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C9JI98 (TM238_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 238
Gene names
Name:TMEM238
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Transmembrane protein 238
PRO_0000413540

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 6912Extracellular Potential
Transmembrane70 – 9021Helical; Potential
Topological domain91 – 17686Cytoplasmic Potential
Compositional bias2 – 5150Ala-rich

Amino acid modifications

Modified residue1751Phosphoserine Ref.3

Experimental info

Sequence conflict141P → S in BC052596. Ref.2

Sequences

Sequence LengthMass (Da)Tools
C9JI98 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 323ABC220EC3506C

FASTA17618,040
        10         20         30         40         50         60 
MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA ALLTGVFAQL 

        70         80         90        100        110        120 
QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE LERDYGLRPS ALARLARKLS 

       130        140        150        160        170 
RRWSAPAAAG QRPAPGSRRA RRAARAPPPP AAGSRRVRLQ LATLEAGPGA AGAGSE 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-176.
Tissue: Mammary carcinoma.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC020922 Genomic DNA. No translation available.
BC052596 mRNA. No translation available.
CCDSCCDS54323.1.
RefSeqNP_001177693.1. NM_001190764.1.
UniGeneHs.534672.

3D structure databases

ProteinModelPortalC9JI98.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteC9JI98.

Proteomic databases

MaxQBC9JI98.
PaxDbC9JI98.
PRIDEC9JI98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000444469; ENSP00000416154; ENSG00000233493.
GeneID388564.
KEGGhsa:388564.
UCSCuc002qku.3. human.

Organism-specific databases

CTD388564.
GeneCardsGC19M055891.
HGNCHGNC:40042. TMEM238.
neXtProtNX_C9JI98.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG78806.
HOGENOMHOG000169144.
OMAFRIPNIR.
OrthoDBEOG77HDHK.
PhylomeDBC9JI98.
TreeFamTF339060.

Gene expression databases

BgeeC9JI98.

Family and domain databases

InterProIPR029365. TMEM238.
[Graphical view]
PfamPF15125. TMEM238. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio102163.
PROC9JI98.

Entry information

Entry nameTM238_HUMAN
AccessionPrimary (citable) accession number: C9JI98
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM