Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Interferon regulatory factor 5

Gene

IRF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon regulatory factor 5Imported
Submitted name:
Interferon regulatory factor 5, isoform CRA_aImported
Gene namesi
Name:IRF5Imported
ORF Names:hCG_40517Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000128604.18
HGNCiHGNC:6120 IRF5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128604

PTM / Processingi

Proteomic databases

PRIDEiC9JAU6

Expressioni

Gene expression databases

BgeeiENSG00000128604
ExpressionAtlasiC9JAU6 baseline and differential

Structurei

3D structure databases

SMRiC9JAU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 122IRF tryptophan pentad repeatInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFCV Eukaryota
ENOG410XRXT LUCA
HOGENOMiHOG000203117
OMAiMPPQPYK
OrthoDBiEOG091G067P

Family and domain databases

CDDicd00103 IRF, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.200.10, 1 hit
InterProiView protein in InterPro
IPR019817 Interferon_reg_fac_CS
IPR001346 Interferon_reg_fact_DNA-bd_dom
IPR019471 Interferon_reg_factor-3
IPR029838 IRF5
IPR017855 SMAD-like_dom_sf
IPR008984 SMAD_FHA_dom_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11949 PTHR11949, 1 hit
PTHR11949:SF10 PTHR11949:SF10, 1 hit
PfamiView protein in Pfam
PF00605 IRF, 1 hit
PF10401 IRF-3, 1 hit
PRINTSiPR00267 INTFRNREGFCT
SMARTiView protein in SMART
SM00348 IRF, 1 hit
SM01243 IRF-3, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS00601 IRF_1, 1 hit
PS51507 IRF_2, 1 hit

Sequencei

Sequence statusi: Complete.

C9JAU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA
60 70 80 90 100
TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF
110 120 130 140 150
RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL
160 170 180 190 200
QRMLPSLSLT DAVQSGPHMT PYSLLKEDVK WPPTLQPPTL RPPTLQPPTL
210 220 230 240 250
QPPVVLGPPA PDPSPLAPPP GNPAGFRELL SEVLEPGPLP ASLPPAGEQL
260 270 280 290 300
LPDLLISPHM LPLTDLEIKF QYRGRPPRAL TISNPHGCRL FYSQLEATQE
310 320 330 340 350
QVELFGPISL EQVRFPSPED IPSDKQRFYT NQLLDVLDRG LILQLQGQDL
360 370 380 390 400
YAIRLCQCKV FWSGPCASAH DSCPNPIQRE VKTKLFSLEH FLNELILFQK
410 420 430 440 450
GQTNTPPPFE IFFCFGEEWP DRKPREKKLI TVQVVPVAAR LLLEMFSGEL
460 470 480 490 500
SWSADSIRLQ ISNPDLKDRM VEQFKELHHI WQSQQRLQPV AQAPPGAGLG
510
VGQGPWPMHP AGMQ
Length:514
Mass (Da):57,770
Last modified:June 7, 2017 - v9
Checksum:iD554D121D9E35893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025594 Genomic DNA No translation available.
KF459647 Genomic DNA No translation available.
CH471070 Genomic DNA Translation: EAW83706.1
RefSeqiNP_001092099.1, NM_001098629.2
NP_001334857.1, NM_001347928.1
XP_005250374.1, XM_005250317.3
XP_006716037.1, XM_006715974.2
XP_011514460.1, XM_011516158.2
XP_011514461.1, XM_011516159.2
XP_011514462.1, XM_011516160.1
UniGeneiHs.521181

Genome annotation databases

EnsembliENST00000489702; ENSP00000418037; ENSG00000128604
GeneIDi3663
UCSCiuc064hwe.1 human

Similar proteinsi

Entry informationi

Entry nameiC9JAU6_HUMAN
AccessioniPrimary (citable) accession number: C9JAU6
Secondary accession number(s): A0A024R763
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 7, 2017
Last modified: May 23, 2018
This is version 73 of the entry and version 9 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health