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Protein
Submitted name:

Mismatch repair endonuclease PMS2

Gene

PMS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mismatch repair endonuclease PMS2Imported
Gene namesi
Name:PMS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9122. PMS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiC9J167.
PaxDbiC9J167.

Expressioni

Gene expression databases

BgeeiC9J167.
ExpressionAtlasiC9J167. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265849.

Structurei

3D structure databases

ProteinModelPortaliC9J167.
SMRiC9J167. Positions 11-259, 552-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 258138DNA_mis_repairInterPro annotationAdd
BLAST
Domaini572 – 716145MutL_CInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1978. Eukaryota.
COG0323. LUCA.
GeneTreeiENSGT00530000063289.
HOGENOMiHOG000165474.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF39. PTHR10073:SF39. 2 hits.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

C9J167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGRRRKLRR LNDVTISTCH ASAKVGTRLM FDHNGKIIQK TPYPRPRGTT
60 70 80 90 100
VSVQQLFSTL PVRHKEFQRN IKKEYAKMVQ VLHAYCIISA GIRVSCTNQL
110 120 130 140 150
GQGKRQPVVC TGGSPSIKEN IGSVFGQKQL QSLIPFVQLP PSDSVCEEYG
160 170 180 190 200
LSCSDALHNL FYISGFISQC THGVGRSSTD RQFFFINRRP CDPAKVCRLV
210 220 230 240 250
NEVYHMYNRH QYPFVVLNIS VDSECVDINV TPDKRQILLQ EEKLLLAVLK
260 270 280 290 300
TSLIGMFDSD VNKLNVSQQP LLDVEGNLIK MHAADLEKPM VEKQDQSPSL
310 320 330 340 350
RTGEEKKDVS ISRLREAFSL RHTTENKPHS PKTPEPRRSP LGQKRGMLSS
360 370 380 390 400
STSGAISDKG VLRPQKEAVS SSHGPSDPTD RAEVEKDSGH GSTSVDSEGF
410 420 430 440 450
SIPDTGSHCS SEYAASSPGD RGSQEHVDSQ EKAPKTDDSF SDVDCHSNQE
460 470 480 490 500
DTGCKFRVLP QPTNLATPNT KRFKKEEILS SSDICQKLVN TQDMSASQVD
510 520 530 540 550
VAVKINKKVV PLDFSMSSLA KRIKQLHHEA QQSEGEQNYR KFRAKICPGE
560 570 580 590 600
NQAAEDELRK EISKTMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK
610 620 630 640 650
YNFEMLQQHT VLQGQRLIAP QTLNLTAVNE AVLIENLEIF RKNGFDFVID
660 670 680 690 700
ENAPVTERAK LISLPTSKNW TFGPQDVDEL IFMLSDSPGV MCRPSRVKQM
710 720 730 740 750
FASRACRKSV MIGTALNTSE MKKLITHMGE MDHPWNCPHG RPTMRHIANL

GVISQN
Length:756
Mass (Da):84,697
Last modified:June 28, 2011 - v2
Checksum:i48E5D50BD3428966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005995 Genomic DNA. No translation available.
RefSeqiXP_011513732.1. XM_011515430.1.
UniGeneiHs.632637.
Hs.715590.

Genome annotation databases

EnsembliENST00000441476; ENSP00000392843; ENSG00000122512.
GeneIDi5395.
UCSCiuc064bft.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005995 Genomic DNA. No translation available.
RefSeqiXP_011513732.1. XM_011515430.1.
UniGeneiHs.632637.
Hs.715590.

3D structure databases

ProteinModelPortaliC9J167.
SMRiC9J167. Positions 11-259, 552-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265849.

Proteomic databases

EPDiC9J167.
PaxDbiC9J167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000441476; ENSP00000392843; ENSG00000122512.
GeneIDi5395.
UCSCiuc064bft.1. human.

Organism-specific databases

CTDi5395.
HGNCiHGNC:9122. PMS2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1978. Eukaryota.
COG0323. LUCA.
GeneTreeiENSGT00530000063289.
HOGENOMiHOG000165474.

Miscellaneous databases

GenomeRNAii5395.

Gene expression databases

BgeeiC9J167.
ExpressionAtlasiC9J167. baseline and differential.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF39. PTHR10073:SF39. 2 hits.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC9J167_HUMAN
AccessioniPrimary (citable) accession number: C9J167
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 28, 2011
Last modified: June 8, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.