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Protein

Ras GTPase-activating protein 4B

Gene

RASA4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ca2+-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri675 – 711Btk-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 4B
Gene namesi
Name:RASA4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000170667.14
HGNCiHGNC:35202 RASA4B
neXtProtiNX_C9J798

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003953241 – 803Ras GTPase-activating protein 4BAdd BLAST803

Proteomic databases

MaxQBiC9J798
PaxDbiC9J798
PRIDEiC9J798

PTM databases

iPTMnetiC9J798
PhosphoSitePlusiC9J798

Expressioni

Gene expression databases

BgeeiENSG00000170667
ExpressionAtlasiC9J798 baseline and differential
GenevisibleiC9J798 HS

Organism-specific databases

HPAiHPA043010

Interactioni

Protein-protein interaction databases

BioGridi938526, 1 interactor
STRINGi9606.ENSP00000417895

Structurei

3D structure databases

ProteinModelPortaliC9J798
SMRiC9J798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini120 – 216C2 2PROSITE-ProRule annotationAdd BLAST97
Domaini302 – 512Ras-GAPPROSITE-ProRule annotationAdd BLAST211
Domaini566 – 673PHPROSITE-ProRule annotationAdd BLAST108

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri675 – 711Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000070144
InParanoidiC9J798
OMAiTCPAVIR
OrthoDBiEOG091G04T8
PhylomeDBiC9J798
TreeFamiTF105302

Family and domain databases

CDDicd13372 PH_CAPRI, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037777 RASA4_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

Sequencei

Sequence statusi: Complete.

C9J798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC
60 70 80 90 100
PFWGEEYQVH LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG
110 120 130 140 150
FSGWAHLTEV DPDEEVQGEI HLRLEVWPGA RACRLRCSVL EARDLAPKDR
160 170 180 190 200
NGTSDPFVRV RYKGRTRETS IVKKSCYPRW NETFEFELQE GAMEALCVEA
210 220 230 240 250
WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK SRRHDEGNLG
260 270 280 290 300
SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST
310 320 330 340 350
ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK
360 370 380 390 400
SVESFLKVAG MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH
410 420 430 440 450
RPQTEAEVLE QSAQTLRAHL GALLSALSRS VRACPAVVRA TFRQLFRRVR
460 470 480 490 500
ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM SPKLFHLRER HADARTSRTL
510 520 530 540 550
LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVHQGVAQLK DFITKLVDIE
560 570 580 590 600
EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA
610 620 630 640 650
LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT
660 670 680 690 700
AYLQCKCVNE LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK
710 720 730 740 750
TGQGCDKTRS RVTLQEWNDP LDHDLEAQLI YRHLLGVEAM LWERHRELSG
760 770 780 790 800
GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR EAHSSSPAGS PPSEPNCLLE

LQT
Length:803
Mass (Da):90,406
Last modified:July 13, 2010 - v2
Checksum:i613631916A008BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093668 Genomic DNA No translation available.
RefSeqiXP_005250141.1, XM_005250084.2
UniGeneiHs.530089

Genome annotation databases

EnsembliENST00000465829; ENSP00000417895; ENSG00000170667
GeneIDi100271927
UCSCiuc003uzt.3 human

Similar proteinsi

Entry informationi

Entry nameiRAS4B_HUMAN
AccessioniPrimary (citable) accession number: C9J798
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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