ID   C9JHJ7_HUMAN            Unreviewed;        87 AA.
AC   C9JHJ7; A0A0A6YYV0; A0A0K0K1H1; C9K064;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   SubName: Full=Activin A receptor type 1 {ECO:0000313|Ensembl:ENSP00000403006.1};
DE   Flags: Fragment;
GN   Name=ACVR1 {ECO:0000313|Ensembl:ENSP00000403006.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403006.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403006.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000403006.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; AC013731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC019186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JHJ7; -.
DR   SMR; C9JHJ7; -.
DR   MassIVE; C9JHJ7; -.
DR   MaxQB; C9JHJ7; -.
DR   PeptideAtlas; C9JHJ7; -.
DR   ProteomicsDB; 10226; -.
DR   Antibodypedia; 2371; 694 antibodies from 41 providers.
DR   Ensembl; ENST00000412025.5; ENSP00000403006.1; ENSG00000115170.16.
DR   UCSC; uc061otu.1; human.
DR   HGNC; HGNC:171; ACVR1.
DR   VEuPathDB; HostDB:ENSG00000115170; -.
DR   GeneTree; ENSGT00940000160160; -.
DR   HOGENOM; CLU_2746627_0_0_1; -.
DR   OMA; VFERGCI; -.
DR   ChiTaRS; ACVR1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000115170; Expressed in cartilage tissue and 209 other cell types or tissues.
DR   ExpressionAtlas; C9JHJ7; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   Gene3D; 2.10.60.10; CD59; 1.
DR   InterPro; IPR000472; Activin_recp.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF01064; Activin_recp; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:C9JHJ7,
KW   ECO:0007829|MaxQB:C9JHJ7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..87
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009951688"
FT   DOMAIN          33..87
FT                   /note="Activin types I and II receptor"
FT                   /evidence="ECO:0000259|Pfam:PF01064"
FT   NON_TER         87
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000403006.1"
SQ   SEQUENCE   87 AA;  9604 MW;  0F387E9091863EF6 CRC64;
     MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN
     DGFHVYQKGC FQVYEQGKMT CKTPPSP
//