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Protein

Malate dehydrogenase

Gene

MDH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:MDH1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000014641.17.
HGNCiHGNC:6970. MDH1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000014641.

PTM / Processingi

Proteomic databases

MaxQBiC9JF79.
PaxDbiC9JF79.
PeptideAtlasiC9JF79.
PRIDEiC9JF79.

Expressioni

Gene expression databases

BgeeiENSG00000014641.
ExpressionAtlasiC9JF79. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JF79.
SMRiC9JF79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 170Ldh_1_NInterPro annotationAdd BLAST147
Domaini174 – 209Ldh_1_CInterPro annotationAdd BLAST36

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1496. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00530000063410.
HOGENOMiHOG000220953.

Family and domain databases

InterProiView protein in InterPro
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JF79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRCSYFPKD VTVFDKDDKS EPIRVLVTGA AGQIAYSLLY SIGNGSVFGK
60 70 80 90 100
DQPIILVLLD ITPMMGVLDG VLMELQDCAL PLLKDVIATD KEDVAFKDLD
110 120 130 140 150
VAILVGSMPR REGMERKDLL KANVKIFKSQ GAALDKYAKK SVKVIVVGNP
160 170 180 190 200
ANTNCLTASK SAPSIPKENF SCLTRLDHNR AKAQIALKLG VTANDVKNVI
210 220
IWGNHSSTQY PDVNHAKVKL QG
Length:222
Mass (Da):24,199
Last modified:November 3, 2009 - v1
Checksum:iFE98A998F9584F0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei222Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016734 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000432309; ENSP00000410073; ENSG00000014641.
UCSCiuc061jro.1. human.

Similar proteinsi

Entry informationi

Entry nameiC9JF79_HUMAN
AccessioniPrimary (citable) accession number: C9JF79
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: September 27, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported