C9JEW8 (C9JEW8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Probable ATP-dependent RNA helicase DHX40 Ensembl ENSP00000396039

Gene names

Name:

DHX40 Ensembl ENSP00000396039

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000396039

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	731 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 helicase ATP-binding domain. SAAS SAAS007502 Contains 1 helicase C-terminal domain. SAAS SAAS007502
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000396039

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Helicase RuleBase RU000452 Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C9JEW8 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: 86CDE28F202750CC	FASTA	731	83,190
	10 20 30 40 50 60 MIGVTQPRKV AAISVAQRVA EEMKCTLGSK VGYQVRFDDC SSKETAIKYM TDGCLLKHIL 70 80 90 100 110 120 GDPNLTKFSV IILDEAHERT LTTDILFGLL KKLFQEKSPN RKEHLKVVVM SATMELAKLS 130 140 150 160 170 180 AFFGNCPIFD IPGRLYPVRE KFCNLIGPRD RENTAYIQAI VKVTMDIHLN EMAGDILVFL 190 200 210 220 230 240 TGQFEIEKSC ELLFQMAESV DYDYDVQDTT LDGLLILPCY GSMTTVSQTS LTFVTHIQIM 250 260 270 280 290 300 KQISENQHSL TGLTIAGITG VSHHARPRNM TCNEKLNQQR RIFLPPPPGI RKCVISTNIS 310 320 330 340 350 360 ATSLTIDGIR YVVDGGFVKQ LNHNPRLGLD ILEVVPISKS EALQRSGRAG RTSSGKCFRI 370 380 390 400 410 420 YSKDFWNQCM PDHVIPEIKR TSLTSVVLTL KCLAIHDVIR FPYLDPPNER LILEALKQLY 430 440 450 460 470 480 QCDAIDRSGH VTRLGLSMVE FPLPPHLTCA VIKAASLDCE DLLLPIAAML SVENVFIRPV 490 500 510 520 530 540 DPEYQKEAEQ RHRELAAKAG GFNDFATLAV IFEQCKSSGA PASWCQKHWI HWRCLFSAFR 550 560 570 580 590 600 VEAQLRELIR KLKQQSDFPK ETFEGPKHEV LRRCLCAGYF KNVARRSVGR TFCTMDGRGS 610 620 630 640 650 660 PVHIHPSSAL HEQETKLEWI IFHEVLVTTK VYARIVCPIR YEWVRDLLPK LHEFNAHDLS 670 680 690 700 710 720 SVARREVRED ARRRWTNKEN VKQLKDGISK DVLKKMQRRN DDKSISDARA RFLERKQQRT 730 QDHSDTRKET G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004167 Genomic DNA. No translation available. AC091271 Genomic DNA. No translation available.
IPI	IPI00789290.
3D structure databases
ProteinModelPortal	C9JEW8.
SMR	C9JEW8. Positions 2-673.
ModBase	Search...
Protein-protein interaction databases
STRING	C9JEW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000451169; ENSP00000396039; ENSG00000108406.
Organism-specific databases
HGNC	HGNC:18018. DHX40.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000175261.
Gene expression databases
ArrayExpress	C9JEW8.
Bgee	C9JEW8.
Family and domain databases
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR011709. DUF1605. IPR007502. Helicase-assoc_dom. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF04408. HA2. 1 hit. PF00271. Helicase_C. 1 hit. PF07717. OB_NTP_bind. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00847. HA2. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DHX40. human.
NextBio	35486250.

Entry information

Entry name

C9JEW8_HUMAN

Accession

Primary (citable) accession number: C9JEW8

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	June 28, 2011
Last modified:	May 1, 2013
This is version 26 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.