ID   CK095_HUMAN             Reviewed;         678 AA.
AC   C9JLR9; A6NLS7; Q3C1V4;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   27-MAY-2015, entry version 41.
DE   RecName: Full=Uncharacterized protein C11orf95;
GN   Name=C11orf95;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 162-538.
RA   Totoki Y., Yada T., Sakaki Y., Takeda T.;
RT   "Identification of novel human genes predicted by combining multiple
RT   gene-finders.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   CHROMOSOMAL TRANSLOCATION WITH MKL2.
RX   PubMed=20607705; DOI=10.1002/gcc.20788;
RA   Huang D., Sumegi J., Dal Cin P., Reith J.D., Yasuda T., Nelson M.,
RA   Muirhead D., Bridge J.A.;
RT   "C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13)
RT   in chondroid lipoma.";
RL   Genes Chromosomes Cancer 49:810-818(2010).
RN   [4]
RP   CHROMOSOMAL TRANSLOCATION WITH RELA.
RX   PubMed=24553141; DOI=10.1038/nature13109;
RA   Parker M., Mohankumar K.M., Punchihewa C., Weinlich R., Dalton J.D.,
RA   Li Y., Lee R., Tatevossian R.G., Phoenix T.N., Thiruvenkatam R.,
RA   White E., Tang B., Orisme W., Gupta K., Rusch M., Chen X., Li Y.,
RA   Nagahawhatte P., Hedlund E., Finkelstein D., Wu G., Shurtleff S.,
RA   Easton J., Boggs K., Yergeau D., Vadodaria B., Mulder H.L.,
RA   Becksfort J., Becksford J., Gupta P., Huether R., Ma J., Song G.,
RA   Gajjar A., Merchant T., Boop F., Smith A.A., Ding L., Lu C., Ochoa K.,
RA   Zhao D., Fulton R.S., Fulton L.L., Mardis E.R., Wilson R.K.,
RA   Downing J.R., Green D.R., Zhang J., Ellison D.W., Gilbertson R.J.;
RT   "C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in
RT   ependymoma.";
RL   Nature 506:451-455(2014).
CC   -!- DISEASE: Note=A chromosomal aberration involving MKL2 is found in
CC       3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MKL2
CC       produces a C11orf95-MKL2 fusion protein (PubMed:20607705).
CC       {ECO:0000269|PubMed:20607705}.
CC   -!- DISEASE: Note=A chromosomal aberration involving RELA is found in
CC       more than two-thirds of supratentorial ependymomas. Translocation
CC       with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA
CC       translocations are potent oncogenes that probably transform neural
CC       stem cells by driving an aberrant NF-kappa-B transcription program
CC       (PubMed:24553141). {ECO:0000269|PubMed:24553141}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR   EMBL; AP006289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB231751; BAE46893.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001138408.1; NM_001144936.1.
DR   UniGene; Hs.191073; -.
DR   ProteinModelPortal; C9JLR9; -.
DR   STRING; 9606.ENSP00000413719; -.
DR   PhosphoSite; C9JLR9; -.
DR   BioMuta; C11orf95; -.
DR   MaxQB; C9JLR9; -.
DR   PaxDb; C9JLR9; -.
DR   PRIDE; C9JLR9; -.
DR   Ensembl; ENST00000433688; ENSP00000482180; ENSG00000188070.
DR   GeneID; 65998; -.
DR   KEGG; hsa:65998; -.
DR   UCSC; uc010rmv.2; human.
DR   CTD; 65998; -.
DR   GeneCards; GC11M063527; -.
DR   HGNC; HGNC:28449; C11orf95.
DR   MIM; 615699; gene.
DR   neXtProt; NX_C9JLR9; -.
DR   Orphanet; 251636; Ependymoma.
DR   PharmGKB; PA165543266; -.
DR   eggNOG; NOG74949; -.
DR   GeneTree; ENSGT00600000084617; -.
DR   HOGENOM; HOG000143422; -.
DR   InParanoid; C9JLR9; -.
DR   PhylomeDB; C9JLR9; -.
DR   GenomeRNAi; 65998; -.
DR   NextBio; 67496; -.
DR   PRO; PR:C9JLR9; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; C9JLR9; baseline and differential.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   SMART; SM00355; ZnF_C2H2; 4.
PE   2: Evidence at transcript level;
KW   Chromosomal rearrangement; Complete proteome; Reference proteome.
FT   CHAIN         1    678       Uncharacterized protein C11orf95.
FT                                /FTId=PRO_0000393909.
FT   COMPBIAS    178    200       Glu-rich.
FT   COMPBIAS    222    259       Arg-rich.
FT   COMPBIAS    389    400       Poly-Glu.
FT   COMPBIAS    492    572       Pro-rich.
FT   COMPBIAS    512    554       Glu-rich.
FT   SITE        138    138       Breakpoint for translocation to form
FT                                C11orf95-MLK2 fusion protein.
SQ   SEQUENCE   678 AA;  73197 MW;  5F6968486885F093 CRC64;
     MEPGGDHRSR SSGGRGGPGP AVASARGRRL PPAGSSGSAE PEEDEGGQDL QLEGGALGSW
     GSAPLPSSRA RGPASSGRKY SDHCEARASR PGKSRIPGRD HRRYYHDHWR LEYLMDFNPA
     RHGMVCMVCG SSLATLKLST IKRHIRQKHP YSLHWSPREK EVISNSWDAH LGLGACGEAE
     GLGVQGAEEE EEEEEEEEEE GAGVPACPPK GPGKAPAGGG CRRQRRGGPV APRARRLRLS
     ASRRAGGSRG LGARRLERRL KESLQNWFRA ECLMDYDPRG NRLVCMACGR ALPSLHLDDI
     RAHVLEVHPG SLGLSGPQRS ALLQAWGGQP EALSELTQSP PGDDLAPQDL TGKSRDSASA
     AGAPSSQDLS PPDVKEEAGW VPERPGPAEE EEELEEGEGE RAGVPGRSPR GRAHRRHPQE
     RWRLEYLMEL DGGRRGLVCG VCGGALASLK MSTIERHIRR RHPGSTRLGG PVQALIAREW
     SEKAAHLLAL GPPRPESPQG PIPPGTAAAS DEGGGDEEEE PEEEEEEWGD VPLSPGAPLE
     RPAEEEEDEE DGQEPGGLAL PPPPPPPPPP PPRSREQRRN YQPRWRGEYL MDYDGSRRGL
     VCMVCGGALA TLKVSTIKRH ILQVHPFSMD FTPEERQTIL EAYEEAALRC YGHEGFGPPA
     PAPRDGGADL KSGAVCRA
//