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Protein

Putative claudin-25

Gene

CLDN25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative claudin-25
Gene namesi
Name:CLDN25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:37218. CLDN25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 8150ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 12422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Topological domaini146 – 16419ExtracellularSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Topological domaini186 – 22944CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165543379.

Polymorphism and mutation databases

BioMutaiCLDN25.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Putative claudin-25PRO_0000395403Add
BLAST

Expressioni

Organism-specific databases

HPAiHPA053555.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396304.

Structurei

3D structure databases

ProteinModelPortaliC9JDP6.
SMRiC9JDP6. Positions 9-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40943.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
InParanoidiC9JDP6.
KOiK06087.
OMAiLPQWKTL.
OrthoDBiEOG7VMP6V.
PhylomeDBiC9JDP6.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.

Sequencei

Sequence statusi: Complete.

C9JDP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSFRAKVQ LGGLLLSLLG WVCSCVTTIL PQWKTLNLEL NEMETWIMGI
60 70 80 90 100
WEVCVDREEV ATVCKAFESF LSLPQELQVA RILMVASHGL GLLGLLLCSF
110 120 130 140 150
GSECFQFHRI RWVFKRRLGL LGRTLEASAS ATTLLPVSWV AHATIQDFWD
160 170 180 190 200
DSIPDIIPRW EFGGALYLGW AAGIFLALGG LLLIFSACLG KEDVPFPLMA
210 220
GPTVPLSCAP VEESDGSFHL MLRPRNLVI
Length:229
Mass (Da):25,394
Last modified:November 3, 2009 - v1
Checksum:i86EC6AEE87BCA151
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191H → Y.
Corresponds to variant rs35111413 [ dbSNP | Ensembl ].
VAR_063401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003170 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67230.1.
CCDSiCCDS44736.1.
RefSeqiNP_001094859.1. NM_001101389.1.
UniGeneiHs.705360.

Genome annotation databases

EnsembliENST00000453129; ENSP00000396304; ENSG00000228607.
GeneIDi644672.
KEGGihsa:644672.
UCSCiuc009yyw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003170 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67230.1.
CCDSiCCDS44736.1.
RefSeqiNP_001094859.1. NM_001101389.1.
UniGeneiHs.705360.

3D structure databases

ProteinModelPortaliC9JDP6.
SMRiC9JDP6. Positions 9-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396304.

Polymorphism and mutation databases

BioMutaiCLDN25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453129; ENSP00000396304; ENSG00000228607.
GeneIDi644672.
KEGGihsa:644672.
UCSCiuc009yyw.1. human.

Organism-specific databases

CTDi644672.
GeneCardsiGC11P113650.
HGNCiHGNC:37218. CLDN25.
HPAiHPA053555.
neXtProtiNX_C9JDP6.
PharmGKBiPA165543379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40943.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
InParanoidiC9JDP6.
KOiK06087.
OMAiLPQWKTL.
OrthoDBiEOG7VMP6V.
PhylomeDBiC9JDP6.
TreeFamiTF331936.

Miscellaneous databases

GenomeRNAii644672.
NextBioi116508.

Family and domain databases

InterProiIPR006187. Claudin.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCLD25_HUMAN
AccessioniPrimary (citable) accession number: C9JDP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: November 3, 2009
Last modified: May 27, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.