ID   C9JC67_HUMAN            Unreviewed;       165 AA.
AC   C9JC67;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 2.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSP00000396582.2};
DE   Flags: Fragment;
GN   Name=AFF3 {ECO:0000313|Ensembl:ENSP00000396582.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396582.2, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000396582.2, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000396582.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC010736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC133108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9JC67; -.
DR   SMR; C9JC67; -.
DR   MassIVE; C9JC67; -.
DR   PeptideAtlas; C9JC67; -.
DR   ProteomicsDB; 9551; -.
DR   Antibodypedia; 32831; 66 antibodies from 17 providers.
DR   Ensembl; ENST00000423966.6; ENSP00000396582.2; ENSG00000144218.21.
DR   UCSC; uc061mhs.1; human.
DR   HGNC; HGNC:6473; AFF3.
DR   VEuPathDB; HostDB:ENSG00000144218; -.
DR   GeneTree; ENSGT00950000182974; -.
DR   OMA; NSHRDCK; -.
DR   ChiTaRS; AFF3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144218; Expressed in cortical plate and 172 other cell types or tissues.
DR   ExpressionAtlas; C9JC67; baseline and differential.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   Gene3D; 6.10.250.2670; -; 1.
DR   InterPro; IPR007797; AF4/FMR2.
DR   PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR   Pfam; PF05110; AF-4; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:C9JC67,
KW   ECO:0007829|PeptideAtlas:C9JC67};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          45..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          141..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         165
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000396582.2"
SQ   SEQUENCE   165 AA;  18803 MW;  40F641812FC65274 CRC64;
     MDSFDLALLQ EWDLESLWGE DILNQRNDSL VVEFQSSASR CRSVYEPDRN ALRRKERERR
     NQETQQDDGT FNSSYSLFSE PYKTNKGDEL SNRIQNTLGN YDEMKDFLTD RSNQSHLVGV
     PKPGVPQTPV NKIDEHFVAD SRAQNQPSSI CSTTTSTPAA VPVQQ
//