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C9JKX7

- C9JKX7_HUMAN

UniProt

C9JKX7 - C9JKX7_HUMAN

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Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: Ensembl
  2. hydroxymethylglutaryl-CoA reductase activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. cholesterol biosynthetic process Source: Ensembl
  3. myoblast differentiation Source: Ensembl
  4. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  5. negative regulation of MAP kinase activity Source: Ensembl
  6. negative regulation of striated muscle cell apoptotic process Source: Ensembl
  7. negative regulation of vasodilation Source: Ensembl
  8. negative regulation of wound healing Source: Ensembl
  9. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
  10. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  11. positive regulation of skeletal muscle tissue development Source: Ensembl
  12. positive regulation of smooth muscle cell proliferation Source: Ensembl
  13. positive regulation of stress-activated MAPK cascade Source: Ensembl
  14. response to ethanol Source: Ensembl
  15. response to nutrient Source: Ensembl
  16. ubiquinone metabolic process Source: Ensembl
  17. visual learning Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
Gene namesi
Name:HMGCRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5006. HMGCR.

Subcellular locationi

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiC9JKX7.
ExpressionAtlasiC9JKX7. baseline and differential.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000119321.

Sequencei

Sequence statusi: Fragment.

C9JKX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10 
MLSRLFRMHG LFVASHPW
Length:18
Mass (Da):2,186
Last modified:July 13, 2010 - v2
Checksum:i9123A7BB7142F21B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei18 – 181Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000442032; ENSP00000409100; ENSG00000113161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008897 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000442032 ; ENSP00000409100 ; ENSG00000113161 .

Organism-specific databases

HGNCi HGNC:5006. HMGCR.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119321.

Miscellaneous databases

ChiTaRSi HMGCR. human.
NextBioi 35486873.

Gene expression databases

Bgeei C9JKX7.
ExpressionAtlasi C9JKX7. baseline and differential.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JKX7_HUMAN
AccessioniPrimary (citable) accession number: C9JKX7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: July 13, 2010
Last modified: November 26, 2014
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3