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Protein
Submitted name:

Seizure protein 6 homolog

Gene

SEZ6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Seizure protein 6 homologImported
Gene namesi
Name:SEZ6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:15955. SEZ6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei926 – 948HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500566921620 – 994Sequence analysisAdd BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi416 ↔ 443PROSITE-ProRule annotation
Disulfide bondi738 ↔ 765PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiC9JFF1.
PeptideAtlasiC9JFF1.
PRIDEiC9JFF1.

Expressioni

Gene expression databases

BgeeiENSG00000063015.
ExpressionAtlasiC9JFF1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JFF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini355 – 414Sushi (CCP/SCR)InterPro annotationAdd BLAST60
Domaini416 – 527CUBInterPro annotationAdd BLAST112
Domaini530 – 591Sushi (CCP/SCR)InterPro annotationAdd BLAST62
Domaini593 – 704CUBInterPro annotationAdd BLAST112
Domaini708 – 767Sushi (CCP/SCR)InterPro annotationAdd BLAST60
Domaini769 – 832Sushi (CCP/SCR)InterPro annotationAdd BLAST64
Domaini836 – 897Sushi (CCP/SCR)InterPro annotationAdd BLAST62

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IS3V. Eukaryota.
ENOG410YA6K. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000206919.
OrthoDBiEOG091G019A.

Family and domain databases

CDDicd00033. CCP. 5 hits.
cd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 3 hits.
InterProiView protein in InterPro
IPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00431. CUB. 2 hits.
PF00084. Sushi. 5 hits.
SMARTiView protein in SMART
SM00032. CCP. 5 hits.
SM00042. CUB. 2 hits.
SUPFAMiSSF49854. SSF49854. 3 hits.
SSF57535. SSF57535. 5 hits.
PROSITEiView protein in PROSITE
PS01180. CUB. 2 hits.
PS50923. SUSHI. 5 hits.

Sequencei

Sequence statusi: Complete.

C9JFF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPVALLLLP SLLALLAHGL SLEAPTVGKG QAPGIEETDG ELTAAPTPEQ
60 70 80 90 100
PERGVHFVTT APTLKLLNHH PLLEEFLQEG LEKGDEELRP ALPFQPDPPA
110 120 130 140 150
PFTPSPLPRL ANQDSRPVFT SPTPAMAAVP TQPQSKEGPW SPESESPMLR
160 170 180 190 200
ITAPLPPGPS MAVPTLGPGE IASTTPPSRA WTPTQEGPGD MGRPWVAEVV
210 220 230 240 250
SQGAGIGIQG TITSSTASGD DEETTTTTTI ITTTITTVQT PGPCSWNFSG
260 270 280 290 300
PEGSLDSPTD LSSPTDVGLD CFFYISVYPG YGVEIKVQNI SLREGETVTV
310 320 330 340 350
EGLGGPDPLP LANQSFLLRG QVIRSPTHQA ALRFQSLPPP AGPGTFHFHY
360 370 380 390 400
QAYLLSCHFP RRPAYGDVTV TSLHPGGSAR FHCATGYQLK GARHLTCLNA
410 420 430 440 450
TQPFWDSKEP VCIGECPGVI RNATTGRIVS PGFPGNYSNN LTCHWLLEAP
460 470 480 490 500
EGQRLHLHFE KVSLAEDDDR LIIRNGDNVE APPVYDSYEV EYLPIEGLLS
510 520 530 540 550
SGKHFFVELS TDSSGAAAGM ALRYEAFQQG HCYEPFVKYG NFSSSTPTYP
560 570 580 590 600
VGTTVEFSCD PGYTLEQGSI IIECVDPHDP QWNETEPACR AVCSGEITDS
610 620 630 640 650
AGVVLSPNWP EPYGRGQDCI WGVHVEEDKR IMLDIRVLRI GPGDVLTFYD
660 670 680 690 700
GDDLTARVLG QYSGPRSHFK LFTSMADVTI QFQSDPGTSV LGYQQGFVIH
710 720 730 740 750
FFEVPRNDTC PELPEIPNGW KSPSQPELVH GTVVTYQCYP GYQVVGSSVL
760 770 780 790 800
MCQWDLTWSE DLPSCQRVTS CHDPGDVEHS RRLISSPKFP VGATVQYICD
810 820 830 840 850
QGFVLMGSSI LTCHDRQAGS PKWSDRAPKC LLEQLKPCHG LSAPENGARS
860 870 880 890 900
PEKQLHPAGA TIHFSCAPGY VLKGQASIKC VPGHPSHWSD PPPICRAASL
910 920 930 940 950
DGSTTVAAWM VAKAPAASST LDAAHIAAAI FLPLVAMVLL VGGVYFYFSR
960 970 980 990
LQGKSSLQLP RPRPRPYNRI TIESAFDNPT YETGSLSFAG DERI
Length:994
Mass (Da):107,374
Last modified:October 29, 2014 - v2
Checksum:i3863BCCBDDABCC22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024267 Genomic DNA. No translation available.
AC024619 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000335960; ENSP00000337407; ENSG00000063015.
UCSCiuc060dhh.1. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiC9JFF1_HUMAN
AccessioniPrimary (citable) accession number: C9JFF1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: July 5, 2017
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported