ID   C9JE88_HUMAN            Unreviewed;       147 AA.
AC   C9JE88;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 2.
DT   27-MAR-2024, entry version 78.
DE   SubName: Full=Carboxypeptidase E {ECO:0000313|Ensembl:ENSP00000416601.1};
DE   Flags: Fragment;
GN   Name=CPE {ECO:0000313|Ensembl:ENSP00000416601.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416601.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000416601.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000416601.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
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DR   EMBL; AC012504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JE88; -.
DR   SMR; C9JE88; -.
DR   MassIVE; C9JE88; -.
DR   MaxQB; C9JE88; -.
DR   PeptideAtlas; C9JE88; -.
DR   ProteomicsDB; 9826; -.
DR   Antibodypedia; 16998; 388 antibodies from 36 providers.
DR   Ensembl; ENST00000431967.5; ENSP00000416601.1; ENSG00000109472.14.
DR   UCSC; uc063aty.1; human.
DR   HGNC; HGNC:2303; CPE.
DR   VEuPathDB; HostDB:ENSG00000109472; -.
DR   GeneTree; ENSGT00940000157158; -.
DR   OMA; WEQNRDS; -.
DR   ChiTaRS; CPE; human.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000109472; Expressed in type B pancreatic cell and 204 other cell types or tissues.
DR   ExpressionAtlas; C9JE88; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR11532:SF92; CARBOXYPEPTIDASE E; 1.
DR   PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   PRINTS; PR00765; CRBOXYPTASEA.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Proteomics identification {ECO:0007829|EPD:C9JE88,
KW   ECO:0007829|MaxQB:C9JE88};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          136..146
FT                   /note="Peptidase M14 carboxypeptidase A"
FT                   /evidence="ECO:0000259|PROSITE:PS00133"
FT   NON_TER         147
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000416601.1"
SQ   SEQUENCE   147 AA;  16596 MW;  593593E304006840 CRC64;
     MHGNEAVGRE LLIFLAQYLC NEYQKGNETI VNLIHSTRIH IMPSLNPDGF EKAASQPGEL
     KDWFVGRSNA QGIDLNRNFP DLDRIVYVNE KEGGPNNHLL KNMKKIVDQN TKLAPETKAV
     IHWIMDIPFV LSANLHGGDL VANYPYD
//