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Protein
Submitted name:

Activated CDC42 kinase 1

Gene

TNK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Activated CDC42 kinase 1Imported
Gene namesi
Name:TNK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19297. TNK2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000061938.

PTM / Processingi

Proteomic databases

MaxQBiC9J1X3.
PaxDbiC9J1X3.
PRIDEiC9J1X3.

Expressioni

Gene expression databases

BgeeiENSG00000061938.
ExpressionAtlasiC9J1X3. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiC9J1X3. 1 interactor.
STRINGi9606.ENSP00000371341.

Structurei

3D structure databases

ProteinModelPortaliC9J1X3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 417Protein kinaseInterPro annotationAdd BLAST260
Domaini405 – 480SH3InterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

eggNOGiKOG0199. Eukaryota.
ENOG410XPRC. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000168225.

Family and domain databases

Gene3Di4.10.680.10. 1 hit.
InterProiIPR015116. Cdc42_binding_dom-like.
IPR011009. Kinase-like_dom.
IPR021619. Mig-6.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF09027. GTPase_binding. 1 hit.
PF11555. Inhibitor_Mig-6. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C9J1X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAARRFPGL ELSFPLLARL RRRLYTRLGG GRMQPEEGTG WLLELLSEVQ
60 70 80 90 100
LQQYFLRLRD DLNVTRLSHF EYVKNEDLEK IGMGRPGQRR LWEAVKRRKA
110 120 130 140 150
LCKRKSWMSK VFSGKRLEAE FPPHHSQSTF RKTSPAPGGP AGEGPLQSLT
160 170 180 190 200
CLIGEKDLRL LEKLGDGSFG VVRRGEWDAP SGKTVSVAVK CLKPDVLSQP
210 220 230 240 250
EAMDDFIREV NAMHSLDHRN LIRLYGVVLT PPMKMVTELA PLGSLLDRLR
260 270 280 290 300
KHQGHFLLGT LSRYAVQVAE GMGYLESKRF IHRDLAARNL LLATRDLVKI
310 320 330 340 350
GDFGLMRALP QNDDHYVMQE HRKVPFAWCA PESLKTRTFS HASDTWMFGV
360 370 380 390 400
TLWEMFTYGQ EPWIGLNGSQ ILHKIDKEGE RLPRPEDCPQ DIYNVMVQCW
410 420 430 440 450
AHKPEDRPTF VALRDFLLEA QPTDMRALQD FEEPDKLHIQ MNDVITVIEG
460 470 480 490 500
RAENYWWRGQ NTRTLCVGPF PRNVVTSVAG LSAQDISQPL QNSFIHTGHG
510 520 530 540 550
DSDPRHCWGF PDRIDELYLG NPMDPPDLLS VELSTSRPPQ HLGGVKKPTY
560 570 580 590 600
DPVSEDQDPL SSDFKRLGLR KPGLPRGLWL AKPSARVPGT KASRGSGAEV
610 620 630 640 650
TLIDFGEEPV VPALRPCAPS LAQLAMDACS LLDETPPQSP TRALPRPLHP
660 670 680 690 700
TPVVDWDARP LPPPPAYDDV AQDEDDFEIC SINSTLVGAG VPAGPSQGQT
710 720 730 740 750
NYAFVPEQAR PPPPLEDNLF LPPQGGGKPP SSAQTAEIFQ ALQQECMRQL
760 770 780 790 800
QAPAGSPAPS PSPGGDDKPQ VPPRVPIPPR PTRPHVQLSP APPGEEETSQ
810 820 830 840 850
WPGPASPPRV PPREPLSPQG SRTPSPLVPP GSSPLPPRLS SSPGKTMPTT
860 870 880 890 900
QSFASDPKYA TPQVIQAPGP RAGPCILPIV RDGKKVSSTH YYLLPERPSY
910 920 930 940 950
LERYQRFLRE AQSPEEPTPL PVPLLLPPPS TPAPAAPTAT VRPMPQAALD
960 970 980 990 1000
PKANFSTNNS NPGARPPPPR ATARLPQRGC PGDGPEAGRP ADKIQMVEQL
1010 1020 1030 1040
FGLGLRPRGE CHKVLEMFDW NLEQAGCHLL GSWGPAHHKR
Length:1,040
Mass (Da):114,950
Last modified:November 3, 2009 - v1
Checksum:iC2E28B9C4BBCF45F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124944 Genomic DNA. No translation available.
RefSeqiNP_001294975.1. NM_001308046.1.
UniGeneiHs.518513.

Genome annotation databases

EnsembliENST00000428187; ENSP00000392546; ENSG00000061938.
GeneIDi10188.
UCSCiuc003fvs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124944 Genomic DNA. No translation available.
RefSeqiNP_001294975.1. NM_001308046.1.
UniGeneiHs.518513.

3D structure databases

ProteinModelPortaliC9J1X3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC9J1X3. 1 interactor.
STRINGi9606.ENSP00000371341.

Proteomic databases

MaxQBiC9J1X3.
PaxDbiC9J1X3.
PRIDEiC9J1X3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000428187; ENSP00000392546; ENSG00000061938.
GeneIDi10188.
UCSCiuc003fvs.2. human.

Organism-specific databases

CTDi10188.
HGNCiHGNC:19297. TNK2.
OpenTargetsiENSG00000061938.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0199. Eukaryota.
ENOG410XPRC. LUCA.
GeneTreeiENSGT00760000118799.
HOGENOMiHOG000168225.

Miscellaneous databases

ChiTaRSiTNK2. human.
GenomeRNAii10188.

Gene expression databases

BgeeiENSG00000061938.
ExpressionAtlasiC9J1X3. baseline and differential.

Family and domain databases

Gene3Di4.10.680.10. 1 hit.
InterProiIPR015116. Cdc42_binding_dom-like.
IPR011009. Kinase-like_dom.
IPR021619. Mig-6.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF09027. GTPase_binding. 1 hit.
PF11555. Inhibitor_Mig-6. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9J1X3_HUMAN
AccessioniPrimary (citable) accession number: C9J1X3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: November 3, 2009
Last modified: November 30, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.