ID   C9JKQ2_HUMAN            Unreviewed;        65 AA.
AC   C9JKQ2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 {ECO:0000256|ARBA:ARBA00018680};
DE   AltName: Full=Complex I-B12 {ECO:0000256|ARBA:ARBA00030217};
DE   AltName: Full=NADH-ubiquinone oxidoreductase B12 subunit {ECO:0000256|ARBA:ARBA00032688};
DE   Flags: Fragment;
GN   Name=NDUFB3 {ECO:0000313|Ensembl:ENSP00000401834};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401834, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000401834, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000401834}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [4] {ECO:0007829|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003195}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC       {ECO:0000256|ARBA:ARBA00004298}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFB3 subunit family.
CC       {ECO:0000256|ARBA:ARBA00005667}.
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DR   EMBL; AC007272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JKQ2; -.
DR   SMR; C9JKQ2; -.
DR   MassIVE; C9JKQ2; -.
DR   MaxQB; C9JKQ2; -.
DR   PeptideAtlas; C9JKQ2; -.
DR   ProteomicsDB; 10606; -.
DR   Antibodypedia; 34135; 161 antibodies from 26 providers.
DR   Ensembl; ENST00000450023; ENSP00000401834; ENSG00000119013.
DR   UCSC; uc061rhu.1; human.
DR   HGNC; HGNC:7698; NDUFB3.
DR   OpenTargets; ENSG00000119013; -.
DR   VEuPathDB; HostDB:ENSG00000119013; -.
DR   HOGENOM; CLU_2855538_0_0_1; -.
DR   OMA; RYMGGFT; -.
DR   ChiTaRS; NDUFB3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000119013; Expressed in right atrium auricular region and 207 other cell types or tissues.
DR   ExpressionAtlas; C9JKQ2; baseline and differential.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   InterPro; IPR012576; NDUFB3.
DR   PANTHER; PTHR15082:SF2; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3; 1.
DR   PANTHER; PTHR15082; NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT; 1.
DR   Pfam; PF08122; NDUF_B12; 1.
PE   1: Evidence at protein level;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Proteomics identification {ECO:0007829|EPD:C9JKQ2,
KW   ECO:0007829|MaxQB:C9JKQ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   NON_TER         65
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000401834"
SQ   SEQUENCE   65 AA;  7586 MW;  B723F2A59BD09DA7 CRC64;
     MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS
     VSFSD
//