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Protein
Submitted name:

Zinc finger CCCH-type antiviral protein 1

Gene

ZC3HAV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger CCCH-type antiviral protein 1Imported
Gene namesi
Name:ZC3HAV1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23721. ZC3HAV1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiC9J6P4.
MaxQBiC9J6P4.
PaxDbiC9J6P4.
PeptideAtlasiC9J6P4.
PRIDEiC9J6P4.

Expressioni

Gene expression databases

BgeeiC9J6P4.
ExpressionAtlasiC9J6P4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiC9J6P4. 5 interactions.
STRINGi9606.ENSP00000242351.

Structurei

3D structure databases

ProteinModelPortaliC9J6P4.
SMRiC9J6P4. Positions 3-225, 848-1018.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 11338C3H1-typeInterPro annotationAdd
BLAST
Domaini173 – 19422C3H1-typeInterPro annotationAdd
BLAST
Domaini630 – 65627C3H1-typeInterPro annotationAdd
BLAST
Domaini716 – 80388WWEInterPro annotationAdd
BLAST
Domaini838 – 1024187PARP catalyticInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains PARP catalytic domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
OMAiNLCKYSH.
PhylomeDBiC9J6P4.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J6P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPEVCCFI TKILCAHGGR MALDALLQEI ALSEPQLCEV LQVAGPDRFV
60 70 80 90 100
VLETGGEAGI TRSVVATTRA RVCRRKYCQR PCDNLHLCKL NLLGRCNYSQ
110 120 130 140 150
SERNLCKYSH EVLSEENFKV LKNHELSGLN KEELAVLLLQ SDPFFMPEIC
160 170 180 190 200
KSYKGEGRQQ ICNQQPPCSR LHICDHFTRG NCRFPNCLRS HNLMDRKVLA
210 220 230 240 250
IMREHGLNPD VVQNIQDICN SKHMQKNPPG PRAPSSHRRN MAYRARSKSR
260 270 280 290 300
DRFFQGSQEF LASASASAER SCTPSPDQIS HRASLEDAPV DDLTRKFTYL
310 320 330 340 350
GSQDRARPPS GSSKATDLGG TSQAGTSQRF LENGSQEDLL HGNPGSTYLA
360 370 380 390 400
SNSTSAPNWK SLTSWTNDQG ARRKTVFSPT LPAARSSLGS LQTPEAVTTR
410 420 430 440 450
KGTGLLSSDY RIINGKSGTQ DIQPGPLFNN NADGVATDIT STRSLNYKST
460 470 480 490 500
SSGHREISSP RIQDAGPASR DVQATGRIAD DADPRVALVN GKYKGKTLWA
510 520 530 540 550
STFVHDIPNG SSQVVDKTTD VEKTGATGFG LTMAVKAEKD MLRTGSQSLR
560 570 580 590 600
NLVPTTPGES TAPAQVSTLP QSPAALSSSN RAAVWGAQGQ NCTQVPVSSA
610 620 630 640 650
SELTRKTTGS AQYSLSDVTS TTSSRVDDHD SEEICLDHLC KGCPLNGSCS
660 670 680 690 700
KVHFHLPYRW QMLIGKTWTD FEHMETIEKG YCNPGIHLCS VGSYTINFRV
710 720 730 740 750
MSCDSFPIRR LSTPSSVTKP ANSVFTTKWI WYWKNESGTW IQYGEEKDKR
760 770 780 790 800
KNSNVDSSYL ESLYQSCPRG VVPFQAGSRN YELSFQGMIQ TNIASKTQKD
810 820 830 840 850
VIRRPTFVPQ WYVQQMKRGP DHQPAKTSSV SLTATFRPQE DFCFLSSKKY
860 870 880 890 900
KLSEIHHLHP EYVRVSEHFK ASMKNFKIEK IKKIENSELL DKFTWKKSQM
910 920 930 940 950
KEEGKLLFYA TSRAYVESIC SNNFDSFLHE THENKYGKGI YFAKDAIYSH
960 970 980 990 1000
KNCPYDAKNV VMFVAQVLVG KFTEGNITYT SPPPQFDSCV DTRSNPSVFV
1010 1020
IFQKDQVYPQ YVIEYTEDKA CVIS
Length:1,024
Mass (Da):114,085
Last modified:November 3, 2009 - v1
Checksum:iFD15D0C32EA69B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018644 Genomic DNA. No translation available.
AC083868 Genomic DNA. No translation available.
RefSeqiXP_005250558.1. XM_005250501.1.
UniGeneiHs.133512.

Genome annotation databases

EnsembliENST00000464606; ENSP00000418385; ENSG00000105939.
GeneIDi56829.
UCSCiuc064ikv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018644 Genomic DNA. No translation available.
AC083868 Genomic DNA. No translation available.
RefSeqiXP_005250558.1. XM_005250501.1.
UniGeneiHs.133512.

3D structure databases

ProteinModelPortaliC9J6P4.
SMRiC9J6P4. Positions 3-225, 848-1018.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC9J6P4. 5 interactions.
STRINGi9606.ENSP00000242351.

Proteomic databases

EPDiC9J6P4.
MaxQBiC9J6P4.
PaxDbiC9J6P4.
PeptideAtlasiC9J6P4.
PRIDEiC9J6P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000464606; ENSP00000418385; ENSG00000105939.
GeneIDi56829.
UCSCiuc064ikv.1. human.

Organism-specific databases

CTDi56829.
HGNCiHGNC:23721. ZC3HAV1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
OMAiNLCKYSH.
PhylomeDBiC9J6P4.

Miscellaneous databases

ChiTaRSiZC3HAV1. human.
GenomeRNAii56829.

Gene expression databases

BgeeiC9J6P4.
ExpressionAtlasiC9J6P4. baseline and differential.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.D., Yates J.R.
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC9J6P4_HUMAN
AccessioniPrimary (citable) accession number: C9J6P4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.