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C9JI98

- TM238_HUMAN

UniProt

C9JI98 - TM238_HUMAN

Protein

Transmembrane protein 238

Gene

TMEM238

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 238
    Gene namesi
    Name:TMEM238
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:40042. TMEM238.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Transmembrane protein 238PRO_0000413540Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei175 – 1751Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiC9JI98.
    PaxDbiC9JI98.
    PRIDEiC9JI98.

    PTM databases

    PhosphoSiteiC9JI98.

    Expressioni

    Gene expression databases

    BgeeiC9JI98.

    Structurei

    3D structure databases

    ProteinModelPortaliC9JI98.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 6912ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini91 – 17686CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 5150Ala-richAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG78806.
    HOGENOMiHOG000169144.
    OMAiFRIPNIR.
    OrthoDBiEOG77HDHK.
    PhylomeDBiC9JI98.
    TreeFamiTF339060.

    Family and domain databases

    InterProiIPR029365. TMEM238.
    [Graphical view]
    PfamiPF15125. TMEM238. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C9JI98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAPAVCAS QGSPPGAPSA PAAAPAPAAG LGRCRMALLL AVALDVAGMA    50
    ALLTGVFAQL QVRGRDFGDL LIYSGALLVF LSLLGWILWY TGNIEISRQE 100
    LERDYGLRPS ALARLARKLS RRWSAPAAAG QRPAPGSRRA RRAARAPPPP 150
    AAGSRRVRLQ LATLEAGPGA AGAGSE 176
    Length:176
    Mass (Da):18,040
    Last modified:November 3, 2009 - v1
    Checksum:i323ABC220EC3506C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141P → S in BC052596. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020922 Genomic DNA. No translation available.
    BC052596 mRNA. No translation available.
    CCDSiCCDS54323.1.
    RefSeqiNP_001177693.1. NM_001190764.1.
    UniGeneiHs.534672.

    Genome annotation databases

    EnsembliENST00000444469; ENSP00000416154; ENSG00000233493.
    GeneIDi388564.
    KEGGihsa:388564.
    UCSCiuc002qku.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020922 Genomic DNA. No translation available.
    BC052596 mRNA. No translation available.
    CCDSi CCDS54323.1.
    RefSeqi NP_001177693.1. NM_001190764.1.
    UniGenei Hs.534672.

    3D structure databases

    ProteinModelPortali C9JI98.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei C9JI98.

    Proteomic databases

    MaxQBi C9JI98.
    PaxDbi C9JI98.
    PRIDEi C9JI98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000444469 ; ENSP00000416154 ; ENSG00000233493 .
    GeneIDi 388564.
    KEGGi hsa:388564.
    UCSCi uc002qku.3. human.

    Organism-specific databases

    CTDi 388564.
    GeneCardsi GC19M055891.
    HGNCi HGNC:40042. TMEM238.
    neXtProti NX_C9JI98.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78806.
    HOGENOMi HOG000169144.
    OMAi FRIPNIR.
    OrthoDBi EOG77HDHK.
    PhylomeDBi C9JI98.
    TreeFami TF339060.

    Miscellaneous databases

    NextBioi 102163.
    PROi C9JI98.

    Gene expression databases

    Bgeei C9JI98.

    Family and domain databases

    InterProi IPR029365. TMEM238.
    [Graphical view ]
    Pfami PF15125. TMEM238. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-176.
      Tissue: Mammary carcinoma.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiTM238_HUMAN
    AccessioniPrimary (citable) accession number: C9JI98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM

    External Data

    Dasty 3