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C9J258

- C9J258_HUMAN

UniProt

C9J258 - C9J258_HUMAN

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Protein
Submitted name:

RAC-beta serine/threonine-protein kinase

Gene

AKT2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  1. activation of Ral GTPase activity Source: Ensembl
  2. insulin receptor signaling pathway Source: Ensembl
  3. intracellular protein transmembrane transport Source: Ensembl
  4. peripheral nervous system myelin maintenance Source: Ensembl
  5. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  6. positive regulation of protein phosphorylation Source: Ensembl
  7. positive regulation of protein targeting to membrane Source: Ensembl
  8. positive regulation of vesicle fusion Source: Ensembl
  9. protein localization to plasma membrane Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
RAC-beta serine/threonine-protein kinaseImported
Gene namesi
Name:AKT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:392. AKT2.

Subcellular locationi

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. ruffle membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiC9J258.
ExpressionAtlasiC9J258. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00770000120449.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9J258-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP
60 70 80 90
PLNNFSVAEC QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDE
Length:95
Mass (Da):11,270
Last modified:October 3, 2012 - v2
Checksum:i0EEF6D7BFC55D7FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei95 – 951Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118344 Genomic DNA. No translation available.
KC877734 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000416994; ENSP00000392458; ENSG00000105221.
ENST00000580747; ENSP00000463806; ENSG00000105221.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118344 Genomic DNA. No translation available.
KC877734 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi C9J258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000416994 ; ENSP00000392458 ; ENSG00000105221 .
ENST00000580747 ; ENSP00000463806 ; ENSG00000105221 .

Organism-specific databases

HGNCi HGNC:392. AKT2.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00770000120449.

Miscellaneous databases

ChiTaRSi AKT2. human.
NextBioi 35484650.
35536781.

Gene expression databases

Bgeei C9J258.
ExpressionAtlasi C9J258. baseline and differential.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC9J258_HUMAN
AccessioniPrimary (citable) accession number: C9J258
Secondary accession number(s): J3QQM6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3