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Protein

Ras GTPase-activating protein 4B

Gene

RASA4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ca2+-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri675 – 71137Btk-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 4B
Gene namesi
Name:RASA4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:35202. RASA4B.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Ras GTPase-activating protein 4BPRO_0000395324Add
BLAST

Proteomic databases

EPDiC9J798.
MaxQBiC9J798.
PaxDbiC9J798.
PRIDEiC9J798.

PTM databases

iPTMnetiC9J798.
PhosphoSiteiC9J798.

Expressioni

Gene expression databases

BgeeiC9J798.
ExpressionAtlasiC9J798. baseline and differential.
GenevisibleiC9J798. HS.

Organism-specific databases

HPAiHPA043010.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417895.

Structurei

3D structure databases

ProteinModelPortaliC9J798.
SMRiC9J798. Positions 5-562, 573-707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini120 – 21697C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini302 – 512211Ras-GAPPROSITE-ProRule annotationAdd
BLAST
Domaini566 – 673108PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri675 – 71137Btk-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000070144.
InParanoidiC9J798.
OMAiRTCPAVI.
OrthoDBiEOG7J17Z6.
PhylomeDBiC9J798.
TreeFamiTF105302.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
4.10.1130.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRSSLYIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLC
60 70 80 90 100
PFWGEEYQVH LPPTFHAVAF YVMDEDALSR DDVIGKVCLT RDTIASHPKG
110 120 130 140 150
FSGWAHLTEV DPDEEVQGEI HLRLEVWPGA RACRLRCSVL EARDLAPKDR
160 170 180 190 200
NGTSDPFVRV RYKGRTRETS IVKKSCYPRW NETFEFELQE GAMEALCVEA
210 220 230 240 250
WDWDLVSRND FLGKVVIDVQ RLRVVQQEEG WFRLQPDQSK SRRHDEGNLG
260 270 280 290 300
SLQLEVRLRD ETVLPSSYYQ PLVHLLCHEV KLGMQGPGQL IPLIEETTST
310 320 330 340 350
ECRQDVATNL LKLFLGQGLA KDFLDLLFQL ELSRTSETNT LFRSNSLASK
360 370 380 390 400
SVESFLKVAG MQYLHGVLGP IINKVFEEKK YVELDPSKVE VKDVGCSGLH
410 420 430 440 450
RPQTEAEVLE QSAQTLRAHL GALLSALSRS VRACPAVVRA TFRQLFRRVR
460 470 480 490 500
ERFPGAQHEN VPFIAVTSFL CLRFFSPAIM SPKLFHLRER HADARTSRTL
510 520 530 540 550
LLLAKAVQNV GNMDTPASRA KEAWMEPLQP TVHQGVAQLK DFITKLVDIE
560 570 580 590 600
EKDELDLQRT LSLQAPPVKE GPLFIHRTKG KGPLMSSSFK KLYFSLTTEA
610 620 630 640 650
LSFAKTPSSK KSALIKLANI RAAEKVEEKS FGGSHVMQVI YTDDAGRPQT
660 670 680 690 700
AYLQCKCVNE LNQWLSALRK VSINNTGLLG SYHPGVFRGD KWSCCHQKEK
710 720 730 740 750
TGQGCDKTRS RVTLQEWNDP LDHDLEAQLI YRHLLGVEAM LWERHRELSG
760 770 780 790 800
GAEAGTVPTS PGKVPEDSLA RLLRVLQDLR EAHSSSPAGS PPSEPNCLLE

LQT
Length:803
Mass (Da):90,406
Last modified:July 13, 2010 - v2
Checksum:i613631916A008BB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093668 Genomic DNA. No translation available.
RefSeqiXP_005250141.1. XM_005250084.1.
UniGeneiHs.530089.

Genome annotation databases

EnsembliENST00000465829; ENSP00000417895; ENSG00000170667.
GeneIDi100271927.
UCSCiuc003uzt.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093668 Genomic DNA. No translation available.
RefSeqiXP_005250141.1. XM_005250084.1.
UniGeneiHs.530089.

3D structure databases

ProteinModelPortaliC9J798.
SMRiC9J798. Positions 5-562, 573-707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417895.

PTM databases

iPTMnetiC9J798.
PhosphoSiteiC9J798.

Proteomic databases

EPDiC9J798.
MaxQBiC9J798.
PaxDbiC9J798.
PRIDEiC9J798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000465829; ENSP00000417895; ENSG00000170667.
GeneIDi100271927.
UCSCiuc003uzt.3. human.

Organism-specific databases

CTDi100271927.
GeneCardsiRASA4B.
HGNCiHGNC:35202. RASA4B.
HPAiHPA043010.
neXtProtiNX_C9J798.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000070144.
InParanoidiC9J798.
OMAiRTCPAVI.
OrthoDBiEOG7J17Z6.
PhylomeDBiC9J798.
TreeFamiTF105302.

Miscellaneous databases

GenomeRNAii100271927.
PROiC9J798.

Gene expression databases

BgeeiC9J798.
ExpressionAtlasiC9J798. baseline and differential.
GenevisibleiC9J798. HS.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
4.10.1130.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRAS4B_HUMAN
AccessioniPrimary (citable) accession number: C9J798
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 8, 2016
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.