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Protein
Submitted name:

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 5Imported
Submitted name:
Interferon regulatory factor 5, isoform CRA_aImported
Gene namesi
Name:IRF5Imported
ORF Names:hCG_40517Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6120. IRF5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128604.

PTM / Processingi

Proteomic databases

PaxDbiC9JAU6.
PeptideAtlasiC9JAU6.

Expressioni

Gene expression databases

BgeeiENSG00000128604.
ExpressionAtlasiC9JAU6. baseline and differential.

Structurei

3D structure databases

SMRiC9JAU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 122IRF tryptophan pentad repeat DNA-bindingInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV. Eukaryota.
ENOG410XRXT. LUCA.
HOGENOMiHOG000203117.
OMAiMPPQPYK.
OrthoDBiEOG091G067P.

Family and domain databases

CDDicd00103. IRF. 1 hit.
Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR029838. IRF5.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF36. PTHR11949:SF36. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SM01243. IRF-3. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C9JAU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL
160 170 180 190 200
QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK WPPTLQPPTL RPPTLQPPTL
210 220 230 240 250
QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP ASLPPAGEQL
260 270 280 290 300
LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE
310 320 330 340 350
QVELFGPISL EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL
360 370 380 390 400
YAIRLCQCKV FWSGPCASAH DSCPNPIQRE VKTKLFSLEH FLNELILFQK
410 420 430 440 450
GQTNTPPPFE IFFCFGEEWP DRKPREKKLI TVQVVPVAAR LLLEMFSGEL
460 470 480 490 500
SWSADSIRLQ ISNPDLKDRM VEQFKELHHI WQSQQRLQPV AQAPPGAGLG
510
VGQGPWPMHP AGMQ
Length:514
Mass (Da):57,770
Last modified:June 7, 2017 - v9
Checksum:iD554D121D9E35893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025594 Genomic DNA. No translation available.
KF459647 Genomic DNA. No translation available.
CH471070 Genomic DNA. Translation: EAW83706.1.
RefSeqiNP_001092099.1. NM_001098629.2.
NP_001334857.1. NM_001347928.1.
XP_005250374.1. XM_005250317.3.
XP_006716037.1. XM_006715974.2.
XP_011514460.1. XM_011516158.2.
XP_011514461.1. XM_011516159.2.
XP_011514462.1. XM_011516160.1.
UniGeneiHs.521181.

Genome annotation databases

EnsembliENST00000489702; ENSP00000418037; ENSG00000128604.
GeneIDi3663.
UCSCiuc064hwe.1. human.

Similar proteinsi

Entry informationi

Entry nameiC9JAU6_HUMAN
AccessioniPrimary (citable) accession number: C9JAU6
Secondary accession number(s): A0A024R763
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 7, 2017
Last modified: August 30, 2017
This is version 65 of the entry and version 9 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported