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Protein
Submitted name:

Zinc finger CCCH-type antiviral protein 1

Gene

ZC3HAV1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 113C3H1-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri173 – 194C3H1-typePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri630 – 656C3H1-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger CCCH-type antiviral protein 1Imported
Gene namesi
Name:ZC3HAV1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23721. ZC3HAV1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105939.

PTM / Processingi

Proteomic databases

EPDiC9J6P4.
MaxQBiC9J6P4.
PaxDbiC9J6P4.
PeptideAtlasiC9J6P4.
PRIDEiC9J6P4.

Expressioni

Gene expression databases

BgeeiENSG00000105939.
ExpressionAtlasiC9J6P4. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiC9J6P4. 5 interactors.
STRINGi9606.ENSP00000242351.

Structurei

3D structure databases

ProteinModelPortaliC9J6P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 113C3H1-typeInterPro annotationAdd BLAST38
Domaini173 – 194C3H1-typeInterPro annotationAdd BLAST22
Domaini630 – 656C3H1-typeInterPro annotationAdd BLAST27
Domaini716 – 803WWEInterPro annotationAdd BLAST88
Domaini838 – 1024PARP catalyticInterPro annotationAdd BLAST187

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri76 – 113C3H1-typePROSITE-ProRule annotationAdd BLAST38
Zinc fingeri173 – 194C3H1-typePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri630 – 656C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
OMAiSHNLMDR.
OrthoDBiEOG091G14UY.
PhylomeDBiC9J6P4.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiView protein in InterPro
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
PfamiView protein in Pfam
PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PROSITEiView protein in PROSITE
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 3 hits.

Sequencei

Sequence statusi: Complete.

C9J6P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPEVCCFI TKILCAHGGR MALDALLQEI ALSEPQLCEV LQVAGPDRFV
60 70 80 90 100
VLETGGEAGI TRSVVATTRA RVCRRKYCQR PCDNLHLCKL NLLGRCNYSQ
110 120 130 140 150
SERNLCKYSH EVLSEENFKV LKNHELSGLN KEELAVLLLQ SDPFFMPEIC
160 170 180 190 200
KSYKGEGRQQ ICNQQPPCSR LHICDHFTRG NCRFPNCLRS HNLMDRKVLA
210 220 230 240 250
IMREHGLNPD VVQNIQDICN SKHMQKNPPG PRAPSSHRRN MAYRARSKSR
260 270 280 290 300
DRFFQGSQEF LASASASAER SCTPSPDQIS HRASLEDAPV DDLTRKFTYL
310 320 330 340 350
GSQDRARPPS GSSKATDLGG TSQAGTSQRF LENGSQEDLL HGNPGSTYLA
360 370 380 390 400
SNSTSAPNWK SLTSWTNDQG ARRKTVFSPT LPAARSSLGS LQTPEAVTTR
410 420 430 440 450
KGTGLLSSDY RIINGKSGTQ DIQPGPLFNN NADGVATDIT STRSLNYKST
460 470 480 490 500
SSGHREISSP RIQDAGPASR DVQATGRIAD DADPRVALVN GKYKGKTLWA
510 520 530 540 550
STFVHDIPNG SSQVVDKTTD VEKTGATGFG LTMAVKAEKD MLRTGSQSLR
560 570 580 590 600
NLVPTTPGES TAPAQVSTLP QSPAALSSSN RAAVWGAQGQ NCTQVPVSSA
610 620 630 640 650
SELTRKTTGS AQYSLSDVTS TTSSRVDDHD SEEICLDHLC KGCPLNGSCS
660 670 680 690 700
KVHFHLPYRW QMLIGKTWTD FEHMETIEKG YCNPGIHLCS VGSYTINFRV
710 720 730 740 750
MSCDSFPIRR LSTPSSVTKP ANSVFTTKWI WYWKNESGTW IQYGEEKDKR
760 770 780 790 800
KNSNVDSSYL ESLYQSCPRG VVPFQAGSRN YELSFQGMIQ TNIASKTQKD
810 820 830 840 850
VIRRPTFVPQ WYVQQMKRGP DHQPAKTSSV SLTATFRPQE DFCFLSSKKY
860 870 880 890 900
KLSEIHHLHP EYVRVSEHFK ASMKNFKIEK IKKIENSELL DKFTWKKSQM
910 920 930 940 950
KEEGKLLFYA TSRAYVESIC SNNFDSFLHE THENKYGKGI YFAKDAIYSH
960 970 980 990 1000
KNCPYDAKNV VMFVAQVLVG KFTEGNITYT SPPPQFDSCV DTRSNPSVFV
1010 1020
IFQKDQVYPQ YVIEYTEDKA CVIS
Length:1,024
Mass (Da):114,085
Last modified:November 3, 2009 - v1
Checksum:iFD15D0C32EA69B17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018644 Genomic DNA. No translation available.
AC083868 Genomic DNA. No translation available.
RefSeqiXP_005250558.1. XM_005250501.2.
UniGeneiHs.133512.

Genome annotation databases

EnsembliENST00000464606; ENSP00000418385; ENSG00000105939.
GeneIDi56829.
UCSCiuc064ikv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018644 Genomic DNA. No translation available.
AC083868 Genomic DNA. No translation available.
RefSeqiXP_005250558.1. XM_005250501.2.
UniGeneiHs.133512.

3D structure databases

ProteinModelPortaliC9J6P4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC9J6P4. 5 interactors.
STRINGi9606.ENSP00000242351.

Proteomic databases

EPDiC9J6P4.
MaxQBiC9J6P4.
PaxDbiC9J6P4.
PeptideAtlasiC9J6P4.
PRIDEiC9J6P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000464606; ENSP00000418385; ENSG00000105939.
GeneIDi56829.
UCSCiuc064ikv.1. human.

Organism-specific databases

CTDi56829.
HGNCiHGNC:23721. ZC3HAV1.
OpenTargetsiENSG00000105939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEI4. Eukaryota.
ENOG410ZFB8. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000236279.
OMAiSHNLMDR.
OrthoDBiEOG091G14UY.
PhylomeDBiC9J6P4.

Miscellaneous databases

ChiTaRSiZC3HAV1. human.
GenomeRNAii56829.

Gene expression databases

BgeeiENSG00000105939.
ExpressionAtlasiC9J6P4. baseline and differential.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiView protein in InterPro
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
PfamiView protein in Pfam
PF00644. PARP. 1 hit.
PF02825. WWE. 1 hit.
PROSITEiView protein in PROSITE
PS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiC9J6P4_HUMAN
AccessioniPrimary (citable) accession number: C9J6P4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: March 15, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.