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Protein
Submitted name:

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei64 – 65Reactive bondUniRule annotation2
Sitei122 – 123Reactive bondUniRule annotation2
Sitei214 – 215Reactive bondUniRule annotation2

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Tissue factor pathway inhibitorImported
Gene namesi
Name:TFPIImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000003436.14.
HGNCiHGNC:11760. TFPI.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000003436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500299656729 – 215Sequence analysisAdd BLAST187

Proteomic databases

MaxQBiC9JKV3.
PeptideAtlasiC9JKV3.

Expressioni

Gene expression databases

BgeeiENSG00000003436.
ExpressionAtlasiC9JKV3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JKV3.
SMRiC9JKV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 104BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini112 – 162BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.

Family and domain databases

CDDicd00109. KU. 2 hits.
Gene3Di4.10.410.10. 2 hits.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
IPR008296. TFPI-like.
IPR029864. TFPI1.
PANTHERiPTHR10083:SF317. PTHR10083:SF317. 1 hit.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 2 hits.
PIRSFiPIRSF001620. TFPI. 1 hit.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 2 hits.
SUPFAMiSSF57362. SSF57362. 2 hits.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

C9JKV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYTMKKVHA LWASVCLLLN LAPAPLNADS EEDEEHTIIT DTELPPLKLM
60 70 80 90 100
HSFCAFKADD GPCKAIMKRF FFNIFTRQCE EFIYGGCEGN QNRFESLEEC
110 120 130 140 150
KKMCTREKPD FCFLEEDPGI CRGYITRYFY NNQTKQCERF KYGGCLGNMN
160 170 180 190 200
NFETLEECKN ICEDGPNGFQ VDNYGTQLNA VNNSLTPQST KVPSLFEFHG
210
PSWCLTPADR GLCRA
Length:215
Mass (Da):24,606
Last modified:November 3, 2009 - v1
Checksum:iD338BFC7B9FB1580
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei215Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007319 Genomic DNA. No translation available.
AC098485 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000435414; ENSP00000409177; ENSG00000003436.
UCSCiuc061qmu.1. human.

Similar proteinsi

Entry informationi

Entry nameiC9JKV3_HUMAN
AccessioniPrimary (citable) accession number: C9JKV3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported