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Protein

Transmembrane protein 238

Gene

TMEM238

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 238
Gene namesi
Name:TMEM238
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:40042. TMEM238.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 69ExtracellularSequence analysisAdd BLAST12
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 176CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000233493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135401 – 176Transmembrane protein 238Add BLAST176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei175PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiC9JI98.
PaxDbiC9JI98.
PRIDEiC9JI98.

PTM databases

iPTMnetiC9JI98.
PhosphoSitePlusiC9JI98.

Expressioni

Gene expression databases

BgeeiENSG00000233493.

Structurei

3D structure databases

ProteinModelPortaliC9JI98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 51Ala-richAdd BLAST50

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J41J. Eukaryota.
ENOG410YPH6. LUCA.
GeneTreeiENSGT00390000013421.
HOGENOMiHOG000169144.
InParanoidiC9JI98.
OMAiRANRAPQ.
OrthoDBiEOG091G12QS.
PhylomeDBiC9JI98.
TreeFamiTF339060.

Family and domain databases

InterProiIPR029365. TMEM238.
[Graphical view]
PfamiPF15125. TMEM238. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JI98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA
60 70 80 90 100
ALLTGVFAQL QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE
110 120 130 140 150
LERDYGLRPS ALARLARKLS RRWSAPAAAG QRPAPGSRRA RRAARAPPPP
160 170
AAGSRRVRLQ LATLEAGPGA AGAGSE
Length:176
Mass (Da):18,040
Last modified:November 3, 2009 - v1
Checksum:i323ABC220EC3506C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14P → S in BC052596 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA. No translation available.
BC052596 mRNA. No translation available.
CCDSiCCDS54323.1.
RefSeqiNP_001177693.1. NM_001190764.1.
UniGeneiHs.534672.

Genome annotation databases

EnsembliENST00000444469; ENSP00000416154; ENSG00000233493.
GeneIDi388564.
KEGGihsa:388564.
UCSCiuc002qku.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020922 Genomic DNA. No translation available.
BC052596 mRNA. No translation available.
CCDSiCCDS54323.1.
RefSeqiNP_001177693.1. NM_001190764.1.
UniGeneiHs.534672.

3D structure databases

ProteinModelPortaliC9JI98.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiC9JI98.
PhosphoSitePlusiC9JI98.

Proteomic databases

MaxQBiC9JI98.
PaxDbiC9JI98.
PRIDEiC9JI98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000444469; ENSP00000416154; ENSG00000233493.
GeneIDi388564.
KEGGihsa:388564.
UCSCiuc002qku.4. human.

Organism-specific databases

CTDi388564.
GeneCardsiTMEM238.
HGNCiHGNC:40042. TMEM238.
neXtProtiNX_C9JI98.
OpenTargetsiENSG00000233493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J41J. Eukaryota.
ENOG410YPH6. LUCA.
GeneTreeiENSGT00390000013421.
HOGENOMiHOG000169144.
InParanoidiC9JI98.
OMAiRANRAPQ.
OrthoDBiEOG091G12QS.
PhylomeDBiC9JI98.
TreeFamiTF339060.

Miscellaneous databases

PROiC9JI98.

Gene expression databases

BgeeiENSG00000233493.

Family and domain databases

InterProiIPR029365. TMEM238.
[Graphical view]
PfamiPF15125. TMEM238. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM238_HUMAN
AccessioniPrimary (citable) accession number: C9JI98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 3, 2009
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.