C9J609 (C9J609_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Rho guanine nucleotide exchange factor 3 Ensembl ENSP00000417087

Gene names

Name:

ARHGEF3 Ensembl ENSP00000417087

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000417087

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	184 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000417087

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	184	1	Ensembl ENSP00000417087

Sequences

	Sequence		Length	Mass (Da)
	C9J609 [UniParc]. Last modified November 3, 2009. Version 1. Checksum: EA985C05CE09BBD3	FASTA	184	21,082
	10 20 30 40 50 60 MFPSPKAWNF RGRKRKQSTQ DEDAVSLCSL DISEPSNKRV KPLSRVTSLA NLIPPVKATP 70 80 90 100 110 120 LKRFSQTLQR SISFRSESRP DILAPRPWSR NAAPSSTKRR DSKLWSETFD VCVNQMLTSK 130 140 150 160 170 180 EIKRQEAIFE LSQGEEDLIE DLKLAKKAYH DPMLKLSIMT EQELNQIFGT LDSLIPLHEE LLSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC097358 Genomic DNA. No translation available. AC099327 Genomic DNA. No translation available. AC099559 Genomic DNA. No translation available. AC099781 Genomic DNA. No translation available.
IPI	IPI00792077.
3D structure databases
ProteinModelPortal	C9J609.
SMR	C9J609. Positions 115-184.
ModBase	Search...
Protein-protein interaction databases
STRING	C9J609.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000468727; ENSP00000417087; ENSG00000163947.
Organism-specific databases
HGNC	HGNC:683. ARHGEF3.
GenAtlas	Search...
Gene expression databases
ArrayExpress	C9J609.
Bgee	C9J609.
Family and domain databases
Gene3D	1.20.900.10. 1 hit.
InterPro	IPR000219. DH-domain. IPR015721. RhoGEF-like. [Graphical view]
PANTHER	PTHR22825. PTHR22825. 1 hit.
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS50010. DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ARHGEF3. human.
NextBio	35485137.

Entry information

Entry name

C9J609_HUMAN

Accession

Primary (citable) accession number: C9J609

Entry history

Integrated into UniProtKB/TrEMBL:	November 3, 2009
Last sequence update:	November 3, 2009
Last modified:	April 3, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.