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Protein
Submitted name:

Fos-related antigen 2

Gene

FOSL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. double-stranded DNA binding Source: Ensembl
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cellular response to hormone stimulus Source: Ensembl
  2. female pregnancy Source: Ensembl
  3. positive regulation of fibroblast proliferation Source: Ensembl
  4. regulation of transcription from RNA polymerase II promoter Source: InterPro
  5. response to cAMP Source: Ensembl
  6. response to corticosterone Source: Ensembl
  7. response to drug Source: Ensembl
  8. response to mechanical stimulus Source: Ensembl
  9. response to morphine Source: Ensembl
  10. response to progesterone Source: Ensembl
  11. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

SignaLinkiC9JCN8.

Names & Taxonomyi

Protein namesi
Submitted name:
Fos-related antigen 2Imported
Gene namesi
Name:FOSL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3798. FOSL2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiC9JCN8.
ExpressionAtlasiC9JCN8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JCN8.
SMRiC9JCN8. Positions 86-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains bZIP (basic-leucine zipper) domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF25. PTHR23351:SF25. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9JCN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSGSAFIP TINAITTSQD LQWMVQPTVI TSMSNPYPRS HPYSPLPGLA
60 70 80 90 100
SVPGHMALPR PGVIKTIGTT VGRRRRDEQL SPEEEEKRRI RRERNKLAAA
110 120 130 140 150
KCRNRRRELT EKLQAETEEL EEEKSGLQKE IAELQKEKEK LEFMLVAHGP
160 170 180 190 200
VCKISPEERR SPPAPGLQPM RSGGGSVGAV VVKQEPLEED SPSSSSAGLD

KA
Length:202
Mass (Da):22,254
Last modified:November 2, 2009 - v1
Checksum:i7D32120CEDC46E84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei202 – 2021Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104695 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000436647; ENSP00000396497; ENSG00000075426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104695 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliC9JCN8.
SMRiC9JCN8. Positions 86-148.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436647; ENSP00000396497; ENSG00000075426.

Organism-specific databases

HGNCiHGNC:3798. FOSL2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.

Enzyme and pathway databases

SignaLinkiC9JCN8.

Miscellaneous databases

ChiTaRSiFOSL2. human.
NextBioi35485989.

Gene expression databases

BgeeiC9JCN8.
ExpressionAtlasiC9JCN8. baseline and differential.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029814. Fra2.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF25. PTHR23351:SF25. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:ra3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:rs3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JCN8_HUMAN
AccessioniPrimary (citable) accession number: C9JCN8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2009
Last sequence update: November 2, 2009
Last modified: March 31, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.