gene namesi
    Name:FAM195B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28007. FAM195B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165431912.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9797Protein FAM195BPRO_0000393954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Phosphoserine2 Publications
    Modified residuei24 – 241Phosphoserine1 Publication
    Modified residuei41 – 411PhosphotyrosineBy similarity
    Modified residuei79 – 791N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiC9JLW8.
    PaxDbiC9JLW8.
    PRIDEiC9JLW8.

    PTM databases

    PhosphoSiteiC9JLW8.

    Expressioni

    Gene expression databases

    BgeeiC9JLW8.

    Organism-specific databases

    HPAiHPA045542.

    Interactioni

    Protein-protein interaction databases

    BioGridi131518. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliC9JLW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM195 family.Curated

    Phylogenomic databases

    eggNOGiNOG41066.
    HOGENOMiHOG000035119.
    OrthoDBiEOG7RRF8X.
    PhylomeDBiC9JLW8.
    TreeFamiTF326620.

    Family and domain databases

    InterProiIPR029428. FAM195.
    [Graphical view]
    PfamiPF14799. FAM195. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9JLW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSPVSRVV YNGKRTSSPR SPPSSSEIFT PAHEENVRFI YEAWQGVERD   50
    LRGQVPGGER GLVEEYVEKV PNPSLKTFKP IDLSDLKRRS TQDAKKS 97
    Length:97
    Mass (Da):10,920
    Last modified:November 3, 2009 - v1
    Checksum:iD92176E755159A81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125584 mRNA. Translation: BAC86211.1. Sequence problems.
    AC174470 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89687.1.
    CCDSiCCDS45814.1.
    RefSeqiNP_001087236.1. NM_001093767.2.
    NP_997251.2. NM_207368.4.
    UniGeneiHs.514632.

    Genome annotation databases

    EnsembliENST00000455127; ENSP00000409009; ENSG00000225663.
    ENST00000457257; ENSP00000408827; ENSG00000225663.
    ENST00000538396; ENSP00000445543; ENSG00000225663.
    ENST00000574190; ENSP00000458720; ENSG00000225663.
    ENST00000576730; ENSP00000458707; ENSG00000225663.
    GeneIDi348262.
    KEGGihsa:348262.
    UCSCiuc010wuy.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK125584 mRNA. Translation: BAC86211.1 . Sequence problems.
    AC174470 Genomic DNA. No translation available.
    CH471099 Genomic DNA. Translation: EAW89687.1 .
    CCDSi CCDS45814.1.
    RefSeqi NP_001087236.1. NM_001093767.2.
    NP_997251.2. NM_207368.4.
    UniGenei Hs.514632.

    3D structure databases

    ProteinModelPortali C9JLW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131518. 3 interactions.

    PTM databases

    PhosphoSitei C9JLW8.

    Proteomic databases

    MaxQBi C9JLW8.
    PaxDbi C9JLW8.
    PRIDEi C9JLW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000455127 ; ENSP00000409009 ; ENSG00000225663 .
    ENST00000457257 ; ENSP00000408827 ; ENSG00000225663 .
    ENST00000538396 ; ENSP00000445543 ; ENSG00000225663 .
    ENST00000574190 ; ENSP00000458720 ; ENSG00000225663 .
    ENST00000576730 ; ENSP00000458707 ; ENSG00000225663 .
    GeneIDi 348262.
    KEGGi hsa:348262.
    UCSCi uc010wuy.1. human.

    Organism-specific databases

    CTDi 348262.
    GeneCardsi GC17M079783.
    H-InvDB HIX0014255.
    HGNCi HGNC:28007. FAM195B.
    HPAi HPA045542.
    neXtProti NX_C9JLW8.
    PharmGKBi PA165431912.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41066.
    HOGENOMi HOG000035119.
    OrthoDBi EOG7RRF8X.
    PhylomeDBi C9JLW8.
    TreeFami TF326620.

    Miscellaneous databases

    GenomeRNAii 348262.
    NextBioi 99380.
    PROi C9JLW8.

    Gene expression databases

    Bgeei C9JLW8.

    Family and domain databases

    InterProi IPR029428. FAM195.
    [Graphical view ]
    Pfami PF14799. FAM195. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-24, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF195B_HUMAN
    AccessioniPrimary (citable) accession number: C9JLW8
    Secondary accession number(s): Q6ZUL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3