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C9J5B0

- C9J5B0_HUMAN

UniProt

C9J5B0 - C9J5B0_HUMAN

Protein
Submitted name:

Interleukin-6

Gene

IL6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Biological processi

    1. aging Source: Ensembl
    2. bone remodeling Source: Ensembl
    3. branching involved in salivary gland morphogenesis Source: Ensembl
    4. cell growth Source: Ensembl
    5. cell redox homeostasis Source: Ensembl
    6. defense response to protozoan Source: Ensembl
    7. endocrine pancreas development Source: Ensembl
    8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    9. glucagon secretion Source: Ensembl
    10. immune response Source: InterPro
    11. interleukin-6-mediated signaling pathway Source: Ensembl
    12. muscle cell cellular homeostasis Source: Ensembl
    13. negative regulation of cell proliferation Source: Ensembl
    14. negative regulation of chemokine biosynthetic process Source: Ensembl
    15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    16. negative regulation of cytokine secretion Source: Ensembl
    17. negative regulation of gluconeogenesis Source: Ensembl
    18. negative regulation of hormone secretion Source: Ensembl
    19. negative regulation of muscle organ development Source: Ensembl
    20. negative regulation of neuron death Source: Ensembl
    21. negative regulation of protein kinase activity Source: Ensembl
    22. neutrophil apoptotic process Source: Ensembl
    23. positive regulation of DNA replication Source: Ensembl
    24. positive regulation of epithelial cell proliferation Source: Ensembl
    25. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    26. positive regulation of neuron differentiation Source: Ensembl
    27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    28. positive regulation of protein import into nucleus, translocation Source: Ensembl
    29. positive regulation of protein kinase B signaling Source: Ensembl
    30. positive regulation of T-helper 2 cell differentiation Source: Ensembl
    31. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    32. positive regulation of transmission of nerve impulse Source: Ensembl
    33. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    34. regulation of cell shape Source: Ensembl
    35. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    36. response to amino acid Source: Ensembl
    37. response to antibiotic Source: Ensembl
    38. response to caffeine Source: Ensembl
    39. response to calcium ion Source: Ensembl
    40. response to cold Source: Ensembl
    41. response to drug Source: Ensembl
    42. response to electrical stimulus Source: Ensembl
    43. response to heat Source: Ensembl
    44. response to insulin Source: Ensembl
    45. response to lipopolysaccharide Source: Ensembl
    46. response to mechanical stimulus Source: Ensembl
    47. response to nutrient levels Source: Ensembl
    48. response to wounding Source: Ensembl
    49. T cell activation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin-6Imported
    Gene namesi
    Name:IL6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:6018. IL6.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiC9J5B0.
    BgeeiC9J5B0.

    Structurei

    3D structure databases

    ProteinModelPortaliC9J5B0.
    SMRiC9J5B0. Positions 47-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000236330.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PANTHERiPTHR11457. PTHR11457. 1 hit.
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    PRINTSiPR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTiSM00126. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    C9J5B0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSFSTSAFG PVAFSLGLLL VLPAAFPAPV PPGEDSKDVA APHRQPLTSS    50
    ERIDKQIRYI LDGISALRKE TCNKSNMCES SKEALAENNL NLPKMAEKDG 100
    CFQSGFNEET CLVKIITGLL EFEVYLEYLQ NRFESSEEQA RAVQMSTKVL 150
    IQ 152
    Length:152
    Mass (Da):16,791
    Last modified:November 3, 2009 - v1
    Checksum:iEE1562147E15AF4F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei152 – 1521Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073072 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000426291; ENSP00000405150; ENSG00000136244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073072 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali C9J5B0.
    SMRi C9J5B0. Positions 47-152.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000426291 ; ENSP00000405150 ; ENSG00000136244 .

    Organism-specific databases

    HGNCi HGNC:6018. IL6.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000236330.

    Miscellaneous databases

    ChiTaRSi IL6. human.
    NextBioi 35485040.

    Gene expression databases

    ArrayExpressi C9J5B0.
    Bgeei C9J5B0.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    PANTHERi PTHR11457. PTHR11457. 1 hit.
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    PRINTSi PR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTi SM00126. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiC9J5B0_HUMAN
    AccessioniPrimary (citable) accession number: C9J5B0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3