C9JLE3 (C9JLE3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Secreted glypican-3 Ensembl ENSP00000377836

Gene names

Name:

GPC3 Ensembl ENSP00000377836

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000377836

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	603 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cell surface proteoglycan that bears heparan sulfate By similarity. RuleBase RU003519
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity RuleBase RU003519.
Sequence similarities	Belongs to the glypican family. RuleBase RU003518
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000377836

Ontologies

Keywords
Cellular component	Membrane
PTM	GPI-anchor RuleBase RU003519 Glycoprotein Heparan sulfate RuleBase RU003519 Lipoprotein Proteoglycan
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior axis specification Inferred from electronic annotation. Source: Compara body morphogenesis Inferred from electronic annotation. Source: Compara bone mineralization Inferred from electronic annotation. Source: Compara branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara cell proliferation involved in metanephros development Inferred from electronic annotation. Source: Compara coronary vasculature development Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara mesenchymal cell proliferation involved in ureteric bud development Inferred from electronic annotation. Source: Compara mesonephric duct morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of growth Inferred from electronic annotation. Source: Compara negative regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway Inferred from electronic annotation. Source: Compara positive regulation of endocytosis Inferred from electronic annotation. Source: Compara positive regulation of glucose import Inferred from electronic annotation. Source: Compara positive regulation of protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara
Cellular_component	anchored to plasma membrane Inferred from electronic annotation. Source: Compara lysosome Inferred from electronic annotation. Source: Compara proteinaceous extracellular matrix Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C9JLE3 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: 1930C0382E91AF60	FASTA	603	68,414
	10 20 30 40 50 60 MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK WVPETPVPGS 70 80 90 100 110 120 DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL KFLIIQNAAV FQEAFEIVVR 130 140 150 160 170 180 HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT DVSLYILGSD INVDDMVNEL FDSLFPVIYT 190 200 210 220 230 240 QLMNPGLPDS ALDINECLRG ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI 250 260 270 280 290 300 NTTDHLKFSK DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 310 320 330 340 350 360 LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTETEKKI WHFKYPIFFL 370 380 390 400 410 420 CIGLDLQIGK LCAHSQQRQY RSAYYPEDLF IDKKVLKVAH VEHEETLSSR RRELIQKLKS 430 440 450 460 470 480 FISFYSALPG YICSHSPVAE NDTLCWNGQE LVERYSQKAA RNGMKNQFNL HELKMKGPEP 490 500 510 520 530 540 VVSQIIDKLK HINQLLRTMS MPKGRVLDKN LDEEGFESGD CGDDEDECIG GSGDGMIKVK 550 560 570 580 590 600 NQLRFLAELA YDLDVDDAPG NSQQATPKDN EISTFHNLGN VHSPLKLLTS MAISVVCFFF LVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002420 Genomic DNA. No translation available. AF003529 Genomic DNA. No translation available. AL008712 Genomic DNA. No translation available. AL009174 Genomic DNA. No translation available. AL034401 Genomic DNA. No translation available. AL662851 Genomic DNA. No translation available. Z97196 Genomic DNA. No translation available. Z99570 Genomic DNA. No translation available.
IPI	IPI00719135.
RefSeq	NP_001158089.1. NM_001164617.1.
UniGene	Hs.644108.
3D structure databases
ProteinModelPortal	C9JLE3.
SMR	C9JLE3. Positions 34-498.
ModBase	Search...
Protein-protein interaction databases
STRING	C9JLE3.
Protocols and materials databases
DNASU	2719.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394299; ENSP00000377836; ENSG00000147257.
GeneID	2719.
KEGG	hsa:2719.
UCSC	uc010nrn.2. human.
Organism-specific databases
CTD	2719.
HGNC	HGNC:4451. GPC3.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000049177.
KO	K08109.
OMA	ENDTLCW.
Gene expression databases
ArrayExpress	C9JLE3.
Bgee	C9JLE3.
Family and domain databases
InterPro	IPR001863. Glypican. IPR015501. Glypican-3. IPR019803. Glypican_CS. [Graphical view]
PANTHER	PTHR10822. PTHR10822. 1 hit. PTHR10822:SF4. PTHR10822:SF4. 1 hit.
Pfam	PF01153. Glypican. 2 hits. [Graphical view]
PROSITE	PS01207. GLYPICAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GPC3. human.
GenomeRNAi	2719.
NextBio	10734.

Entry information

Entry name

C9JLE3_HUMAN

Accession

Primary (citable) accession number: C9JLE3

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 29 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.