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Protein
Submitted name:

Prosaposin

Gene

PSAP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
ProsaposinImported
Gene namesi
Name:PSAPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000197746.13
HGNCiHGNC:9498 PSAP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197746

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_500299774617 – 527Sequence analysisAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 138UniRule annotation
Disulfide bondi66 ↔ 132UniRule annotation
Disulfide bondi94 ↔ 106UniRule annotation
Disulfide bondi198 ↔ 274UniRule annotation
Disulfide bondi201 ↔ 268UniRule annotation
Disulfide bondi230 ↔ 241UniRule annotation
Disulfide bondi318 ↔ 391UniRule annotation
Disulfide bondi321 ↔ 385UniRule annotation
Disulfide bondi349 ↔ 360UniRule annotation
Disulfide bondi412 ↔ 485UniRule annotation
Disulfide bondi415 ↔ 479UniRule annotation
Disulfide bondi443 ↔ 454UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PeptideAtlasiC9JIZ6
PRIDEiC9JIZ6

Expressioni

Gene expression databases

BgeeiENSG00000197746
ExpressionAtlasiC9JIZ6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JIZ6
SMRiC9JIZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 58Saposin A-typeInterPro annotationAdd BLAST41
Domaini59 – 142Saposin B-typeInterPro annotationAdd BLAST84
Domaini194 – 278Saposin B-typeInterPro annotationAdd BLAST85
Domaini314 – 395Saposin B-typeInterPro annotationAdd BLAST82
Domaini408 – 489Saposin B-typeInterPro annotationAdd BLAST82
Domaini491 – 527Saposin A-typeInterPro annotationAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 158Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
GeneTreeiENSGT00530000063434
HOGENOMiHOG000049216
OMAiCKNYINQ
OrthoDBiEOG091G0K86

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR021165 Saposin_chordata
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 2 hits
PF05184 SapB_1, 4 hits
PF03489 SapB_2, 4 hits
PIRSFiPIRSF002431 Saposin, 1 hit
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 2 hits
SM00741 SapB, 4 hits
SUPFAMiSSF47862 SSF47862, 4 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 2 hits
PS50015 SAP_B, 4 hits

Sequencei

Sequence statusi: Complete.

C9JIZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ
60 70 80 90 100
TVWNKPTVKS LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP
110 120 130 140 150
NMSASCKEIV DSYLPVILDI IKGEMSRPGE VCSALNLCES LQKHLAELNH
160 170 180 190 200
QKQLESNKIP ELDMTEVVAP FMANIPLLLY PQDGPRSKPQ PKDNGDVCQD
210 220 230 240 250
CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI CKNYISQYSE
260 270 280 290 300
IAIQMMMHMS LQQPKEICAL VGFCDEVKEM PMQTLVPAKV ASKNVIPALE
310 320 330 340 350
LVEPIKKHEV PAKSDVYCEV CEFLVKEVTK LIDNNKTEKE ILDAFDKMCS
360 370 380 390 400
KLPKSLSEEC QEVVDTYGSS ILSILLEEVS PELVCSMLHL CSGTRLPALT
410 420 430 440 450
VHVTQPKDGG FCEVCKKLVG YLDRNLEKNS TKQEILAALE KGCSFLPDPY
460 470 480 490 500
QKQCDQFVAE YEPVLIEILV EVMDPSFVCL KIGACPSAHK PLLGTEKCIW
510 520
GPSYWCQNTE TAAQCNAVEH CKRHVWN
Length:527
Mass (Da):58,441
Last modified:October 29, 2014 - v2
Checksum:iD7FDB9DC50FA2F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073370 Genomic DNA No translation available.
AL731541 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000394934; ENSP00000378392; ENSG00000197746
UCSCiuc057twt.1 human

Similar proteinsi

Entry informationi

Entry nameiC9JIZ6_HUMAN
AccessioniPrimary (citable) accession number: C9JIZ6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: March 28, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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