ID   C9J9W1_HUMAN            Unreviewed;       215 AA.
AC   C9J9W1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Interleukin 1 receptor accessory protein {ECO:0000313|Ensembl:ENSP00000391899.1};
GN   Name=IL1RAP {ECO:0000313|Ensembl:ENSP00000391899.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000391899.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000391899.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000391899.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC008249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9J9W1; -.
DR   SMR; C9J9W1; -.
DR   MassIVE; C9J9W1; -.
DR   MaxQB; C9J9W1; -.
DR   PaxDb; 9606-ENSP00000314807; -.
DR   PeptideAtlas; C9J9W1; -.
DR   ProteomicsDB; 9235; -.
DR   Antibodypedia; 19361; 462 antibodies from 38 providers.
DR   Ensembl; ENST00000434491.5; ENSP00000391899.1; ENSG00000196083.11.
DR   UCSC; uc062rjx.1; human.
DR   HGNC; HGNC:5995; IL1RAP.
DR   VEuPathDB; HostDB:ENSG00000196083; -.
DR   eggNOG; ENOG502QRDG; Eukaryota.
DR   GeneTree; ENSGT01090000260076; -.
DR   HOGENOM; CLU_1282865_0_0_1; -.
DR   ChiTaRS; IL1RAP; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000196083; Expressed in right lobe of liver and 151 other cell types or tissues.
DR   ExpressionAtlas; C9J9W1; baseline and differential.
DR   GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR   CDD; cd20993; Ig2_IL-1RAP_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR   PANTHER; PTHR11890:SF20; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; 1.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   PRINTS; PR01536; INTRLKN1R12F.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Proteomics identification {ECO:0007829|MaxQB:C9J9W1,
KW   ECO:0007829|PeptideAtlas:C9J9W1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1..89
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          101..207
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   215 AA;  24329 MW;  439EAE1EACD0E2DB CRC64;
     MKLPVHKLYI EYGIQRITCP NVDGYFPSSV KPTITWYMGC YKIQNFNNVI PEGMNLSFLI
     ALISNNGNYT CVVTYPENGR TFHLTRTLTV KVVGSPKNAV PPVIHSPNDH VVYEKEPGEE
     LLIPCTVYFS FLMDSRNEVW WTIDGKKPDD ITIDVTINES ISHSRTEDET RTQILSIKKV
     TSEDLKRSYV CHARSAKGEV AKAAKVKQKG NRCGQ
//