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Protein

DNA-directed RNA polymerase subunit beta

Gene

POLR2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:POLR2BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9188. POLR2B.

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047315.

PTM / Processingi

Proteomic databases

MaxQBiC9J4M6.
PaxDbiC9J4M6.
PeptideAtlasiC9J4M6.
PRIDEiC9J4M6.

Expressioni

Gene expression databases

BgeeiENSG00000047315.
ExpressionAtlasiC9J4M6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312735.

Structurei

3D structure databases

ProteinModelPortaliC9J4M6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 366RNA_pol_Rpb2_1InterPro annotationAdd BLAST359
Domaini126 – 319RNA_pol_Rpb2_2InterPro annotationAdd BLAST194
Domaini393 – 457RNA_pol_Rpb2_3InterPro annotationAdd BLAST65
Domaini492 – 554RNA_pol_Rpb2_4InterPro annotationAdd BLAST63
Domaini578 – 625RNA_pol_Rpb2_5InterPro annotationAdd BLAST48
Domaini632 – 1005RNA_pol_Rpb2_6InterPro annotationAdd BLAST374
Domaini1007 – 1097RNA_pol_Rpb2_7InterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
GeneTreeiENSGT00860000133818.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J4M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDCNQPRYL LKFEQIYLSK PTHWERDGAP SPMMPNEARL RNLTYSAPLY
60 70 80 90 100
VDITKTVIKE GEEQLQTQHQ KTFIGKIPIM LRSTYCLLNG LTDRDLCELN
110 120 130 140 150
ECPLDPGGYF IINGSEKVLI AQEKMATNTV YVFAKKDSKY AYTGECRSCL
160 170 180 190 200
ENSSRPTSTI WVSMLARGGQ GAKKSAIGQR IVATLPYIKQ EVPIIIVFRA
210 220 230 240 250
LGFVSDRDIL EHIIYDFEDP EMMEMVKPSL DEAFVIQEQN VALNFIGSRG
260 270 280 290 300
AKPGVTKEKR IKYAKEVLQK EMLPHVGVSD FCETKKAYFL GYMVHRLLLA
310 320 330 340 350
ALGRRELDDR DHYGNKRLDL AGPLLAFLFR GMFKNLLKEV RIYAQKFIDR
360 370 380 390 400
GKDFNLELAI KTRIISDGLK YSLATGNWGD QKKAHQARAG VSQVLNRLTF
410 420 430 440 450
ASTLSHLRRL NSPIGRDGKL AKPRQLHNTL WGMVCPAETP EGHAVGLVKN
460 470 480 490 500
LALMAYISVG SQPSPILEFL EEWSMENLEE ISPAAIADAT KIFVNGCWVG
510 520 530 540 550
IHKDPEQLMN TLRKLRRQMD IIVSEVSMIR DIREREIRIY TDAGRICRPL
560 570 580 590 600
LIVEKQKLLL KKRHIDQLKE REYNNYSWQD LVASGVVEYI DTLEEETVML
610 620 630 640 650
AMTPDDLQEK EVAYCSTYTH CEIHPSMILG VCASIIPFPD HNQSPRNTYQ
660 670 680 690 700
SAMGKQAMGV YITNFHVRMD TLAHVLYYPQ KPLVTTRSME YLRFRELPAG
710 720 730 740 750
INSIVAIASY TGYNQEDSVI MNRSAVDRGF FRSVFYRSYK EQESKKGFDQ
760 770 780 790 800
EEVFEKPTRE TCQGMRHAIY DKLDDDGLIA PGVRVSGDDV IIGKTVTLPE
810 820 830 840 850
NEDELESTNR RYTKRDCSTF LRTSETGIVD QVMVTLNQEG YKFCKIRVRS
860 870 880 890 900
VRIPQIGDKF ASRHGQKGTC GIQYRQEDMP FTCEGITPDI IINPHAIPSR
910 920 930 940 950
MTIGHLIECL QGKVSANKGE IGDATPFNDA VNVQKISNLL SDYGYHLRGN
960 970 980 990 1000
EVLYNGFTGR KITSQIFIGP TYYQRLKHMV DDKIHSRARG PIQILNRQPM
1010 1020 1030 1040 1050
EGRSRDGGLR FGEMERDCQI AHGAAQFLRE RLFEASDPYQ VHVCNLCGIM
1060 1070 1080 1090
AIANTRTHTY ECRGCRNKTQ ISLVRMPYAC KLLFQELMSM SIAPRMMSV
Length:1,099
Mass (Da):125,189
Last modified:July 13, 2010 - v2
Checksum:iDA942594FDD792B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069307 Genomic DNA. No translation available.
RefSeqiNP_001290197.1. NM_001303268.1.
UniGeneiHs.602757.

Genome annotation databases

EnsembliENST00000431623; ENSP00000391096; ENSG00000047315.
GeneIDi5431.
UCSCiuc011caf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069307 Genomic DNA. No translation available.
RefSeqiNP_001290197.1. NM_001303268.1.
UniGeneiHs.602757.

3D structure databases

ProteinModelPortaliC9J4M6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312735.

Proteomic databases

MaxQBiC9J4M6.
PaxDbiC9J4M6.
PeptideAtlasiC9J4M6.
PRIDEiC9J4M6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431623; ENSP00000391096; ENSG00000047315.
GeneIDi5431.
UCSCiuc011caf.2. human.

Organism-specific databases

CTDi5431.
HGNCiHGNC:9188. POLR2B.
OpenTargetsiENSG00000047315.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
GeneTreeiENSGT00860000133818.

Miscellaneous databases

ChiTaRSiPOLR2B. human.
GenomeRNAii5431.

Gene expression databases

BgeeiENSG00000047315.
ExpressionAtlasiC9J4M6. baseline and differential.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9J4M6_HUMAN
AccessioniPrimary (citable) accession number: C9J4M6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.