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Protein
Submitted name:

Nuclear receptor corepressor 2

Gene

NCOR2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor corepressor 2Imported
Gene namesi
Name:NCOR2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7673. NCOR2.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196498.

PTM / Processingi

Proteomic databases

EPDiC9JE98.
MaxQBiC9JE98.
PaxDbiC9JE98.
PeptideAtlasiC9JE98.
PRIDEiC9JE98.

Expressioni

Gene expression databases

BgeeiENSG00000196498.
ExpressionAtlasiC9JE98. baseline and differential.
GenevisibleiC9JE98. HS.

Interactioni

Protein-protein interaction databases

IntActiC9JE98. 5 interactors.
STRINGi9606.ENSP00000384018.

Structurei

3D structure databases

ProteinModelPortaliC9JE98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini426 – 477SANTInterPro annotationAdd BLAST52
Domaini609 – 660SANTInterPro annotationAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili169 – 206Sequence analysisAdd BLAST38
Coiled coili514 – 547Sequence analysisAdd BLAST34
Coiled coili658 – 685Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1878. Eukaryota.
ENOG410YDXP. LUCA.
GeneTreeiENSGT00840000129748.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR031557. N-CoR_GPS2_interact.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF15784. GPS2_interact. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9JE98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA
60 70 80 90 100
SHLSPGSIIQ PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM
110 120 130 140 150
EFIESKRPRL ELLPDPLLRP SPLLATGQPA GSEDLTKDRS LTGKLEPVSP
160 170 180 190 200
PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD REITMVEQQI SKLKKKQQQL
210 220 230 240 250
EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA AHRILEGLGP
260 270 280 290 300
QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ
310 320 330 340 350
RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM
360 370 380 390 400
QRVGQRGSGL SMSAARSEHE VSEIIDGLSE QENLEKQMRQ LAVIPPMLYD
410 420 430 440 450
ADQQRIKFIN MNGLMADPMK VYKDRQVMNM WSEQEKETFR EKFMQHPKNF
460 470 480 490 500
GLIASFLERK TVAECVLYYY LTKKNENYKS LVRRSYRRRG KSQQQQQQQQ
510 520 530 540 550
QQQQQQQQQP MPRSSQEEKD EKEKEKEAEK EEEKPEVEND KEDLLKEKTD
560 570 580 590 600
DTSGEDNDEK EAVASKGRKT ANSQGRRKGR ITRSMANEAN SEEAITPQQS
610 620 630 640 650
AELASMELNE SSRWTEEEME TAKKGLLEHG RNWSAIARMV GSKTVSQCKN
660 670 680 690 700
FYFNYKKRQN LDEILQQHKL KMEKERNARR KKKKAPAAAS EEAAFPPVVE
710 720 730 740 750
DEEMEASGVS GNEEEMVEEA EATVNNSSDT ESIPSPHTEA AKDTGQNGPK
760 770 780 790 800
PPATLGADGP PPGPPTPPPE DIPAPTEPTP ASEATGAPTP PPAPPSPSAP
810 820 830 840 850
PPVVPKEEKE EETAAAPPVE EGEEQKPPAA EELAVDTGKA EEPVKSECTE
860 870 880 890 900
EAEEGPAKGK DAEAAEATAE GALKAEKKEG GSGRATTAKS SGAPQDSDSS
910 920 930 940 950
ATCSADEVDE AEGGDKNRLL SPRPSLLTPT GDPRANASPQ KPLDLKQLKQ
960 970 980 990 1000
RAAAIPPIQV TKVHEPPRED AAPTKPAPPA PPPPQNLQPE SDAPQQPGSS
1010 1020 1030 1040 1050
PRGKSRSPAP PADKEAEKPV FFPAFAAEAQ KLPGDPPCWT SGLPFPVPPR
1060 1070 1080 1090 1100
EVIKASPHAP DPSAFSYAPP GHPLPLGLHD TARPVLPRPP TISNPPPLIS
1110 1120 1130 1140 1150
SAKHPSVLER QIGAISQGMS VQLHVPYSEH AKAPVGPVTM GLPLPMDPKK
1160 1170 1180 1190 1200
LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL GSVPGGSITK
1210 1220 1230 1240 1250
GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED SPSRLDRGRE
1260 1270 1280 1290 1300
DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP PHETAAPKRT
1310 1320 1330 1340 1350
YDMMEGRVGR AISSASIEGL MGRAIPPERH SPHHLKEQHH IRGSITQGIP
1360 1370 1380 1390 1400
RSYVEAQEDY LRREAKLLKR EGTPPPPPPS RDLTEAYKTQ ALGPLKLKPA
1410 1420 1430 1440 1450
HEGLVATVKE AGRSIHEIPR EELRHTPELP LAPRPLKEGS ITQGTPLKYD
1460 1470 1480 1490 1500
TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE RACYEESLKS
1510 1520 1530 1540 1550
RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF AGHLPRGSPV
1560 1570 1580 1590 1600
TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV PEHHPHPISP
1610 1620 1630 1640 1650
YEHLLRGVSG VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY LPRHLAPNPT
1660 1670 1680 1690 1700
YPHLYPPYLI RGYPDTAALE NRQTIINDYI TSQQMHHNAA TAMAQRADML
1710 1720 1730 1740 1750
RGLSPRESSL ALNYAAGPRG IIDLSQVPHL PVLVPPTPGT PATAMDRLAY
1760 1770 1780 1790 1800
LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR DRERDRDRER
1810 1820 1830 1840 1850
EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS HSHAHQHSPI
1860 1870 1880 1890 1900
SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST SSPVRPAATF
1910 1920 1930 1940 1950
PPATHCPLGG TLDGVYPTLM EPVLLPKEAP RVARPERPRA DTGHAFLAKP
1960 1970 1980 1990 2000
PARSGLEPAS SPSKGSEPRP LVPPVSGHAT IARTPAKNLA PHHASPDPPA
2010 2020 2030 2040 2050
PPASASDPHR EKTQSKPFSI QELELRSLGY HGSSYSPEGV EPVSPVSSPS
2060 2070 2080 2090 2100
LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL PHLRPLPESQ
2110 2120 2130 2140 2150
PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ QLSAPLPAPL
2160 2170 2180 2190 2200
YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG KRSPEPNKTS
2210 2220 2230 2240 2250
VLGGGEDGIE PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE PSRMGSKSPG
2260 2270 2280 2290 2300
NTSQPPAFFS KLTESNSAMV KSKKQEINKK LNTHNRNEPE YNISQPGTEI
2310 2320 2330 2340 2350
FNMPAITGTG LMTYRSQAVQ EHASTNMGLE AIIRKALMGG GGKAKVSGRP
2360 2370 2380 2390 2400
SSRKAKSPAP GLASGDRPPS VSSVHSEGDC NRRTPLTNRV WEDRPSSAGS
2410 2420 2430 2440 2450
TPFPYNPLIM RLQAGVMASP PPPGLPAGSG PLAGPHHAWD EEPKPLLCSQ

YETLSDSE
Length:2,458
Mass (Da):268,043
Last modified:November 3, 2009 - v1
Checksum:i79476C5555074C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069261 Genomic DNA. No translation available.
AC073592 Genomic DNA. No translation available.
AC073916 Genomic DNA. No translation available.
RefSeqiNP_001070729.2. NM_001077261.3.
UniGeneiHs.137510.

Genome annotation databases

EnsembliENST00000404621; ENSP00000384202; ENSG00000196498.
GeneIDi9612.
UCSCiuc058uwt.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069261 Genomic DNA. No translation available.
AC073592 Genomic DNA. No translation available.
AC073916 Genomic DNA. No translation available.
RefSeqiNP_001070729.2. NM_001077261.3.
UniGeneiHs.137510.

3D structure databases

ProteinModelPortaliC9JE98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC9JE98. 5 interactors.
STRINGi9606.ENSP00000384018.

Proteomic databases

EPDiC9JE98.
MaxQBiC9JE98.
PaxDbiC9JE98.
PeptideAtlasiC9JE98.
PRIDEiC9JE98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404621; ENSP00000384202; ENSG00000196498.
GeneIDi9612.
UCSCiuc058uwt.1. human.

Organism-specific databases

CTDi9612.
HGNCiHGNC:7673. NCOR2.
OpenTargetsiENSG00000196498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1878. Eukaryota.
ENOG410YDXP. LUCA.
GeneTreeiENSGT00840000129748.

Miscellaneous databases

ChiTaRSiNCOR2. human.
GenomeRNAii9612.

Gene expression databases

BgeeiENSG00000196498.
ExpressionAtlasiC9JE98. baseline and differential.
GenevisibleiC9JE98. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR031557. N-CoR_GPS2_interact.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF15784. GPS2_interact. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51293. SANT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9JE98_HUMAN
AccessioniPrimary (citable) accession number: C9JE98
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.