C9JDP6 (CLD25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative claudin-25

Gene names

Name:

CLDN25

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.
Subcellular location	Cell junction › tight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the claudin family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Tight junction
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	Putative claudin-25		PRO_0000395403
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Topological domain	32 – 81	50	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Topological domain	103 – 124	22	Cytoplasmic Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Topological domain	146 – 164	19	Extracellular Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Topological domain	186 – 229	44	Cytoplasmic Potential
Natural variations
	Natural variant	219	1	H → Y. Corresponds to variant rs35111413 [ dbSNP | Ensembl ].		VAR_063401

Sequences

	Sequence		Length	Mass (Da)
	C9JDP6 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: 86EC6AEE87BCA151	FASTA	229	25,394
	10 20 30 40 50 60 MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI WEVCVDREEV 70 80 90 100 110 120 ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF GSECFQFHRI RWVFKRRLGL 130 140 150 160 170 180 LGRTLEASAS ATTLLPVSWV AHATIQDFWD DSIPDIIPRW EFGGALYLGW AAGIFLALGG 190 200 210 220 LLLIFSACLG KEDVPFPLMA GPTVPLSCAP VEESDGSFHL MLRPRNLVI

References

[1]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP003170 Genomic DNA. No translation available. CH471065 Genomic DNA. Translation: EAW67230.1.
IPI	IPI00737822.
RefSeq	NP_001094859.1. NM_001101389.1.
UniGene	Hs.705360.
3D structure databases
ProteinModelPortal	C9JDP6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000396304.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000453129; ENSP00000396304; ENSG00000228607.
GeneID	644672.
KEGG	hsa:644672.
UCSC	uc009yyw.1. human.
Organism-specific databases
CTD	644672.
GeneCards	GC11P113650.
HGNC	HGNC:37218. CLDN25.
HPA	HPA053555.
neXtProt	NX_C9JDP6.
PharmGKB	PA165543379.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40943.
HOGENOM	HOG000220937.
KO	K06087.
OMA	LPQWKTL.
OrthoDB	EOG4V4391.
Family and domain databases
InterPro	IPR006187. Claudin. IPR004031. PMP22/EMP/MP20/Claudin. [Graphical view]
PANTHER	PTHR12002. PTHR12002. 1 hit.
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01077. CLAUDIN.
ProtoNet	Search...
Other
NextBio	116508.

Entry information

Entry name

CLD25_HUMAN

Accession

Primary (citable) accession number: C9JDP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	November 3, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.