ID C9JBF0_HUMAN Unreviewed; 521 AA. AC C9JBF0; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 27-MAR-2024, entry version 77. DE SubName: Full=Leucine rich repeat kinase 2 {ECO:0000313|Ensembl:ENSP00000398726.1}; DE Flags: Fragment; GN Name=LRRK2 {ECO:0000313|Ensembl:ENSP00000398726.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398726.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000398726.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16541075; DOI=10.1038/nature04569; RG Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team; RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., RA Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., RA Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., RA Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., RA Gibbs R.A., null.; RT "The finished DNA sequence of human chromosome 12."; RL Nature 440:346-351(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000398726.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC079630; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC084290; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC107023; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; C9JBF0; -. DR SMR; C9JBF0; -. DR MassIVE; C9JBF0; -. DR PeptideAtlas; C9JBF0; -. DR ProteomicsDB; 9456; -. DR Antibodypedia; 2109; 1008 antibodies from 48 providers. DR Ensembl; ENST00000416796.5; ENSP00000398726.1; ENSG00000188906.17. DR UCSC; uc058msh.1; human. DR HGNC; HGNC:18618; LRRK2. DR VEuPathDB; HostDB:ENSG00000188906; -. DR GeneTree; ENSGT00940000158267; -. DR HOGENOM; CLU_523344_0_0_1; -. DR ChiTaRS; LRRK2; human. DR Proteomes; UP000005640; Chromosome 12. DR Bgee; ENSG00000188906; Expressed in buccal mucosa cell and 154 other cell types or tissues. DR ExpressionAtlas; C9JBF0; baseline and differential. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR PANTHER; PTHR22895:SF9; PROTEIN AARDVARK; 1. DR PANTHER; PTHR22895; UNCHARACTERIZED; 1. DR SUPFAM; SSF48371; ARM repeat; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|MaxQB:C9JBF0, KW ECO:0007829|PeptideAtlas:C9JBF0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT NON_TER 521 FT /evidence="ECO:0000313|Ensembl:ENSP00000398726.1" SQ SEQUENCE 521 AA; 58158 MW; 2BB711990877908F CRC64; MRVASVQQVG WSLLCKLIEV CPGTMQSLMG PQDVGNDWEV LGVHQLILKM LTVHNASVNL SVIGLKTLDL LLTSGKITLL ILDEESDIFM LIFDAMHSFP ANDEVQKLGC KALHVLFERG NNVEVLMSGN VRCYNIVVEA MKAFPMSERI QEVSCCLLHR LTLGNFFNIL VLNEVHEFVV KAVQQYPENA ALQISALSCL ALLRSFPGIC ECIVNSLRTK CNTSLDIMAA VVPKILTVMK RHETSLPVQL EALRAILHFI VPGMPEESRE DTEFHHKLNM VKKQCFKNDI HKLVLAALNR FIGNPGIQKC GLKVISSIVH FPDALEMLSL EGAMDSVLHT LQMYPDDQEI QCLGLSLIGY LITKKNVFIG TGHLLAKILV SSLYRFKDVA EIQTKGFQTI LAILKLSASF SKLLVHHSFD LVIFHQMSSN IMEQKDQQFL NLCCKCFAKV AMDDYLKNVM LERACDQNNS IMVECLLLLG ADANQAKEGS SLICQVCEKE SSPKLVELLL NSGSREQDVR K //