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Protein

Tubulin alpha chain

Gene

TUBA4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin alpha chainUniRule annotation
Gene namesi
Name:TUBA4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:12407. TUBA4A.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127824.

PTM / Processingi

Proteomic databases

MaxQBiC9JJQ8.
PaxDbiC9JJQ8.
PeptideAtlasiC9JJQ8.
PRIDEiC9JJQ8.

Expressioni

Gene expression databases

BgeeiENSG00000127824.
ExpressionAtlasiC9JJQ8. baseline and differential.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC9JJQ8.
SMRiC9JJQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 198TubulinInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00760000119060.
HOGENOMiHOG000165712.

Family and domain databases

Gene3Di3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002452. Alpha_tubulin.
IPR000217. Tubulin.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JJQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPILPGTRR VTSGASPQVP LPFWRECISV HVGQAGVQMG NACWELYCLE
60 70 80 90 100
HGIQPDGQMP SDKTIGGGDD SFTTFFCETG AGKHVPRAVF VDLEPTVIDE
110 120 130 140 150
IRNGPYRQLF HPEQLITGKE DAANNYARGH YTIGKEIIDP VLDRIRKLSD
160 170 180 190
QCTGLQGFLV FHSFGGGTGS GFTSLLMERL SVDYGKKSKL EFSIYPAP
Length:198
Mass (Da):21,678
Last modified:November 3, 2009 - v1
Checksum:iE311C05987F08A25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei198Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068946 Genomic DNA. No translation available.
AC114803 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000456818; ENSP00000416992; ENSG00000127824.
UCSCiuc061suz.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC9JJQ8_HUMAN
AccessioniPrimary (citable) accession number: C9JJQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported