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Protein
Submitted name:

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 5Imported
Gene namesi
Name:IRF5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:6120. IRF5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128604.

PTM / Processingi

Proteomic databases

PaxDbiC9JAU6.
PeptideAtlasiC9JAU6.

Expressioni

Gene expression databases

BgeeiENSG00000128604.
ExpressionAtlasiC9JAU6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349770.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 122IRF tryptophan pentad repeat DNA-bindingInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV. Eukaryota.
ENOG410XRXT. LUCA.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000203117.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR029838. IRF5.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF36. PTHR11949:SF36. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

C9JAU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEV

S
Length:151
Mass (Da):17,150
Last modified:October 5, 2016 - v8
Checksum:i203F1787B1A1E4F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei151Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025594 Genomic DNA. No translation available.
KF459647 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000489702; ENSP00000418037; ENSG00000128604.
UCSCiuc064hwe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025594 Genomic DNA. No translation available.
KF459647 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349770.

Proteomic databases

PaxDbiC9JAU6.
PeptideAtlasiC9JAU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000489702; ENSP00000418037; ENSG00000128604.
UCSCiuc064hwe.1. human.

Organism-specific databases

HGNCiHGNC:6120. IRF5.
OpenTargetsiENSG00000128604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCV. Eukaryota.
ENOG410XRXT. LUCA.
GeneTreeiENSGT00760000119093.
HOGENOMiHOG000203117.

Gene expression databases

BgeeiENSG00000128604.
ExpressionAtlasiC9JAU6. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR019817. Interferon_reg_fac_CS.
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR029838. IRF5.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PTHR11949:SF36. PTHR11949:SF36. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PRINTSiPR00267. INTFRNREGFCT.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00601. IRF_1. 1 hit.
PS51507. IRF_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC9JAU6_HUMAN
AccessioniPrimary (citable) accession number: C9JAU6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: April 12, 2017
This is version 61 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.