C9JI98 (TM238_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 238

Gene names

Name:

TMEM238

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Transmembrane protein 238		PRO_0000413540
Regions
	Topological domain	1 – 36	36	Cytoplasmic Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Topological domain	58 – 69	12	Extracellular Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Topological domain	91 – 176	86	Cytoplasmic Potential
	Compositional bias	2 – 51	50	Ala-rich
Amino acid modifications
	Modified residue	175	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	14	1	P → S in BC052596. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	C9JI98 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 323ABC220EC3506C	FASTA	176	18,040
	10 20 30 40 50 60 MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA ALLTGVFAQL 70 80 90 100 110 120 QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE LERDYGLRPS ALARLARKLS 130 140 150 160 170 RRWSAPAAAG QRPAPGSRRA RRAARAPPPP AAGSRRVRLQ LATLEAGPGA AGAGSE

References

[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-176. Tissue: Mammary carcinoma.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, MASS SPECTROMETRY. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC020922 Genomic DNA. No translation available. BC052596 mRNA. No translation available.
IPI	IPI00373972.
RefSeq	NP_001177693.1. NM_001190764.1.
UniGene	Hs.534672.
3D structure databases
ProteinModelPortal	C9JI98.
ModBase	Search...
PTM databases
PhosphoSite	C9JI98.
Proteomic databases
PaxDb	C9JI98.
PRIDE	C9JI98.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000444469; ENSP00000416154; ENSG00000233493.
GeneID	388564.
KEGG	hsa:388564.
UCSC	uc002qku.3. human.
Organism-specific databases
CTD	388564.
GeneCards	GC19M055891.
HGNC	HGNC:40042. TMEM238.
neXtProt	NX_C9JI98.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78806.
HOGENOM	HOG000169144.
OMA	AVCASQG.
OrthoDB	EOG4KSPMH.
Gene expression databases
Bgee	C9JI98.
Family and domain databases
ProtoNet	Search...
Other
NextBio	102163.

Entry information

Entry name

TM238_HUMAN

Accession

Primary (citable) accession number: C9JI98

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	November 3, 2009
Last modified:	March 6, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.