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Protein

DNA-directed RNA polymerase subunit beta

Gene

POLR2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:POLR2BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000047315.14.
HGNCiHGNC:9188. POLR2B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047315.

PTM / Processingi

Proteomic databases

PaxDbiC9J4M6.
PeptideAtlasiC9J4M6.
PRIDEiC9J4M6.

Expressioni

Gene expression databases

BgeeiENSG00000047315.
ExpressionAtlasiC9J4M6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9J4M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 334RNA_pol_Rpb2_1InterPro annotationAdd BLAST334
Domaini94 – 287RNA_pol_Rpb2_2InterPro annotationAdd BLAST194
Domaini361 – 425RNA_pol_Rpb2_3InterPro annotationAdd BLAST65
Domaini460 – 522RNA_pol_Rpb2_4InterPro annotationAdd BLAST63
Domaini546 – 593RNA_pol_Rpb2_5InterPro annotationAdd BLAST48
Domaini600 – 973RNA_pol_Rpb2_6InterPro annotationAdd BLAST374
Domaini975 – 1065RNA_pol_Rpb2_7InterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
GeneTreeiENSGT00860000133818.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
3.90.1110.10. 1 hit.
InterProiView protein in InterPro
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiView protein in Pfam
PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
PROSITEiView protein in PROSITE
PS01166. RNA_POL_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

C9J4M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPNEARLRN LTYSAPLYVD ITKTVIKEGE EQLQTQHQKT FIGKIPIMLR
60 70 80 90 100
STYCLLNGLT DRDLCELNEC PLDPGGYFII NGSEKVLIAQ EKMATNTVYV
110 120 130 140 150
FAKKDSKYAY TGECRSCLEN SSRPTSTIWV SMLARGGQGA KKSAIGQRIV
160 170 180 190 200
ATLPYIKQEV PIIIVFRALG FVSDRDILEH IIYDFEDPEM MEMVKPSLDE
210 220 230 240 250
AFVIQEQNVA LNFIGSRGAK PGVTKEKRIK YAKEVLQKEM LPHVGVSDFC
260 270 280 290 300
ETKKAYFLGY MVHRLLLAAL GRRELDDRDH YGNKRLDLAG PLLAFLFRGM
310 320 330 340 350
FKNLLKEVRI YAQKFIDRGK DFNLELAIKT RIISDGLKYS LATGNWGDQK
360 370 380 390 400
KAHQARAGVS QVLNRLTFAS TLSHLRRLNS PIGRDGKLAK PRQLHNTLWG
410 420 430 440 450
MVCPAETPEG HAVGLVKNLA LMAYISVGSQ PSPILEFLEE WSMENLEEIS
460 470 480 490 500
PAAIADATKI FVNGCWVGIH KDPEQLMNTL RKLRRQMDII VSEVSMIRDI
510 520 530 540 550
REREIRIYTD AGRICRPLLI VEKQKLLLKK RHIDQLKERE YNNYSWQDLV
560 570 580 590 600
ASGVVEYIDT LEEETVMLAM TPDDLQEKEV AYCSTYTHCE IHPSMILGVC
610 620 630 640 650
ASIIPFPDHN QSPRNTYQSA MGKQAMGVYI TNFHVRMDTL AHVLYYPQKP
660 670 680 690 700
LVTTRSMEYL RFRELPAGIN SIVAIASYTG YNQEDSVIMN RSAVDRGFFR
710 720 730 740 750
SVFYRSYKEQ ESKKGFDQEE VFEKPTRETC QGMRHAIYDK LDDDGLIAPG
760 770 780 790 800
VRVSGDDVII GKTVTLPENE DELESTNRRY TKRDCSTFLR TSETGIVDQV
810 820 830 840 850
MVTLNQEGYK FCKIRVRSVR IPQIGDKFAS RHGQKGTCGI QYRQEDMPFT
860 870 880 890 900
CEGITPDIII NPHAIPSRMT IGHLIECLQG KVSANKGEIG DATPFNDAVN
910 920 930 940 950
VQKISNLLSD YGYHLRGNEV LYNGFTGRKI TSQIFIGPTY YQRLKHMVDD
960 970 980 990 1000
KIHSRARGPI QILNRQPMEG RSRDGGLRFG EMERDCQIAH GAAQFLRERL
1010 1020 1030 1040 1050
FEASDPYQVH VCNLCGIMAI ANTRTHTYEC RGCRNKTQIS LVRMPYACKL
1060
LFQELMSMSI APRMMSV
Length:1,067
Mass (Da):121,373
Last modified:June 7, 2017 - v3
Checksum:iD928819E9C092ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069307 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000431623; ENSP00000391096; ENSG00000047315.
UCSCiuc011caf.2. human.

Similar proteinsi

Entry informationi

Entry nameiC9J4M6_HUMAN
AccessioniPrimary (citable) accession number: C9J4M6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 7, 2017
Last modified: September 27, 2017
This is version 71 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported