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Protein

Uncharacterized protein C11orf95

Gene

C11orf95

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C11orf95
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28449. C11orf95.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MKL2 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MKL2 produces a C11orf95-MKL2 fusion protein (PubMed:20607705).

A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei138 – 1381Breakpoint for translocation to form C11orf95-MLK2 fusion protein

Organism-specific databases

MalaCardsiC11orf95.
Orphaneti251636. Ependymoma.
PharmGKBiPA165543266.

Polymorphism and mutation databases

BioMutaiC11orf95.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Uncharacterized protein C11orf95PRO_0000393909Add
BLAST

Proteomic databases

MaxQBiC9JLR9.
PRIDEiC9JLR9.

PTM databases

iPTMnetiC9JLR9.
PhosphoSiteiC9JLR9.

Expressioni

Gene expression databases

ExpressionAtlasiC9JLR9. baseline and differential.
GenevisibleiC9JLR9. HS.

Organism-specific databases

HPAiHPA045002.

Structurei

3D structure databases

ProteinModelPortaliC9JLR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi178 – 20023Glu-richAdd
BLAST
Compositional biasi222 – 25938Arg-richAdd
BLAST
Compositional biasi389 – 40012Poly-GluAdd
BLAST
Compositional biasi492 – 57281Pro-richAdd
BLAST
Compositional biasi512 – 55443Glu-richAdd
BLAST

Phylogenomic databases

GeneTreeiENSGT00600000084617.
HOGENOMiHOG000143422.
InParanoidiC9JLR9.
OMAiGGCRRQR.
OrthoDBiEOG091G02ZF.
PhylomeDBiC9JLR9.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JLR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGGDHRSR SSGGRGGPGP AVASARGRRL PPAGSSGSAE PEEDEGGQDL
60 70 80 90 100
QLEGGALGSW GSAPLPSSRA RGPASSGRKY SDHCEARASR PGKSRIPGRD
110 120 130 140 150
HRRYYHDHWR LEYLMDFNPA RHGMVCMVCG SSLATLKLST IKRHIRQKHP
160 170 180 190 200
YSLHWSPREK EVISNSWDAH LGLGACGEAE GLGVQGAEEE EEEEEEEEEE
210 220 230 240 250
GAGVPACPPK GPGKAPAGGG CRRQRRGGPV APRARRLRLS ASRRAGGSRG
260 270 280 290 300
LGARRLERRL KESLQNWFRA ECLMDYDPRG NRLVCMACGR ALPSLHLDDI
310 320 330 340 350
RAHVLEVHPG SLGLSGPQRS ALLQAWGGQP EALSELTQSP PGDDLAPQDL
360 370 380 390 400
TGKSRDSASA AGAPSSQDLS PPDVKEEAGW VPERPGPAEE EEELEEGEGE
410 420 430 440 450
RAGVPGRSPR GRAHRRHPQE RWRLEYLMEL DGGRRGLVCG VCGGALASLK
460 470 480 490 500
MSTIERHIRR RHPGSTRLGG PVQALIAREW SEKAAHLLAL GPPRPESPQG
510 520 530 540 550
PIPPGTAAAS DEGGGDEEEE PEEEEEEWGD VPLSPGAPLE RPAEEEEDEE
560 570 580 590 600
DGQEPGGLAL PPPPPPPPPP PPRSREQRRN YQPRWRGEYL MDYDGSRRGL
610 620 630 640 650
VCMVCGGALA TLKVSTIKRH ILQVHPFSMD FTPEERQTIL EAYEEAALRC
660 670
YGHEGFGPPA PAPRDGGADL KSGAVCRA
Length:678
Mass (Da):73,197
Last modified:November 3, 2009 - v1
Checksum:i5F6968486885F093
GO

Sequence cautioni

The sequence BAE46893 differs from that shown.Probable cloning artifact.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006289 Genomic DNA. No translation available.
AB231751 mRNA. Translation: BAE46893.1. Sequence problems.
RefSeqiNP_001138408.1. NM_001144936.1.
UniGeneiHs.191073.

Genome annotation databases

EnsembliENST00000433688; ENSP00000482180; ENSG00000188070.
GeneIDi65998.
KEGGihsa:65998.
UCSCiuc010rmv.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006289 Genomic DNA. No translation available.
AB231751 mRNA. Translation: BAE46893.1. Sequence problems.
RefSeqiNP_001138408.1. NM_001144936.1.
UniGeneiHs.191073.

3D structure databases

ProteinModelPortaliC9JLR9.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiC9JLR9.
PhosphoSiteiC9JLR9.

Polymorphism and mutation databases

BioMutaiC11orf95.

Proteomic databases

MaxQBiC9JLR9.
PRIDEiC9JLR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000433688; ENSP00000482180; ENSG00000188070.
GeneIDi65998.
KEGGihsa:65998.
UCSCiuc010rmv.3. human.

Organism-specific databases

CTDi65998.
GeneCardsiC11orf95.
HGNCiHGNC:28449. C11orf95.
HPAiHPA045002.
MalaCardsiC11orf95.
MIMi615699. gene.
neXtProtiNX_C9JLR9.
Orphaneti251636. Ependymoma.
PharmGKBiPA165543266.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00600000084617.
HOGENOMiHOG000143422.
InParanoidiC9JLR9.
OMAiGGCRRQR.
OrthoDBiEOG091G02ZF.
PhylomeDBiC9JLR9.

Miscellaneous databases

GenomeRNAii65998.
PROiC9JLR9.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiC9JLR9. baseline and differential.
GenevisibleiC9JLR9. HS.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCK095_HUMAN
AccessioniPrimary (citable) accession number: C9JLR9
Secondary accession number(s): A6NLS7, Q3C1V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: November 3, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.