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Protein

BTB/POZ domain-containing protein 19

Gene

BTBD19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 19
Gene namesi
Name:BTBD19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000222009.8.
HGNCiHGNC:27145. BTBD19.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000222009.
PharmGKBiPA165750488.

Polymorphism and mutation databases

BioMutaiBTBD19.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003942391 – 291BTB/POZ domain-containing protein 19Add BLAST291

Proteomic databases

PaxDbiC9JJ37.
PRIDEiC9JJ37.

Expressioni

Gene expression databases

BgeeiENSG00000222009.
ExpressionAtlasiC9JJ37. baseline and differential.

Organism-specific databases

HPAiHPA042633.
HPA076404.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000395461.

Structurei

3D structure databases

ProteinModelPortaliC9JJ37.
SMRiC9JJ37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 98BTBPROSITE-ProRule annotationAdd BLAST70
Domaini134 – 234BACKAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi272 – 275Poly-Arg4

Phylogenomic databases

eggNOGiKOG4350. Eukaryota.
ENOG410Z7D9. LUCA.
GeneTreeiENSGT00550000074511.
HOGENOMiHOG000294137.
HOVERGENiHBG104218.
InParanoidiC9JJ37.
OMAiWKCHALR.
OrthoDBiEOG091G0NVO.
PhylomeDBiC9JJ37.
TreeFamiTF330633.

Family and domain databases

InterProiView protein in InterPro
IPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ_sf.
PfamiView protein in Pfam
PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
SMARTiView protein in SMART
SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: C9JJ37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPLGLVVHG KAEPFSAALR SLVNNPRYSD VCFVVGQERQ EVFAHRCLLA
60 70 80 90 100
CRCNFFQRLL GTEPGPGVPS PVVLSTVPTE AFLAVLEFLY TNSVKLYRHS
110 120 130 140 150
VLEVLTAAVE YGLEELRELC LQFVVKVLDV DLVCEALQVA VTFGLGQLQE
160 170 180 190 200
RCVAFIEAHS QEALRTRGFL ELSAAALLPL LRSDKLCVDE AELVRAARSW
210 220 230 240 250
ARVGAAVLER PVAEVAAPVV KELRLALLAP AELSALEEQN RQEPLIPVEQ
260 270 280 290
IVEAWKCHAL RRGDEARGAP CRRRRGTLPR EHHRFLDLSF K
Length:291
Mass (Da):32,365
Last modified:November 3, 2009 - v1
Checksum:i7105A23F9C2FCF62
GO
Isoform 2 (identifier: C9JJ37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-291: VAVTFGLGQL...HHRFLDLSFK → HFWRPRRADQEVRRSRPSWLTRWP

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,496
Checksum:iE5670B4AC412E590
GO

Sequence cautioni

The sequence CAX15036 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAX15037 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039226139 – 291VAVTF…DLSFK → HFWRPRRADQEVRRSRPSWL TRWP in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK304611 mRNA. Translation: BAG65396.1.
AL592166 Genomic DNA. Translation: CAX15036.1. Sequence problems.
AL592166 Genomic DNA. Translation: CAX15037.1. Sequence problems.
RefSeqiNP_001130009.1. NM_001136537.1. [C9JJ37-1]
UniGeneiHs.632400.

Genome annotation databases

EnsembliENST00000439563; ENSP00000410162; ENSG00000222009. [C9JJ37-2]
ENST00000450269; ENSP00000395461; ENSG00000222009. [C9JJ37-1]
GeneIDi149478.
KEGGihsa:149478.
UCSCiuc010ole.1. human. [C9JJ37-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBTBDJ_HUMAN
AccessioniPrimary (citable) accession number: C9JJ37
Secondary accession number(s): B4E384, B7ZC36, B7ZC37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: November 3, 2009
Last modified: November 22, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM