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Protein
Submitted name:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Gene

PIK3CA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformImported
Gene namesi
Name:PIK3CAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:8975. PIK3CA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000121879.

PTM / Processingi

Proteomic databases

MaxQBiC9JAM9.
PaxDbiC9JAM9.
PeptideAtlasiC9JAM9.

Expressioni

Gene expression databases

BgeeiENSG00000121879.
ExpressionAtlasiC9JAM9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000263967.

Structurei

3D structure databases

ProteinModelPortaliC9JAM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 105PI3K-ABDInterPro annotationAdd BLAST90

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000200034.

Family and domain databases

InterProiIPR003113. PI3K_adapt-bd_dom.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF02192. PI3K_p85B. 1 hit.
[Graphical view]
SMARTiSM00143. PI3K_p85B. 1 hit.
[Graphical view]
PROSITEiPS51544. PI3K_ABD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9JAM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRPSSGEL WGIHLMPPRI LVECLLPNGM IVTLECLREA TLITIKHELF
60 70 80 90 100
KEARKYPLHQ LLQDESSYIF VSVTQEAERE EFFDETRRLC DLRLFQPFLK
110
VIEPVGNREE KILNREIG
Length:118
Mass (Da):13,847
Last modified:November 3, 2009 - v1
Checksum:i34775C6319A88543
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei118Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC076966 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000468036; ENSP00000417479; ENSG00000121879.
UCSCiuc062qdy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC076966 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliC9JAM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000263967.

Proteomic databases

MaxQBiC9JAM9.
PaxDbiC9JAM9.
PeptideAtlasiC9JAM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000468036; ENSP00000417479; ENSG00000121879.
UCSCiuc062qdy.1. human.

Organism-specific databases

HGNCiHGNC:8975. PIK3CA.
OpenTargetsiENSG00000121879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0904. Eukaryota.
COG5032. LUCA.
GeneTreeiENSGT00760000119110.
HOGENOMiHOG000200034.

Miscellaneous databases

ChiTaRSiPIK3CA. human.

Gene expression databases

BgeeiENSG00000121879.
ExpressionAtlasiC9JAM9. baseline and differential.

Family and domain databases

InterProiIPR003113. PI3K_adapt-bd_dom.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF02192. PI3K_p85B. 1 hit.
[Graphical view]
SMARTiSM00143. PI3K_p85B. 1 hit.
[Graphical view]
PROSITEiPS51544. PI3K_ABD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9JAM9_HUMAN
AccessioniPrimary (citable) accession number: C9JAM9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.