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C9JDP6 (CLD25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative claudin-25
Gene names
Name:CLDN25
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the claudin family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Membrane
Tight junction
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

tight junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Putative claudin-25
PRO_0000395403

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 8150Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 12422Cytoplasmic Potential
Transmembrane125 – 14521Helical; Potential
Topological domain146 – 16419Extracellular Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 22944Cytoplasmic Potential

Natural variations

Natural variant2191H → Y.
Corresponds to variant rs35111413 [ dbSNP | Ensembl ].
VAR_063401

Sequences

Sequence LengthMass (Da)Tools
C9JDP6 [UniParc].

Last modified November 3, 2009. Version 1.
Checksum: 86EC6AEE87BCA151

FASTA22925,394
        10         20         30         40         50         60 
MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI WEVCVDREEV 

        70         80         90        100        110        120 
ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF GSECFQFHRI RWVFKRRLGL 

       130        140        150        160        170        180 
LGRTLEASAS ATTLLPVSWV AHATIQDFWD DSIPDIIPRW EFGGALYLGW AAGIFLALGG 

       190        200        210        220 
LLLIFSACLG KEDVPFPLMA GPTVPLSCAP VEESDGSFHL MLRPRNLVI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP003170 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67230.1.
CCDSCCDS44736.1.
RefSeqNP_001094859.1. NM_001101389.1.
UniGeneHs.705360.

3D structure databases

ProteinModelPortalC9JDP6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000396304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000453129; ENSP00000396304; ENSG00000228607.
GeneID644672.
KEGGhsa:644672.
UCSCuc009yyw.1. human.

Organism-specific databases

CTD644672.
GeneCardsGC11P113650.
HGNCHGNC:37218. CLDN25.
HPAHPA053555.
neXtProtNX_C9JDP6.
PharmGKBPA165543379.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40943.
HOGENOMHOG000220937.
KOK06087.
OMALPQWKTL.
OrthoDBEOG7VMP6V.
PhylomeDBC9JDP6.
TreeFamTF331936.

Family and domain databases

InterProIPR006187. Claudin.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
ProtoNetSearch...

Other

NextBio116508.

Entry information

Entry nameCLD25_HUMAN
AccessionPrimary (citable) accession number: C9JDP6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM