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Protein
Submitted name:

Leucine-rich repeat serine/threonine-protein kinase 2

Gene

LRRK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine-rich repeat serine/threonine-protein kinase 2Imported
Gene namesi
Name:LRRK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18618. LRRK2.

PTM / Processingi

Proteomic databases

PRIDEiC9JBF0.

Expressioni

Gene expression databases

BgeeiC9JBF0.
ExpressionAtlasiC9JBF0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JBF0.
SMRiC9JBF0. Positions 452-515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063477.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JBF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVASVQQVG WSLLCKLIEV CPGTMQSLMG PQDVGNDWEV LGVHQLILKM
60 70 80 90 100
LTVHNASVNL SVIGLKTLDL LLTSGKITLL ILDEESDIFM LIFDAMHSFP
110 120 130 140 150
ANDEVQKLGC KALHVLFERG NNVEVLMSGN VRCYNIVVEA MKAFPMSERI
160 170 180 190 200
QEVSCCLLHR LTLGNFFNIL VLNEVHEFVV KAVQQYPENA ALQISALSCL
210 220 230 240 250
ALLRSFPGIC ECIVNSLRTK CNTSLDIMAA VVPKILTVMK RHETSLPVQL
260 270 280 290 300
EALRAILHFI VPGMPEESRE DTEFHHKLNM VKKQCFKNDI HKLVLAALNR
310 320 330 340 350
FIGNPGIQKC GLKVISSIVH FPDALEMLSL EGAMDSVLHT LQMYPDDQEI
360 370 380 390 400
QCLGLSLIGY LITKKNVFIG TGHLLAKILV SSLYRFKDVA EIQTKGFQTI
410 420 430 440 450
LAILKLSASF SKLLVHHSFD LVIFHQMSSN IMEQKDQQFL NLCCKCFAKV
460 470 480 490 500
AMDDYLKNVM LERACDQNNS IMVECLLLLG ADANQAKEGS SLICQVCEKE
510 520
SSPKLVELLL NSGSREQDVR K
Length:521
Mass (Da):58,158
Last modified:November 2, 2009 - v1
Checksum:i2BB711990877908F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei521 – 5211Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079630 Genomic DNA. No translation available.
AC084290 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000416796; ENSP00000398726; ENSG00000188906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079630 Genomic DNA. No translation available.
AC084290 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliC9JBF0.
SMRiC9JBF0. Positions 452-515.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC9JBF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416796; ENSP00000398726; ENSG00000188906.

Organism-specific databases

HGNCiHGNC:18618. LRRK2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063477.

Miscellaneous databases

ChiTaRSiLRRK2. human.
NextBioi35485844.

Gene expression databases

BgeeiC9JBF0.
ExpressionAtlasiC9JBF0. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR020683. Ankyrin_rpt-contain_dom.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9JBF0_HUMAN
AccessioniPrimary (citable) accession number: C9JBF0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2009
Last sequence update: November 2, 2009
Last modified: March 3, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationPeptideAtlas annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.