ID   C9JDH2_HUMAN            Unreviewed;       128 AA.
AC   C9JDH2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Beta-crystallin A2 {ECO:0000256|ARBA:ARBA00040560};
DE   AltName: Full=Beta-A2 crystallin {ECO:0000256|ARBA:ARBA00042193};
DE   Flags: Fragment;
GN   Name=CRYBA2 {ECO:0000313|Ensembl:ENSP00000395120.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000395120.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000395120.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000395120.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Crystallins are the dominant structural components of the
CC       vertebrate eye lens. {ECO:0000256|ARBA:ARBA00003689}.
CC   -!- SUBUNIT: Homo/heterodimer, or complexes of higher-order. The structure
CC       of beta-crystallin oligomers seems to be stabilized through
CC       interactions between the N-terminal arms.
CC       {ECO:0000256|ARBA:ARBA00025922}.
CC   -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC       {ECO:0000256|ARBA:ARBA00009646}.
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DR   EMBL; AC097468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JDH2; -.
DR   SMR; C9JDH2; -.
DR   PeptideAtlas; C9JDH2; -.
DR   ProteomicsDB; 9723; -.
DR   Antibodypedia; 34295; 64 antibodies from 15 providers.
DR   Ensembl; ENST00000453769.1; ENSP00000395120.1; ENSG00000163499.12.
DR   UCSC; uc061spw.1; human.
DR   HGNC; HGNC:2395; CRYBA2.
DR   VEuPathDB; HostDB:ENSG00000163499; -.
DR   GeneTree; ENSGT00940000160306; -.
DR   HOGENOM; CLU_081883_3_0_1; -.
DR   OMA; SDCANIA; -.
DR   ChiTaRS; CRYBA2; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000163499; Expressed in islet of Langerhans and 93 other cell types or tissues.
DR   ExpressionAtlas; C9JDH2; baseline and differential.
DR   GO; GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.20.10; Crystallins; 1.
DR   InterPro; IPR001064; Beta/gamma_crystallin.
DR   InterPro; IPR011024; G_crystallin-like.
DR   PANTHER; PTHR11818:SF7; BETA-CRYSTALLIN A2; 1.
DR   PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR   Pfam; PF00030; Crystall; 1.
DR   PRINTS; PR01367; BGCRYSTALLIN.
DR   SMART; SM00247; XTALbg; 1.
DR   SUPFAM; SSF49695; gamma-Crystallin-like; 1.
DR   PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 1.
PE   1: Evidence at protein level;
KW   Eye lens protein {ECO:0000256|ARBA:ARBA00022613};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:C9JDH2,
KW   ECO:0007829|ProteomicsDB:C9JDH2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          53..99
FT                   /note="Beta/gamma crystallin 'Greek key'"
FT                   /evidence="ECO:0000259|PROSITE:PS50915"
FT   NON_TER         128
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000395120.1"
SQ   SEQUENCE   128 AA;  14361 MW;  27BDD8B1AF414B87 CRC64;
     MSSAPAPGPA PASLTLWDEE DFQGRRCRLL SDCANVCERG GLPRVRSVKV ENGVWVAFEY
     PDFQGQQFIL EKGDYPRWSA WSGSSSHNSN QLLSFRPVLC ANHNDSRVTL FEGDNFQGCK
     FDLVDDYP
//