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C9J9N2

- C9J9N2_HUMAN

UniProt

C9J9N2 - C9J9N2_HUMAN

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Protein
Submitted name: Endothelial PAS domain-containing protein 1
Gene
EPAS1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. signal transducer activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. blood vessel remodeling Source: Ensembl
  3. cell maturation Source: Ensembl
  4. embryonic placenta development Source: Ensembl
  5. erythrocyte differentiation Source: Ensembl
  6. lung development Source: Ensembl
  7. mitochondrion organization Source: Ensembl
  8. myoblast fate commitment Source: Ensembl
  9. norepinephrine metabolic process Source: Ensembl
  10. regulation of heart rate Source: Ensembl
  11. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
  12. surfactant homeostasis Source: Ensembl
  13. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Endothelial PAS domain-containing protein 1Imported
Gene namesi
Name:EPAS1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:3374. EPAS1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiC9J9N2.
BgeeiC9J9N2.

Structurei

3D structure databases

ProteinModelPortaliC9J9N2.
SMRiC9J9N2. Positions 15-70, 92-149.

Family & Domainsi

Sequence similaritiesi

Contains bHLH (basic helix-loop-helix) domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000236298.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9J9N2-1 [UniParc]FASTAAdd to Basket

« Hide

MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH    50
LDKASIMRLA ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA 100
VVTQDGDMIF LSENISKFMG LTQVELTGHS IFDFTHPCDH EEIRENLSLK 150
NGSGFGKKSK DMSTERDFFM RMKCTVTNRG RTVNLKSATW KVLHCTGQVK 200
VYNNCPPHNS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD SKTFLSRHSM 250
DMKFTYCDD 259
Length:259
Mass (Da):29,638
Last modified:November 3, 2009 - v1
Checksum:i45ABAF27709B1CEF
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei259 – 2591Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC016696 Genomic DNA. No translation available.
AC016912 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000449347; ENSP00000406137; ENSG00000116016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC016696 Genomic DNA. No translation available.
AC016912 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali C9J9N2.
SMRi C9J9N2. Positions 15-70, 92-149.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000449347 ; ENSP00000406137 ; ENSG00000116016 .

Organism-specific databases

HGNCi HGNC:3374. EPAS1.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000236298.

Miscellaneous databases

ChiTaRSi EPAS1. human.
NextBioi 35485618.

Gene expression databases

ArrayExpressi C9J9N2.
Bgeei C9J9N2.

Family and domain databases

InterProi IPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view ]
Pfami PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00785. NCTRNSLOCATR.
SMARTi SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9J9N2_HUMAN
AccessioniPrimary (citable) accession number: C9J9N2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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