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C9JIZ6

- C9JIZ6_HUMAN

UniProt

C9JIZ6 - C9JIZ6_HUMAN

Protein
Submitted name:

Prosaposin

Gene

PSAP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. sphingolipid metabolic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ProsaposinImported
    Gene namesi
    Name:PSAPImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9498. PSAP.

    Subcellular locationi

    GO - Cellular componenti

    1. lysosome Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiC9JIZ6.

    Expressioni

    Gene expression databases

    ArrayExpressiC9JIZ6.
    BgeeiC9JIZ6.

    Structurei

    3D structure databases

    ProteinModelPortaliC9JIZ6.
    SMRiC9JIZ6. Positions 60-139, 195-274, 314-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000049216.
    OMAiCKNYINQ.

    Family and domain databases

    Gene3Di1.10.225.10. 4 hits.
    InterProiIPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR021165. Saposin_chordata.
    IPR008139. SaposinB.
    [Graphical view]
    PfamiPF02199. SapA. 2 hits.
    PF05184. SapB_1. 4 hits.
    PF03489. SapB_2. 4 hits.
    [Graphical view]
    PIRSFiPIRSF002431. Saposin. 1 hit.
    PRINTSiPR01797. SAPOSIN.
    SMARTiSM00162. SAPA. 2 hits.
    SM00741. SapB. 4 hits.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 4 hits.
    PROSITEiPS51110. SAP_A. 2 hits.
    PS50015. SAP_B. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9JIZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ    50
    TVWNKPTVKS LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP 100
    NMSASCKEIV DSYLPVILDI IKGEMSRPGE VCSALNLCES LQKHLAELNH 150
    QKQLESNKIP ELDMTEVVAP FMANIPLLLY PQDGPRSKPQ PKDNGDVCQD 200
    CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI CKNYISQYSE 250
    IAIQMMMHML QQPKEICALV GFCDEVKEMP MQTLVPAKVA SKNVIPALEL 300
    VEPIKKHEVP AKSDVYCEVC EFLVKEVTKL IDNNKTEKEI LDAFDKMCSK 350
    LPKSLSEECQ EVVDTYGSSI LSILLEEVSP ELVCSMLHLC SGTRLPALTV 400
    HVTQPKDGGF CEVCKKLVGY LDRNLEKNST KQEILAALEK GCSFLPDPYQ 450
    KQCDQFVAEY EPVLIEILVE VMDPSFVCLK IGACPSAHKP LLGTEKCIWG 500
    PSYWCQNTET AAQCNAVEHC KRHVWN 526
    Length:526
    Mass (Da):58,354
    Last modified:November 3, 2009 - v1
    Checksum:iF26E56CAC3A9DCE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073370 Genomic DNA. No translation available.
    AL731541 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000394934; ENSP00000378392; ENSG00000197746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073370 Genomic DNA. No translation available.
    AL731541 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali C9JIZ6.
    SMRi C9JIZ6. Positions 60-139, 195-274, 314-486.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi C9JIZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394934 ; ENSP00000378392 ; ENSG00000197746 .

    Organism-specific databases

    HGNCi HGNC:9498. PSAP.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000049216.
    OMAi CKNYINQ.

    Miscellaneous databases

    ChiTaRSi PSAP. human.
    NextBioi 35486688.

    Gene expression databases

    ArrayExpressi C9JIZ6.
    Bgeei C9JIZ6.

    Family and domain databases

    Gene3Di 1.10.225.10. 4 hits.
    InterProi IPR003119. SapA.
    IPR007856. SapB_1.
    IPR008138. SapB_2.
    IPR008373. Saposin.
    IPR011001. Saposin-like.
    IPR021165. Saposin_chordata.
    IPR008139. SaposinB.
    [Graphical view ]
    Pfami PF02199. SapA. 2 hits.
    PF05184. SapB_1. 4 hits.
    PF03489. SapB_2. 4 hits.
    [Graphical view ]
    PIRSFi PIRSF002431. Saposin. 1 hit.
    PRINTSi PR01797. SAPOSIN.
    SMARTi SM00162. SAPA. 2 hits.
    SM00741. SapB. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 4 hits.
    PROSITEi PS51110. SAP_A. 2 hits.
    PS50015. SAP_B. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiC9JIZ6_HUMAN
    AccessioniPrimary (citable) accession number: C9JIZ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3