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Protein
Submitted name:

Cyclin E variant ex7del

Gene

CCNE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: InterPro
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

CyclinUniRule annotation

Enzyme and pathway databases

SignaLinkiC9J2U0.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin E variant ex7delImported
Submitted name:
G1/S-specific cyclin-E1Imported
Gene namesi
Name:CCNE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1589. CCNE1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiC9J2U0.

Expressioni

Gene expression databases

BgeeiC9J2U0.

Structurei

3D structure databases

ProteinModelPortaliC9J2U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000231743.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J2U0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEDGGAEFS ARSRKRKANV TVFLQDPDEE MAKIDRTARD QCGSQPWDNN
60 70 80 90 100
AVCADPCSLI PTPDKEDDDR VYPNSTCKPR IIAPSRGSPL PVLSWANREE
110 120 130 140 150
VWKIMLNKEK TYLRDQHFLE QHPLLQPKMR AILLDWLMEV CEVYKLHRET
160 170 180 190 200
FYLAQDFFDR YMATQENVVK TLLQLIGISS LFIAAKLEEI YPPKLHQFAY
210 220 230 240 250
VTDGACSGDE ILTMELMIMK LLDLCVLDVD CLEFPYGILA ASALYHFSSS
260 270 280 290 300
ELMQKVSGYQ WCDIENCVKW MVPFAMVIRE TGSSKLKHFR GVADEDAHNI
310 320 330 340 350
QTHRDSLDLL DKARAKKAML SEQNRASPLP SGLLTPPQSG KKQSSGPEMA
Length:350
Mass (Da):39,812
Last modified:October 29, 2014 - v3
Checksum:iDA4FAE0D8859781F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008798 Genomic DNA. No translation available.
KF672847 mRNA. Translation: AHC02488.1.
UniGeneiHs.244723.

Genome annotation databases

EnsembliENST00000357943; ENSP00000350625; ENSG00000105173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008798 Genomic DNA. No translation available.
KF672847 mRNA. Translation: AHC02488.1.
UniGeneiHs.244723.

3D structure databases

ProteinModelPortaliC9J2U0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC9J2U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357943; ENSP00000350625; ENSG00000105173.

Organism-specific databases

HGNCiHGNC:1589. CCNE1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118939.
HOGENOMiHOG000231743.

Enzyme and pathway databases

SignaLinkiC9J2U0.

Miscellaneous databases

ChiTaRSiCCNE1. human.
NextBioi35484733.

Gene expression databases

BgeeiC9J2U0.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR028858. Cyclin_E.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF71. PTHR10177:SF71. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Identification and annotation of alternative forms of cyclin E in bladder tumors."
    Kohaar I., Fu Y.-P., Tang W., Porter-Gill P., Prokunina-Olsson L.
    Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC9J2U0_HUMAN
AccessioniPrimary (citable) accession number: C9J2U0
Secondary accession number(s): V5W643
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 29, 2014
Last modified: February 4, 2015
This is version 47 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.