Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mapk-regulated corepressor-interacting protein 1

Gene

FAM195B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The phosphorylation status of FAM195B functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated FAM195B binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, FAM195B releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).1 Publication

GO - Biological processi

  • regulation of epithelial to mesenchymal transition Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mapk-regulated corepressor-interacting protein 11 Publication
Alternative name(s):
Protein FAM195B
Gene namesi
Name:FAM195B
Synonyms:MCRIP11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28007. FAM195B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165431912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Mapk-regulated corepressor-interacting protein 1PRO_0000393954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineCombined sources1 Publication
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei30 – 301Phosphothreonine1 Publication
Modified residuei41 – 411PhosphotyrosineBy similarity
Modified residuei79 – 791N6-acetyllysineCombined sources

Post-translational modificationi

Phosphorylation by MAPK3/1 (ERK1/2) regulates FAM195B binding to CTBP(s) (PubMed:25728771).1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiC9JLW8.
MaxQBiC9JLW8.
PaxDbiC9JLW8.
PRIDEiC9JLW8.
TopDownProteomicsiC9JLW8.

PTM databases

iPTMnetiC9JLW8.
PhosphoSiteiC9JLW8.

Expressioni

Gene expression databases

BgeeiENSG00000225663.
ExpressionAtlasiC9JLW8. baseline and differential.
GenevisibleiC9JLW8. HS.

Organism-specific databases

HPAiHPA045542.

Interactioni

Subunit structurei

Interacts (unphosphorylated form, via the PXDLS motif) with CTBP1, competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771). Interacts with CTBP2 (PubMed:25728771).1 Publication

Protein-protein interaction databases

BioGridi131518. 1 interaction.
IntActiC9JLW8. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliC9JLW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi80 – 845PXDLS motifCurated

Sequence similaritiesi

Belongs to the FAM195 family.Curated

Phylogenomic databases

eggNOGiENOG410IYRZ. Eukaryota.
ENOG411247K. LUCA.
GeneTreeiENSGT00530000064168.
HOGENOMiHOG000035119.
InParanoidiC9JLW8.
PhylomeDBiC9JLW8.
TreeFamiTF326620.

Family and domain databases

InterProiIPR029428. FAM195.
[Graphical view]
PfamiPF14799. FAM195. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JLW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSPVSRVV YNGKRTSSPR SPPSSSEIFT PAHEENVRFI YEAWQGVERD
60 70 80 90
LRGQVPGGER GLVEEYVEKV PNPSLKTFKP IDLSDLKRRS TQDAKKS
Length:97
Mass (Da):10,920
Last modified:November 3, 2009 - v1
Checksum:iD92176E755159A81
GO

Sequence cautioni

The sequence BAC86211 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125584 mRNA. Translation: BAC86211.1. Sequence problems.
AC174470 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89687.1.
CCDSiCCDS45814.1.
RefSeqiNP_001087236.1. NM_001093767.2.
NP_997251.2. NM_207368.4.
UniGeneiHs.514632.

Genome annotation databases

EnsembliENST00000455127; ENSP00000409009; ENSG00000225663.
ENST00000538396; ENSP00000445543; ENSG00000225663.
ENST00000574190; ENSP00000458720; ENSG00000225663.
ENST00000576730; ENSP00000458707; ENSG00000225663.
GeneIDi348262.
KEGGihsa:348262.
UCSCiuc010wuy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125584 mRNA. Translation: BAC86211.1. Sequence problems.
AC174470 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89687.1.
CCDSiCCDS45814.1.
RefSeqiNP_001087236.1. NM_001093767.2.
NP_997251.2. NM_207368.4.
UniGeneiHs.514632.

3D structure databases

ProteinModelPortaliC9JLW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131518. 1 interaction.
IntActiC9JLW8. 2 interactions.

PTM databases

iPTMnetiC9JLW8.
PhosphoSiteiC9JLW8.

Proteomic databases

EPDiC9JLW8.
MaxQBiC9JLW8.
PaxDbiC9JLW8.
PRIDEiC9JLW8.
TopDownProteomicsiC9JLW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455127; ENSP00000409009; ENSG00000225663.
ENST00000538396; ENSP00000445543; ENSG00000225663.
ENST00000574190; ENSP00000458720; ENSG00000225663.
ENST00000576730; ENSP00000458707; ENSG00000225663.
GeneIDi348262.
KEGGihsa:348262.
UCSCiuc010wuy.3. human.

Organism-specific databases

CTDi348262.
GeneCardsiFAM195B.
H-InvDBHIX0014255.
HGNCiHGNC:28007. FAM195B.
HPAiHPA045542.
MIMi616514. gene.
neXtProtiNX_C9JLW8.
PharmGKBiPA165431912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYRZ. Eukaryota.
ENOG411247K. LUCA.
GeneTreeiENSGT00530000064168.
HOGENOMiHOG000035119.
InParanoidiC9JLW8.
PhylomeDBiC9JLW8.
TreeFamiTF326620.

Miscellaneous databases

GenomeRNAii348262.
PROiC9JLW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000225663.
ExpressionAtlasiC9JLW8. baseline and differential.
GenevisibleiC9JLW8. HS.

Family and domain databases

InterProiIPR029428. FAM195.
[Graphical view]
PfamiPF14799. FAM195. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF195B_HUMAN
AccessioniPrimary (citable) accession number: C9JLW8
Secondary accession number(s): Q6ZUL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: November 3, 2009
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.