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Protein
Submitted name:

Mismatch repair endonuclease PMS2

Gene

PMS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Mismatch repair endonuclease PMS2Imported
Gene namesi
Name:PMS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122512.14.
HGNCiHGNC:9122. PMS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122512.

PTM / Processingi

Proteomic databases

MaxQBiC9J167.
PaxDbiC9J167.
PeptideAtlasiC9J167.
PRIDEiC9J167.

Expressioni

Gene expression databases

BgeeiENSG00000122512.
ExpressionAtlasiC9J167. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliC9J167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 258DNA_mis_repairInterPro annotationAdd BLAST138
Domaini572 – 716MutL_CInterPro annotationAdd BLAST145

Phylogenomic databases

eggNOGiKOG1978. Eukaryota.
COG0323. LUCA.
GeneTreeiENSGT00530000063289.
HOGENOMiHOG000165474.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR013507. DNA_mismatch_repair_C.
IPR036890. HATPase_C_sf.
IPR014790. MutL_C.
IPR037198. MutL_C_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
SMARTiView protein in SMART
SM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
SUPFAMiSSF118116. SSF118116. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

C9J167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGRRRKLRR LNDVTISTCH ASAKVGTRLM FDHNGKIIQK TPYPRPRGTT
60 70 80 90 100
VSVQQLFSTL PVRHKEFQRN IKKEYAKMVQ VLHAYCIISA GIRVSCTNQL
110 120 130 140 150
GQGKRQPVVC TGGSPSIKEN IGSVFGQKQL QSLIPFVQLP PSDSVCEEYG
160 170 180 190 200
LSCSDALHNL FYISGFISQC THGVGRSSTD RQFFFINRRP CDPAKVCRLV
210 220 230 240 250
NEVYHMYNRH QYPFVVLNIS VDSECVDINV TPDKRQILLQ EEKLLLAVLK
260 270 280 290 300
TSLIGMFDSD VNKLNVSQQP LLDVEGNLIK MHAADLEKPM VEKQDQSPSL
310 320 330 340 350
RTGEEKKDVS ISRLREAFSL RHTTENKPHS PKTPEPRRSP LGQKRGMLSS
360 370 380 390 400
STSGAISDKG VLRPQKEAVS SSHGPSDPTD RAEVEKDSGH GSTSVDSEGF
410 420 430 440 450
SIPDTGSHCS SEYAASSPGD RGSQEHVDSQ EKAPKTDDSF SDVDCHSNQE
460 470 480 490 500
DTGCKFRVLP QPTNLATPNT KRFKKEEILS SSDICQKLVN TQDMSASQVD
510 520 530 540 550
VAVKINKKVV PLDFSMSSLA KRIKQLHHEA QQSEGEQNYR KFRAKICPGE
560 570 580 590 600
NQAAEDELRK EISKTMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK
610 620 630 640 650
YNFEMLQQHT VLQGQRLIAP QTLNLTAVNE AVLIENLEIF RKNGFDFVID
660 670 680 690 700
ENAPVTERAK LISLPTSKNW TFGPQDVDEL IFMLSDSPGV MCRPSRVKQM
710 720 730 740 750
FASRACRKSV MIGTALNTSE MKKLITHMGE MDHPWNCPHG RPTMRHIANL

GVISQN
Length:756
Mass (Da):84,697
Last modified:June 28, 2011 - v2
Checksum:i48E5D50BD3428966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005995 Genomic DNA. No translation available.
RefSeqiNP_001308936.1. NM_001322007.1.
NP_001308937.1. NM_001322008.1.
UniGeneiHs.632637.
Hs.715590.

Genome annotation databases

EnsembliENST00000441476; ENSP00000392843; ENSG00000122512.
GeneIDi5395.
UCSCiuc064bft.1. human.

Similar proteinsi

Entry informationi

Entry nameiC9J167_HUMAN
AccessioniPrimary (citable) accession number: C9J167
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported