RAB7A

Functionⁱ

GO - Molecular functionⁱ

GTP binding Source: InterPro

GO - Biological processⁱ

small GTPase mediated signal transduction Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Ras-related protein Rab-7aImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000417668
Gene namesⁱ	Name:RAB7AImported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000417668
Organismⁱ	Homo sapiens (Human)Imported Automatic assertion inferred from database entriesⁱ Ensembl:ENSP00000417668 Proteomes:UP000005640
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

HGNCⁱ

HGNC:9788. RAB7A.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

PTM / Processingⁱ

Proteomic databases

PeptideAtlasⁱ	C9J8S3.
PRIDEⁱ	C9J8S3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000075785.
ExpressionAtlasⁱ	C9J8S3. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	C9J8S3.
SMRⁱ	C9J8S3. Positions 7-143.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119125.
HOGENOMⁱ	HOG000233968.

Family and domain databases

Gene3Dⁱ	3.40.50.300. 2 hits.
InterProⁱ	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfamⁱ	PF00071. Ras. 1 hit. [Graphical view]
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

C9J8S3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTSRKKVLLK VIILGDSGVG KTSLMNQYVN KKFSNQYKAT IGADFLTKEV 
        60         70         80         90        100
MVDDRLVTMQ IWDTAGQERF QSLGVAFYRG ADCCVLVATK RAQAWCYSKN 
       110        120        130        140        150
NIPYFETSAK EAINVEQAFQ TIARNALKQE TEVELYNEFP EPIKLDKNDR 
       160
AKASAESCSC

Length:160

Mass (Da):18,027

Last modified:November 3, 2009 - v1

Checksum:ⁱ8D09DD9DDD45E6F7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC023598 Genomic DNA. No translation available. AC079945 Genomic DNA. No translation available. AC117508 Genomic DNA. No translation available. AC139617 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC023598 Genomic DNA. No translation available.
AC079945 Genomic DNA. No translation available.
AC117508 Genomic DNA. No translation available.
AC139617 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000482525; ENSP00000417668; ENSG00000075785.
UCSCⁱ	uc010hsv.2. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC023598 Genomic DNA. No translation available. AC079945 Genomic DNA. No translation available. AC117508 Genomic DNA. No translation available. AC139617 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC023598 Genomic DNA. No translation available.
AC079945 Genomic DNA. No translation available.
AC117508 Genomic DNA. No translation available.
AC139617 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	C9J8S3.
SMRⁱ	C9J8S3. Positions 7-143.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	C9J8S3.
PRIDEⁱ	C9J8S3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000482525; ENSP00000417668; ENSG00000075785.
UCSCⁱ	uc010hsv.2. human.

Organism-specific databases

HGNCⁱ	HGNC:9788. RAB7A.
GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000119125.
HOGENOMⁱ	HOG000233968.

Miscellaneous databases

ChiTaRSⁱ	RAB7A. human.

ChiTaRSⁱ

RAB7A. human.

Gene expression databases

Bgeeⁱ	ENSG00000075785.
ExpressionAtlasⁱ	C9J8S3. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.40.50.300. 2 hits.
InterProⁱ	IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfamⁱ	PF00071. Ras. 1 hit. [Graphical view]
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR00231. small_GTP. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

C9J8S3_HUMAN

Accessionⁱ

Primary (citable) accession number: C9J8S3

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C9J8S3 (C9J8S3_HUMAN)

UniProt

C9J8S3 - C9J8S3_HUMAN

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Ras-related protein Rab-7a

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ