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C9JDP6

- CLD25_HUMAN

UniProt

C9JDP6 - CLD25_HUMAN

Protein

Putative claudin-25

Gene

CLDN25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative claudin-25
    Gene namesi
    Name:CLDN25
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:37218. CLDN25.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165543379.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Putative claudin-25PRO_0000395403Add
    BLAST

    Expressioni

    Organism-specific databases

    HPAiHPA053555.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000396304.

    Structurei

    3D structure databases

    ProteinModelPortaliC9JDP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 8150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16419ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22944CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40943.
    HOGENOMiHOG000220937.
    KOiK06087.
    OMAiLPQWKTL.
    OrthoDBiEOG7VMP6V.
    PhylomeDBiC9JDP6.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.

    Sequencei

    Sequence statusi: Complete.

    C9JDP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI    50
    WEVCVDREEV ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF 100
    GSECFQFHRI RWVFKRRLGL LGRTLEASAS ATTLLPVSWV AHATIQDFWD 150
    DSIPDIIPRW EFGGALYLGW AAGIFLALGG LLLIFSACLG KEDVPFPLMA 200
    GPTVPLSCAP VEESDGSFHL MLRPRNLVI 229
    Length:229
    Mass (Da):25,394
    Last modified:November 3, 2009 - v1
    Checksum:i86EC6AEE87BCA151
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191H → Y.
    Corresponds to variant rs35111413 [ dbSNP | Ensembl ].
    VAR_063401

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003170 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67230.1.
    CCDSiCCDS44736.1.
    RefSeqiNP_001094859.1. NM_001101389.1.
    UniGeneiHs.705360.

    Genome annotation databases

    EnsembliENST00000453129; ENSP00000396304; ENSG00000228607.
    GeneIDi644672.
    KEGGihsa:644672.
    UCSCiuc009yyw.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP003170 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67230.1 .
    CCDSi CCDS44736.1.
    RefSeqi NP_001094859.1. NM_001101389.1.
    UniGenei Hs.705360.

    3D structure databases

    ProteinModelPortali C9JDP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000396304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000453129 ; ENSP00000396304 ; ENSG00000228607 .
    GeneIDi 644672.
    KEGGi hsa:644672.
    UCSCi uc009yyw.1. human.

    Organism-specific databases

    CTDi 644672.
    GeneCardsi GC11P113650.
    HGNCi HGNC:37218. CLDN25.
    HPAi HPA053555.
    neXtProti NX_C9JDP6.
    PharmGKBi PA165543379.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40943.
    HOGENOMi HOG000220937.
    KOi K06087.
    OMAi LPQWKTL.
    OrthoDBi EOG7VMP6V.
    PhylomeDBi C9JDP6.
    TreeFami TF331936.

    Miscellaneous databases

    NextBioi 116508.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCLD25_HUMAN
    AccessioniPrimary (citable) accession number: C9JDP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3