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Protein

Mapk-regulated corepressor-interacting protein 1

Gene

MCRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition (PubMed:25728771).1 Publication

GO - Biological processi

  • regulation of epithelial to mesenchymal transition Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Mapk-regulated corepressor-interacting protein 11 Publication
Alternative name(s):
Granulin-21 Publication
Protein FAM195B
Gene namesi
Name:MCRIP11 PublicationImported
Synonyms:FAM195B, GRAN21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000225663.7
HGNCiHGNC:28007 MCRIP1
MIMi616514 gene
neXtProtiNX_C9JLW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000225663
PharmGKBiPA165431912

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939541 – 97Mapk-regulated corepressor-interacting protein 1Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1 Publication1
Modified residuei24PhosphoserineCombined sources1
Modified residuei30Phosphothreonine1 Publication1
Modified residuei41PhosphotyrosineBy similarity1
Modified residuei79N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s) (PubMed:25728771).1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiC9JLW8
MaxQBiC9JLW8
PaxDbiC9JLW8
PRIDEiC9JLW8
TopDownProteomicsiC9JLW8

PTM databases

iPTMnetiC9JLW8
PhosphoSitePlusiC9JLW8

Expressioni

Gene expression databases

BgeeiENSG00000225663
ExpressionAtlasiC9JLW8 baseline and differential
GenevisibleiC9JLW8 HS

Organism-specific databases

HPAiHPA045542

Interactioni

Subunit structurei

Interacts (unphosphorylated form, via the PXDLS motif) with CTBP1, competitively inhibiting CTBP-ZEB1 interaction (PubMed:25728771). Interacts with CTBP2 (PubMed:25728771). Interacts with MCRIP2 (PubMed:26184334). Interacts with DDX6 (PubMed:26184334).2 Publications

Protein-protein interaction databases

BioGridi131518, 1 interactor
IntActiC9JLW8, 5 interactors
MINTiC9JLW8

Structurei

3D structure databases

ProteinModelPortaliC9JLW8
SMRiC9JLW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi80 – 84PXDLS motifCurated5

Sequence similaritiesi

Belongs to the MCRIP family.Curated

Phylogenomic databases

eggNOGiENOG410IYRZ Eukaryota
ENOG411247K LUCA
GeneTreeiENSGT00530000064168
HOGENOMiHOG000035119
InParanoidiC9JLW8
PhylomeDBiC9JLW8
TreeFamiTF326620

Family and domain databases

InterProiView protein in InterPro
IPR029428 MCRIP
PfamiView protein in Pfam
PF14799 FAM195, 1 hit

Sequencei

Sequence statusi: Complete.

C9JLW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSPVSRVV YNGKRTSSPR SPPSSSEIFT PAHEENVRFI YEAWQGVERD
60 70 80 90
LRGQVPGGER GLVEEYVEKV PNPSLKTFKP IDLSDLKRRS TQDAKKS
Length:97
Mass (Da):10,920
Last modified:November 3, 2009 - v1
Checksum:iD92176E755159A81
GO

Sequence cautioni

The sequence BAC86211 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125584 mRNA Translation: BAC86211.1 Sequence problems.
AC174470 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89687.1
CCDSiCCDS45814.1
RefSeqiNP_001087236.1, NM_001093767.2
NP_997251.2, NM_207368.4
UniGeneiHs.514632

Genome annotation databases

EnsembliENST00000455127; ENSP00000409009; ENSG00000225663
ENST00000538396; ENSP00000445543; ENSG00000225663
ENST00000574190; ENSP00000458720; ENSG00000225663
ENST00000576730; ENSP00000458707; ENSG00000225663
GeneIDi348262
KEGGihsa:348262
UCSCiuc010wuy.3 human

Similar proteinsi

Entry informationi

Entry nameiMCRI1_HUMAN
AccessioniPrimary (citable) accession number: C9JLW8
Secondary accession number(s): Q6ZUL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: November 3, 2009
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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