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C9J2U0

- C9J2U0_HUMAN

UniProt

C9J2U0 - C9J2U0_HUMAN

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Protein
Submitted name:

Cyclin E variant ex7del

Gene

CCNE1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: InterPro
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotation

Enzyme and pathway databases

SignaLinkiC9J2U0.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin E variant ex7delImported
Submitted name:
G1/S-specific cyclin-E1Imported
Gene namesi
Name:CCNE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1589. CCNE1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiC9J2U0.

Expressioni

Gene expression databases

BgeeiC9J2U0.

Structurei

3D structure databases

ProteinModelPortaliC9J2U0.
SMRiC9J2U0. Positions 103-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000231743.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 2 hits.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J2U0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEDGGAEFS ARSRKRKANV TVFLQDPDEE MAKIDRTARD QCGSQPWDNN
60 70 80 90 100
AVCADPCSLI PTPDKEDDDR VYPNSTCKPR IIAPSRGSPL PVLSWANREE
110 120 130 140 150
VWKIMLNKEK TYLRDQHFLE QHPLLQPKMR AILLDWLMEV CEVYKLHRET
160 170 180 190 200
FYLAQDFFDR YMATQENVVK TLLQLIGISS LFIAAKLEEI YPPKLHQFAY
210 220 230 240 250
VTDGACSGDE ILTMELMIMK LLDLCVLDVD CLEFPYGILA ASALYHFSSS
260 270 280 290 300
ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR GVADEDAHNI
310 320 330 340 350
QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG KKQSSGPEMA
Length:350
Mass (Da):39,812
Last modified:October 29, 2014 - v3
Checksum:iDA4FAE0D8859781F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008798 Genomic DNA. No translation available.
KF672847 mRNA. Translation: AHC02488.1.
UniGeneiHs.244723.

Genome annotation databases

EnsembliENST00000357943; ENSP00000350625; ENSG00000105173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008798 Genomic DNA. No translation available.
KF672847 mRNA. Translation: AHC02488.1 .
UniGenei Hs.244723.

3D structure databases

ProteinModelPortali C9J2U0.
SMRi C9J2U0. Positions 103-329.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi C9J2U0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357943 ; ENSP00000350625 ; ENSG00000105173 .

Organism-specific databases

HGNCi HGNC:1589. CCNE1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118939.
HOGENOMi HOG000231743.

Enzyme and pathway databases

SignaLinki C9J2U0.

Miscellaneous databases

NextBioi 35484733.

Gene expression databases

Bgeei C9J2U0.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF71. PTHR10177:SF71. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 2 hits.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  6. "Identification and annotation of alternative forms of cyclin E in bladder tumors."
    Kohaar I., Fu Y.-P., Tang W., Porter-Gill P., Prokunina-Olsson L.
    Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC9J2U0_HUMAN
AccessioniPrimary (citable) accession number: C9J2U0
Secondary accession number(s): V5W643
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: October 29, 2014
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3