ID   C9JE56_HUMAN            Unreviewed;       228 AA.
AC   C9JE56;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=WD repeat-containing protein 76 {ECO:0000256|RuleBase:RU365004};
DE   Flags: Fragment;
GN   Name=WDR76 {ECO:0000313|Ensembl:ENSP00000404665.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000404665.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000404665.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000404665.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting
CC       that it acts as a specific reader of 5hmC.
CC       {ECO:0000256|RuleBase:RU365004}.
CC   -!- SUBUNIT: Interacts with CUL4A and/or CUL4B.
CC       {ECO:0000256|RuleBase:RU365004}.
CC   -!- SIMILARITY: Belongs to the WD repeat DDB2/WDR76 family.
CC       {ECO:0000256|RuleBase:RU365004}.
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DR   EMBL; AC018512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC023356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JE56; -.
DR   SMR; C9JE56; -.
DR   MassIVE; C9JE56; -.
DR   MaxQB; C9JE56; -.
DR   PeptideAtlas; C9JE56; -.
DR   ProteomicsDB; 9815; -.
DR   Antibodypedia; 52296; 82 antibodies from 22 providers.
DR   Ensembl; ENST00000452115.1; ENSP00000404665.1; ENSG00000092470.12.
DR   UCSC; uc059inv.1; human.
DR   HGNC; HGNC:25773; WDR76.
DR   VEuPathDB; HostDB:ENSG00000092470; -.
DR   GeneTree; ENSGT00510000048144; -.
DR   HOGENOM; CLU_1217158_0_0_1; -.
DR   OMA; DTVVRHN; -.
DR   ChiTaRS; WDR76; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000092470; Expressed in oocyte and 120 other cell types or tissues.
DR   ExpressionAtlas; C9JE56; baseline and differential.
DR   PANTHER; PTHR14773; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR14773:SF0; WD REPEAT-CONTAINING PROTEIN 76; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:C9JE56,
KW   ECO:0007829|MaxQB:C9JE56};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   WD repeat {ECO:0000256|RuleBase:RU365004}.
FT   REGION          28..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         228
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000404665.1"
SQ   SEQUENCE   228 AA;  25218 MW;  0C881BE0DE04811A CRC64;
     MCPKSLSEKN SNNEVACKKT KIKKTCRRII PPKMKNTSSK AESTLQNSSS AVHTESNKLQ
     PKRTADAMNL SVDVESSQDG DSDEDTTPSL DFSGLSPYER KRLKNISENA DFFASLQLSE
     SAARLREMIE KRQPPKSKRK KPKRENGIGC RRSMRLLKVD PSGVSLPAAP TPPTLVADET
     PLLPPGPLEM TSENQEDNNE RFKGFLHTWA GMSKPSSKNT EKGLSSIK
//