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UniProtKB - C9JBF0 (C9JBF0_HUMAN)

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Protein
Submitted name:

Leucine-rich repeat serine/threonine-protein kinase 2

Gene

LRRK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine-rich repeat serine/threonine-protein kinase 2Imported
Gene namesi
Name:LRRK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18618. LRRK2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188906.

PTM / Processingi

Proteomic databases

PeptideAtlasiC9JBF0.
PRIDEiC9JBF0.

Expressioni

Gene expression databases

BgeeiENSG00000188906.
ExpressionAtlasiC9JBF0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9JBF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063477.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JBF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVASVQQVG WSLLCKLIEV CPGTMQSLMG PQDVGNDWEV LGVHQLILKM 
        60         70         80         90        100
LTVHNASVNL SVIGLKTLDL LLTSGKITLL ILDEESDIFM LIFDAMHSFP 
       110        120        130        140        150
ANDEVQKLGC KALHVLFERG NNVEVLMSGN VRCYNIVVEA MKAFPMSERI 
       160        170        180        190        200
QEVSCCLLHR LTLGNFFNIL VLNEVHEFVV KAVQQYPENA ALQISALSCL 
       210        220        230        240        250
ALLRSFPGIC ECIVNSLRTK CNTSLDIMAA VVPKILTVMK RHETSLPVQL 
       260        270        280        290        300
EALRAILHFI VPGMPEESRE DTEFHHKLNM VKKQCFKNDI HKLVLAALNR 
       310        320        330        340        350
FIGNPGIQKC GLKVISSIVH FPDALEMLSL EGAMDSVLHT LQMYPDDQEI 
       360        370        380        390        400
QCLGLSLIGY LITKKNVFIG TGHLLAKILV SSLYRFKDVA EIQTKGFQTI 
       410        420        430        440        450
LAILKLSASF SKLLVHHSFD LVIFHQMSSN IMEQKDQQFL NLCCKCFAKV 
       460        470        480        490        500
AMDDYLKNVM LERACDQNNS IMVECLLLLG ADANQAKEGS SLICQVCEKE 
       510        520 
SSPKLVELLL NSGSREQDVR K
Length:521
Mass (Da):58,158
Last modified:November 3, 2009 - v1
Checksum:i2BB711990877908F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei521Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079630 Genomic DNA. No translation available.
AC084290 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000416796; ENSP00000398726; ENSG00000188906.
UCSCiuc058msh.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079630 Genomic DNA. No translation available.
AC084290 Genomic DNA. No translation available.
AC107023 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliC9JBF0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9JBF0.
PRIDEiC9JBF0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000416796; ENSP00000398726; ENSG00000188906.
UCSCiuc058msh.1. human.

Organism-specific databases

HGNCiHGNC:18618. LRRK2.
OpenTargetsiENSG00000188906.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063477.

Miscellaneous databases

ChiTaRSiLRRK2. human.

Gene expression databases

BgeeiENSG00000188906.
ExpressionAtlasiC9JBF0. baseline and differential.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC9JBF0_HUMAN
AccessioniPrimary (citable) accession number: C9JBF0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: June 7, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.