C9JE40 (PATL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PAT1 homolog 2

Alternative name(s):
PAT1-like protein 2
Protein PAT1 homolog a
Short name=Pat1a
Short name=hPat1a

Gene names

Name:

PATL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	RNA-binding protein that acts as a translational repressor By similarity.
Subunit structure	Interacts with LSM1. Ref.2
Subcellular location	Cytoplasm. Nucleus By similarity Ref.2.
Sequence similarities	Belongs to the PAT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cytoplasmic mRNA processing body assembly Inferred from electronic annotation. Source: Compara negative regulation of translation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.2. Source: UniProtKB cytoplasmic mRNA processing body Inferred from electronic annotation. Source: Compara nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	RNA binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 543	543	Protein PAT1 homolog 2		PRO_0000404577
Natural variations
	Natural variant	88	1	M → L. Corresponds to variant rs8026845 [ dbSNP | Ensembl ].		VAR_064549

Sequences

	Sequence		Length	Mass (Da)
	C9JE40 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 9CEBE851700D8DD6	FASTA	543	61,464
	10 20 30 40 50 60 MNCLEGPGKT CGPLASEEEL VSACQLEKEE ENEGEEEEEE EDEEDLDPDL DPDLEEEEND 70 80 90 100 110 120 LGDPAVLGAV HNTQRALLSS PGVKAPGMLG MSLASLHFLW QTLDYLSPIP FWPTFPSTSS 130 140 150 160 170 180 PAQHFGPRLP SPDPTLFCSL LTSWPPRFSH LTQLHPRHQR ILQQQQHSQT PSPPAKKPWS 190 200 210 220 230 240 QQPDPYANLM TRKEKDWVIK VQMVQLQSAK PRLDDYYYQE YYQKLEKKQA DEELLGRRNR 250 260 270 280 290 300 VESLKLVTPY IPKAEAYESV VRIEGSLGQV AVSTCFSPRR AIDAVPHGTQ EQDIEAASSQ 310 320 330 340 350 360 RLRVLYRIEK MFLQLLEIEE GWKYRPPPPC FSEQQSNQVE KLFQTLKTQE QNNLEEAADG 370 380 390 400 410 420 FLQVLSVRKG KALVARLLPF LPQDQAVTIL LAITHHLPLL VRRDVADQAL QMLFKPLGKC 430 440 450 460 470 480 ISHLTLHELL QGLQGLTLLP PGSSERPVTV VLQNQFGISL LYALLSHGEQ LVSLHSSLEE 490 500 510 520 530 540 PNSDHTAWTD MVVLIAWEIA QMPTASLAEP LAFPSNLLPL FCHHVDKQLV QQLEARMEFA WIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies." Ozgur S., Chekulaeva M., Stoecklin G. Mol. Cell. Biol. 30:4308-4323(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LSM1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009996 Genomic DNA. No translation available. AC025270 Genomic DNA. No translation available.
IPI	IPI00737028.
RefSeq	NP_001138584.1. NM_001145112.1.
UniGene	Hs.11594.
3D structure databases
ProteinModelPortal	C9JE40.
SMR	C9JE40. Positions 300-538.
ModBase	Search...
PTM databases
PhosphoSite	C9JE40.
Proteomic databases
PaxDb	C9JE40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000434130; ENSP00000416673; ENSG00000229474. ENST00000560775; ENSP00000453915; ENSG00000229474.
GeneID	197135.
KEGG	hsa:197135.
UCSC	uc001zub.4. human.
Organism-specific databases
CTD	197135.
GeneCards	GC15M044957.
H-InvDB	HIX0026804.
HGNC	HGNC:33630. PATL2.
MIM	614661. gene.
neXtProt	NX_C9JE40.
PharmGKB	PA164724408.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG126064.
HOGENOM	HOG000231836.
OMA	MVQLQSA.
OrthoDB	EOG4TB4CB.
Gene expression databases
ArrayExpress	C9JE40.
Bgee	C9JE40.
Family and domain databases
InterPro	IPR019167. Topo_II-assoc_PAT1. [Graphical view]
Pfam	PF09770. PAT1. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	197135.
NextBio	89612.
SOURCE	Search...

Entry information

Entry name

PATL2_HUMAN

Accession

Primary (citable) accession number: C9JE40

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.