true2013-02-062024-03-27106U17LA_HUMANGeneration and annotation of the DNA sequences of human chromosomes 2 and 4.Hillier L.W.Graves T.A.Fulton R.S.Fulton L.A.Pepin K.H.Minx P.Wagner-McPherson C.Layman D.Wylie K.Sekhon M.Becker M.C.Fewell G.A.Delehaunty K.D.Miner T.L.Nash W.E.Kremitzki C.Oddy L.Du H.Sun H.Bradshaw-Cordum H.Ali J.Carter J.Cordes M.Harris A.Isak A.van Brunt A.Nguyen C.Du F.Courtney L.Kalicki J.Ozersky P.Abbott S.Armstrong J.Belter E.A.Caruso L.Cedroni M.Cotton M.Davidson T.Desai A.Elliott G.Erb T.Fronick C.Gaige T.Haakenson W.Haglund K.Holmes A.Harkins R.Kim K.Kruchowski S.S.Strong C.M.Grewal N.Goyea E.Hou S.Levy A.Martinka S.Mead K.McLellan M.D.Meyer R.Randall-Maher J.Tomlinson C.Dauphin-Kohlberg S.Kozlowicz-Reilly A.Shah N.Swearengen-Shahid S.Snider J.Strong J.T.Thompson J.Yoakum M.Leonard S.Pearman C.Trani L.Radionenko M.Waligorski J.E.Wang C.Rock S.M.Tin-Wollam A.-M.Maupin R.Latreille P.Wendl M.C.Yang S.-P.Pohl C.Wallis J.W.Spieth J.Bieri T.A.Berkowicz N.Nelson J.O.Osborne J.Ding L.Meyer R.'Sabo A.Shotland Y.Sinha P.Wohldmann P.E.Cook L.L.Hickenbotham M.T.Eldred J.Williams D.Jones T.A.She X.Ciccarelli F.D.Izaurralde E.Taylor J.Schmutz J.Myers R.M.Cox D.R.Huang X.McPherson J.D.Mardis E.R.Clifton S.W.Warren W.C.Chinwalla A.T.Eddy S.R.Marra M.A.Ovcharenko I.Furey T.S.Miller W.Eichler E.E.Bork P.Suyama M.Torrents D.Waterston R.H.Wilson R.K.doi:10.1038/nature034662005Nature434724-731NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]113 antibodies from 1 providershumanUSP17L10Not detectedEukaryotaUb-specific processing proteases41 hits in 1029 CRISPR screensTdarkProteinExpressed in bloodPeptidase_C19ECysteine proteinasesPapain-like_cys_pep_sfPeptidase_C19_UCHUSP_CSUSP_domINACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 17-LIKE PROTEIN 4-RELATEDUBIQUITIN CARBOXYL-TERMINAL HYDROLASEUCHCysteine proteinasesUSP_1USP_2USP_3Ubiquitin carboxyl-terminal hydrolase 17-like protein 103.4.19.12USP17L10Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.Belongs to the peptidase C19 family. USP17 subfamily.The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes it impossible to specifically assign data to a particular gene of the family. Oligonucleotides designed in RNAi experiments are for instance not specific for a given UPS17-like gene.Ubiquitin carboxyl-terminal hydrolase 17-like protein 10598861530USP80375Disordered382410Disordered477Polar residues480509Nucleophile89Proton acceptor3342009-11-031598867d1724de8b6d561de77717a43dff1cd0MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKPPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYKPPLANYMLFREHSQTCHRHKGCMLCTMQAHITRALHIPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMRKACLPGHKQVDRHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTLHNSAKVLILVLKRFPDVTGNKIAKNVQYPECLDMQPYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYSSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGVEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRRVEGTVPPDVLVIHQSKYKCRMKNHHPEQQSSLLNLSSTTPTDQESMNTGTLASLRGRTRRSKGKNKHSKRALLVCQtruetruetruetruetrue