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Protein

DNA-directed RNA polymerase subunit beta

Gene

POLR2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:POLR2BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9188. POLR2B.

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

PTM / Processingi

Proteomic databases

EPDiC9J2Y9.
PaxDbiC9J2Y9.

Expressioni

Gene expression databases

BgeeiC9J2Y9.
ExpressionAtlasiC9J2Y9. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiC9J2Y9. 12 interactions.
STRINGi9606.ENSP00000312735.

Structurei

3D structure databases

ProteinModelPortaliC9J2Y9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 434404RNA_pol_Rpb2_1InterPro annotationAdd
BLAST
Domaini194 – 387194RNA_pol_Rpb2_2InterPro annotationAdd
BLAST
Domaini461 – 52565RNA_pol_Rpb2_3InterPro annotationAdd
BLAST
Domaini560 – 62263RNA_pol_Rpb2_4InterPro annotationAdd
BLAST
Domaini646 – 69348RNA_pol_Rpb2_5InterPro annotationAdd
BLAST
Domaini700 – 1073374RNA_pol_Rpb2_6InterPro annotationAdd
BLAST
Domaini1075 – 116591RNA_pol_Rpb2_7InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
GeneTreeiENSGT00760000119346.

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J2Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYDEDDDEI TPDLWQEACW IVISSYFDEK GLVRQQLDSF DEFIQMSVQR
60 70 80 90 100
IVEDAPPIDL QAEAQHASGE VEEPPRYLLK FEQIYLSKPT HWERDGAPSP
110 120 130 140 150
MMPNEARLRN LTYSAPLYVD ITKTVIKEGE EQLQTQHQKT FIGKIPIMLR
160 170 180 190 200
STYCLLNGLT DRDLCELNEC PLDPGGYFII NGSEKVLIAQ EKMATNTVYV
210 220 230 240 250
FAKKDSKYAY TGECRSCLEN SSRPTSTIWV SMLARGGQGA KKSAIGQRIV
260 270 280 290 300
ATLPYIKQEV PIIIVFRALG FVSDRDILEH IIYDFEDPEM MEMVKPSLDE
310 320 330 340 350
AFVIQEQNVA LNFIGSRGAK PGVTKEKRIK YAKEVLQKEM LPHVGVSDFC
360 370 380 390 400
ETKKAYFLGY MVHRLLLAAL GRRELDDRDH YGNKRLDLAG PLLAFLFRGM
410 420 430 440 450
FKNLLKEVRI YAQKFIDRGK DFNLELAIKT RIISDGLKYS LATGNWGDQK
460 470 480 490 500
KAHQARAGVS QVLNRLTFAS TLSHLRRLNS PIGRDGKLAK PRQLHNTLWG
510 520 530 540 550
MVCPAETPEG HAVGLVKNLA LMAYISVGSQ PSPILEFLEE WSMENLEEIS
560 570 580 590 600
PAAIADATKI FVNGCWVGIH KDPEQLMNTL RKLRRQMDII VSEVSMIRDI
610 620 630 640 650
REREIRIYTD AGRICRPLLI VEKQKLLLKK RHIDQLKERE YNNYSWQDLV
660 670 680 690 700
ASGVVEYIDT LEEETVMLAM TPDDLQEKEV AYCSTYTHCE IHPSMILGVC
710 720 730 740 750
ASIIPFPDHN QSPRNTYQSA MGKQAMGVYI TNFHVRMDTL AHVLYYPQKP
760 770 780 790 800
LVTTRSMEYL RFRELPAGIN SIVAIASYTG YNQEDSVIMN RSAVDRGFFR
810 820 830 840 850
SVFYRSYKEQ ESKKGFDQEE VFEKPTRETC QGMRHAIYDK LDDDGLIAPG
860 870 880 890 900
VRVSGDDVII GKTVTLPENE DELESTNRRY TKRDCSTFLR TSETGIVDQV
910 920 930 940 950
MVTLNQEGYK FCKIRVRSVR IPQIGDKFAS RHGQKGTCGI QYRQEDMPFT
960 970 980 990 1000
CEGITPDIII NPHAIPSRMT IGHLIECLQG KVSANKGEIG DATPFNDAVN
1010 1020 1030 1040 1050
VQKISNLLSD YGYHLRGNEV LYNGFTGRKI TSQIFIGPTY YQRLKHMVDD
1060 1070 1080 1090 1100
KIHSRARGPI QILNRQPMEG RSRDGGLRFG EMERDCQIAH GAAQFLRERL
1110 1120 1130 1140 1150
FEASDPYQVH VCNLCGIMAI ANTRTHTYEC RGCRNKTQIS LVRMPYACKL
1160
LFQELMSMSI APRMMSV
Length:1,167
Mass (Da):133,057
Last modified:July 13, 2010 - v2
Checksum:iDD600BBDDA6BCD0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069307 Genomic DNA. No translation available.
RefSeqiNP_001290198.1. NM_001303269.1.
UniGeneiHs.602757.

Genome annotation databases

EnsembliENST00000441246; ENSP00000391452; ENSG00000047315.
GeneIDi5431.
UCSCiuc011cae.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069307 Genomic DNA. No translation available.
RefSeqiNP_001290198.1. NM_001303269.1.
UniGeneiHs.602757.

3D structure databases

ProteinModelPortaliC9J2Y9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC9J2Y9. 12 interactions.
STRINGi9606.ENSP00000312735.

Proteomic databases

EPDiC9J2Y9.
PaxDbiC9J2Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441246; ENSP00000391452; ENSG00000047315.
GeneIDi5431.
UCSCiuc011cae.2. human.

Organism-specific databases

CTDi5431.
HGNCiHGNC:9188. POLR2B.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0214. Eukaryota.
COG0085. LUCA.
GeneTreeiENSGT00760000119346.

Miscellaneous databases

ChiTaRSiPOLR2B. human.
GenomeRNAii5431.
NextBioi35484748.

Gene expression databases

BgeeiC9J2Y9.
ExpressionAtlasiC9J2Y9. baseline and differential.

Family and domain databases

Gene3Di2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
InterProiIPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007646. RNA_pol_Rpb2_4.
IPR007647. RNA_pol_Rpb2_5.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF04566. RNA_pol_Rpb2_4. 1 hit.
PF04567. RNA_pol_Rpb2_5. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC9J2Y9_HUMAN
AccessioniPrimary (citable) accession number: C9J2Y9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: July 13, 2010
Last modified: May 11, 2016
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.