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C9JEW8

- C9JEW8_HUMAN

UniProt

C9JEW8 - C9JEW8_HUMAN

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Protein
Submitted name: Probable ATP-dependent RNA helicase DHX40
Gene
DHX40
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Probable ATP-dependent RNA helicase DHX40Imported
Gene namesi
Name:DHX40Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:18018. DHX40.

PTM / Processingi

Proteomic databases

MaxQBiC9JEW8.

Expressioni

Gene expression databases

ArrayExpressiC9JEW8.
BgeeiC9JEW8.

Structurei

3D structure databases

ProteinModelPortaliC9JEW8.
SMRiC9JEW8. Positions 2-673.

Family & Domainsi

Sequence similaritiesi

Contains helicase ATP-binding domain.SAAS annotations
Contains helicase C-terminal domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000175261.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JEW8-1 [UniParc]FASTAAdd to Basket

« Hide

MIGVTQPRKV AAISVAQRVA EEMKCTLGSK VGYQVRFDDC SSKETAIKYM    50
TDGCLLKHIL GDPNLTKFSV IILDEAHERT LTTDILFGLL KKLFQEKSPN 100
RKEHLKVVVM SATMELAKLS AFFGNCPIFD IPGRLYPVRE KFCNLIGPRD 150
RENTAYIQAI VKVTMDIHLN EMAGDILVFL TGQFEIEKSC ELLFQMAESV 200
DYDYDVQDTT LDGLLILPCY GSMTTVSQTS LTFVTHIQIM KQISENQHSL 250
TGLTIAGITG VSHHARPRNM TCNEKLNQQR RIFLPPPPGI RKCVISTNIS 300
ATSLTIDGIR YVVDGGFVKQ LNHNPRLGLD ILEVVPISKS EALQRSGRAG 350
RTSSGKCFRI YSKDFWNQCM PDHVIPEIKR TSLTSVVLTL KCLAIHDVIR 400
FPYLDPPNER LILEALKQLY QCDAIDRSGH VTRLGLSMVE FPLPPHLTCA 450
VIKAASLDCE DLLLPIAAML SVENVFIRPV DPEYQKEAEQ RHRELAAKAG 500
GFNDFATLAV IFEQCKSSGA PASWCQKHWI HWRCLFSAFR VEAQLRELIR 550
KLKQQSDFPK ETFEGPKHEV LRRCLCAGYF KNVARRSVGR TFCTMDGRGS 600
PVHIHPSSAL HEQETKLEWI IFHEVLVTTK VYARIVCPIR YEWVRDLLPK 650
LHEFNAHDLS SVARREVRED ARRRWTNKEN VKQLKDGISK DVLKKMQRRN 700
DDKSISDARA RFLERKQQRT QDHSDTRKET G 731
Length:731
Mass (Da):83,190
Last modified:June 28, 2011 - v2
Checksum:i86CDE28F202750CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004167 Genomic DNA. No translation available.
AC091271 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000451169; ENSP00000396039; ENSG00000108406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004167 Genomic DNA. No translation available.
AC091271 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali C9JEW8.
SMRi C9JEW8. Positions 2-673.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi C9JEW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000451169 ; ENSP00000396039 ; ENSG00000108406 .

Organism-specific databases

HGNCi HGNC:18018. DHX40.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000175261.

Miscellaneous databases

ChiTaRSi DHX40. human.
NextBioi 35486250.

Gene expression databases

ArrayExpressi C9JEW8.
Bgeei C9JEW8.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JEW8_HUMAN
AccessioniPrimary (citable) accession number: C9JEW8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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