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C9J6L5

- C9J6L5_HUMAN

UniProt

C9J6L5 - C9J6L5_HUMAN

Protein
Submitted name:

Cystic fibrosis transmembrane conductance regulator

Gene

CFTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. bicarbonate transmembrane transporter activity Source: Ensembl
    2. chloride transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to hormone stimulus Source: Ensembl
    3. cholesterol biosynthetic process Source: Ensembl
    4. cholesterol transport Source: Ensembl
    5. intracellular pH elevation Source: Ensembl
    6. iodide transport Source: Ensembl
    7. lung development Source: Ensembl
    8. membrane hyperpolarization Source: Ensembl
    9. positive regulation of vasodilation Source: Ensembl
    10. response to cytokine Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estrogen Source: Ensembl
    13. response to peptide hormone Source: Ensembl
    14. sperm capacitation Source: Ensembl
    15. transepithelial chloride transport Source: Ensembl
    16. vasodilation Source: Ensembl
    17. water transport Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cystic fibrosis transmembrane conductance regulatorImported
    Gene namesi
    Name:CFTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1884. CFTR.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl
    3. cytoplasmic vesicle membrane Source: Ensembl
    4. microvillus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiC9J6L5.
    BgeeiC9J6L5.

    Sequencei

    Sequence statusi: Fragment.

    C9J6L5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFYGIFLYLG EVTKAVQPLL LGRIIASYDP DNKEER                  36
    Length:36
    Mass (Da):4,161
    Last modified:May 14, 2014 - v2
    Checksum:i6E7DC6A0696F987C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei36 – 361Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC000061 Genomic DNA. No translation available.
    AC000111 Genomic DNA. No translation available.
    AC004240 Genomic DNA. No translation available.
    KF458571 Genomic DNA. No translation available.
    KF458577 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000446805; ENSP00000417012; ENSG00000001626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC000061 Genomic DNA. No translation available.
    AC000111 Genomic DNA. No translation available.
    AC004240 Genomic DNA. No translation available.
    KF458571 Genomic DNA. No translation available.
    KF458577 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000446805 ; ENSP00000417012 ; ENSG00000001626 .

    Organism-specific databases

    HGNCi HGNC:1884. CFTR.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35485228.

    Gene expression databases

    ArrayExpressi C9J6L5.
    Bgeei C9J6L5.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiC9J6L5_HUMAN
    AccessioniPrimary (citable) accession number: C9J6L5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3