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C9JJH3

- U17LA_HUMAN

UniProt

C9JJH3 - U17LA_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 10

Gene

USP17L10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891NucleophilePROSITE-ProRule annotation
    Active sitei334 – 3341Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 17-like protein 10 (EC:3.4.19.12)
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:44438. USP17L10.

    Subcellular locationi

    Nucleus By similarity. Endoplasmic reticulum By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Ubiquitin carboxyl-terminal hydrolase 17-like protein 10PRO_0000421086Add
    BLAST

    PTM databases

    PhosphoSiteiC9JJH3.

    Structurei

    3D structure databases

    ProteinModelPortaliC9JJH3.
    SMRiC9JJH3. Positions 49-372.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini80 – 375296USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP17 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000144638.
    OMAiNTAITHR.
    OrthoDBiEOG73NG35.
    PhylomeDBiC9JJH3.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9JJH3-1 [UniParc]FASTAAdd to Basket

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    MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD    50
    LCDDLAPVAR QLAPREKPPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY 100
    KPPLANYMLF REHSQTCHRH KGCMLCTMQA HITRALHIPG HVIQPSQALA 150
    AGFHRGKQED AHEFLMFTVD AMRKACLPGH KQVDRHSKDT TLIHQIFGGY 200
    WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN 250
    AYHCGVCLQR APASKTLTLH NSAKVLILVL KRFPDVTGNK IAKNVQYPEC 300
    LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYSSYVK AQEGQWYKMD 350
    DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGVEDTD 400
    RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF 450
    NVRRVEGTVP PDVLVIHQSK YKCRMKNHHP EQQSSLLNLS STTPTDQESM 500
    NTGTLASLRG RTRRSKGKNK HSKRALLVCQ 530
    Length:530
    Mass (Da):59,886
    Last modified:November 3, 2009 - v1
    Checksum:i69B4CBA90C75F372
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108519 Genomic DNA. No translation available.
    CCDSiCCDS59454.1.
    RefSeqiNP_001243781.1. NM_001256852.1.
    UniGeneiHs.741130.

    Genome annotation databases

    EnsembliENST00000417945; ENSP00000403760; ENSG00000231396.
    GeneIDi100287144.
    KEGGihsa:100287144.
    UCSCiuc031sdg.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC108519 Genomic DNA. No translation available.
    CCDSi CCDS59454.1.
    RefSeqi NP_001243781.1. NM_001256852.1.
    UniGenei Hs.741130.

    3D structure databases

    ProteinModelPortali C9JJH3.
    SMRi C9JJH3. Positions 49-372.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei C9JJH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000417945 ; ENSP00000403760 ; ENSG00000231396 .
    GeneIDi 100287144.
    KEGGi hsa:100287144.
    UCSCi uc031sdg.1. human.

    Organism-specific databases

    CTDi 100287144.
    GeneCardsi GC04P009215.
    HGNCi HGNC:44438. USP17L10.
    neXtProti NX_C9JJH3.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000144638.
    OMAi NTAITHR.
    OrthoDBi EOG73NG35.
    PhylomeDBi C9JJH3.
    TreeFami TF315281.

    Miscellaneous databases

    GenomeRNAii 100287144.
    NextBioi 20776895.

    Family and domain databases

    InterProi IPR006861. HABP4_PAIRBP1-bd.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF04774. HABP4_PAI-RBP1. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiU17LA_HUMAN
    AccessioniPrimary (citable) accession number: C9JJH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2013
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes it impossible to specifically assign data to a particular gene of the family. Oligonucleotides designed in RNAi experiments are for instance not specific for a given UPS17-like gene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3