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C9J5B0

- C9J5B0_HUMAN

UniProt

C9J5B0 - C9J5B0_HUMAN

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Protein
Submitted name:

Interleukin-6

Gene
IL6
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. aging Source: Ensembl
  2. bone remodeling Source: Ensembl
  3. branching involved in salivary gland morphogenesis Source: Ensembl
  4. cell growth Source: Ensembl
  5. cell redox homeostasis Source: Ensembl
  6. defense response to protozoan Source: Ensembl
  7. endocrine pancreas development Source: Ensembl
  8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  9. glucagon secretion Source: Ensembl
  10. immune response Source: InterPro
  11. interleukin-6-mediated signaling pathway Source: Ensembl
  12. muscle cell cellular homeostasis Source: Ensembl
  13. negative regulation of cell proliferation Source: Ensembl
  14. negative regulation of chemokine biosynthetic process Source: Ensembl
  15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  16. negative regulation of cytokine secretion Source: Ensembl
  17. negative regulation of gluconeogenesis Source: Ensembl
  18. negative regulation of hormone secretion Source: Ensembl
  19. negative regulation of muscle organ development Source: Ensembl
  20. negative regulation of neuron death Source: Ensembl
  21. negative regulation of protein kinase activity Source: Ensembl
  22. neutrophil apoptotic process Source: Ensembl
  23. positive regulation of DNA replication Source: Ensembl
  24. positive regulation of epithelial cell proliferation Source: Ensembl
  25. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  26. positive regulation of neuron differentiation Source: Ensembl
  27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  28. positive regulation of protein import into nucleus, translocation Source: Ensembl
  29. positive regulation of protein kinase B signaling Source: Ensembl
  30. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  31. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  32. positive regulation of transmission of nerve impulse Source: Ensembl
  33. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  34. regulation of cell shape Source: Ensembl
  35. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  36. response to amino acid Source: Ensembl
  37. response to antibiotic Source: Ensembl
  38. response to caffeine Source: Ensembl
  39. response to calcium ion Source: Ensembl
  40. response to cold Source: Ensembl
  41. response to drug Source: Ensembl
  42. response to electrical stimulus Source: Ensembl
  43. response to heat Source: Ensembl
  44. response to insulin Source: Ensembl
  45. response to lipopolysaccharide Source: Ensembl
  46. response to mechanical stimulus Source: Ensembl
  47. response to nutrient levels Source: Ensembl
  48. response to wounding Source: Ensembl
  49. T cell activation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-6Imported
Gene namesi
Name:IL6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:6018. IL6.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiC9J5B0.
BgeeiC9J5B0.

Structurei

3D structure databases

ProteinModelPortaliC9J5B0.
SMRiC9J5B0. Positions 47-152.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000236330.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9J5B0-1 [UniParc]FASTAAdd to Basket

« Hide

MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS    50
ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG 100
CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL 150
IQ 152
Length:152
Mass (Da):16,791
Last modified:November 3, 2009 - v1
Checksum:iEE1562147E15AF4F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei152 – 1521Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073072 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000426291; ENSP00000405150; ENSG00000136244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073072 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali C9J5B0.
SMRi C9J5B0. Positions 47-152.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000426291 ; ENSP00000405150 ; ENSG00000136244 .

Organism-specific databases

HGNCi HGNC:6018. IL6.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000236330.

Miscellaneous databases

ChiTaRSi IL6. human.
NextBioi 35485040.

Gene expression databases

ArrayExpressi C9J5B0.
Bgeei C9J5B0.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view ]
PANTHERi PTHR11457. PTHR11457. 1 hit.
Pfami PF00489. IL6. 1 hit.
[Graphical view ]
PRINTSi PR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTi SM00126. IL6. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9J5B0_HUMAN
AccessioniPrimary (citable) accession number: C9J5B0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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