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C9JKX7

- C9JKX7_HUMAN

UniProt

C9JKX7 - C9JKX7_HUMAN

Protein
Submitted name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

HMGCR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA reductase (NADPH) activity Source: Ensembl
    2. hydroxymethylglutaryl-CoA reductase activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. cholesterol biosynthetic process Source: Ensembl
    3. embryo development Source: Ensembl
    4. isoprenoid biosynthetic process Source: Ensembl
    5. myoblast differentiation Source: Ensembl
    6. negative regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
    7. negative regulation of MAP kinase activity Source: Ensembl
    8. negative regulation of striated muscle cell apoptotic process Source: Ensembl
    9. negative regulation of vasodilation Source: Ensembl
    10. negative regulation of wound healing Source: Ensembl
    11. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
    12. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    13. positive regulation of skeletal muscle tissue development Source: Ensembl
    14. positive regulation of smooth muscle cell proliferation Source: Ensembl
    15. positive regulation of stress-activated MAPK cascade Source: Ensembl
    16. response to ethanol Source: Ensembl
    17. response to nutrient Source: Ensembl
    18. ubiquinone metabolic process Source: Ensembl
    19. visual learning Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductaseImported
    Gene namesi
    Name:HMGCRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5006. HMGCR.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular membrane-bounded organelle Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiC9JKX7.
    BgeeiC9JKX7.

    Sequencei

    Sequence statusi: Fragment.

    C9JKX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSRLFRMHG LFVASHPW                                      18
    Length:18
    Mass (Da):2,186
    Last modified:July 13, 2010 - v2
    Checksum:i9123A7BB7142F21B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei18 – 181Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008897 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000442032; ENSP00000409100; ENSG00000113161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008897 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000442032 ; ENSP00000409100 ; ENSG00000113161 .

    Organism-specific databases

    HGNCi HGNC:5006. HMGCR.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi Hmgcr. human.
    NextBioi 35486873.

    Gene expression databases

    ArrayExpressi C9JKX7.
    Bgeei C9JKX7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiC9JKX7_HUMAN
    AccessioniPrimary (citable) accession number: C9JKX7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3