ID   C9J847_HUMAN            Unreviewed;       114 AA.
AC   C9J847;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSP00000411383.1};
DE   Flags: Fragment;
GN   Name=AFF3 {ECO:0000313|Ensembl:ENSP00000411383.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000411383.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000411383.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000411383.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC010736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC073118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC092667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC104782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC133108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; C9J847; -.
DR   SMR; C9J847; -.
DR   MassIVE; C9J847; -.
DR   PeptideAtlas; C9J847; -.
DR   ProteomicsDB; 8994; -.
DR   Antibodypedia; 32831; 66 antibodies from 17 providers.
DR   Ensembl; ENST00000424600.5; ENSP00000411383.1; ENSG00000144218.21.
DR   UCSC; uc061mhu.1; human.
DR   HGNC; HGNC:6473; AFF3.
DR   VEuPathDB; HostDB:ENSG00000144218; -.
DR   GeneTree; ENSGT00950000182974; -.
DR   ChiTaRS; AFF3; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000144218; Expressed in cortical plate and 172 other cell types or tissues.
DR   ExpressionAtlas; C9J847; baseline and differential.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   Gene3D; 6.10.250.2670; -; 1.
DR   InterPro; IPR007797; AF4/FMR2.
DR   PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR   Pfam; PF05110; AF-4; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:C9J847,
KW   ECO:0007829|PeptideAtlas:C9J847};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          23..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         114
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000411383.1"
SQ   SEQUENCE   114 AA;  13270 MW;  B096B7E444A0F3A7 CRC64;
     MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY SLFSEPYKTN
     KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPGV PQTPVNKIDE HFVA
//