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Protein

Malate dehydrogenase

Gene

MDH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:MDH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000014641.17
HGNCiHGNC:6970 MDH1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000014641

PTM / Processingi

Proteomic databases

MaxQBiC9JF79
PeptideAtlasiC9JF79
PRIDEiC9JF79

Expressioni

Gene expression databases

BgeeiENSG00000014641
ExpressionAtlasiC9JF79 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JF79
SMRiC9JF79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 170Ldh_1_NInterPro annotationAdd BLAST147
Domaini174 – 209Ldh_1_CInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1496 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00530000063410
HOGENOMiHOG000220953

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Fragment.

C9JF79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRCSYFPKD VTVFDKDDKS EPIRVLVTGA AGQIAYSLLY SIGNGSVFGK
60 70 80 90 100
DQPIILVLLD ITPMMGVLDG VLMELQDCAL PLLKDVIATD KEDVAFKDLD
110 120 130 140 150
VAILVGSMPR REGMERKDLL KANVKIFKSQ GAALDKYAKK SVKVIVVGNP
160 170 180 190 200
ANTNCLTASK SAPSIPKENF SCLTRLDHNR AKAQIALKLG VTANDVKNVI
210 220
IWGNHSSTQY PDVNHAKVKL QG
Length:222
Mass (Da):24,199
Last modified:November 3, 2009 - v1
Checksum:iFE98A998F9584F0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei222Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016734 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000432309; ENSP00000410073; ENSG00000014641
UCSCiuc061jro.1 human

Similar proteinsi

Entry informationi

Entry nameiC9JF79_HUMAN
AccessioniPrimary (citable) accession number: C9JF79
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health