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Protein
Submitted name:

Glutamine--tRNA ligase

Gene

QARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamine--tRNA ligaseImported
Gene namesi
Name:QARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9751. QARS.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172053.

PTM / Processingi

Proteomic databases

MaxQBiC9J165.
PeptideAtlasiC9J165.
PRIDEiC9J165.

Expressioni

Gene expression databases

BgeeiENSG00000172053.
ExpressionAtlasiC9J165. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 88tRNA_synt_1c_R1InterPro annotationAdd BLAST82
Domaini130 – 204tRNA_synt_1c_R1InterPro annotationAdd BLAST75
Domaini207 – 298tRNA_synt_1c_R2InterPro annotationAdd BLAST92
Domaini305 – 338tRNA-synt_1cInterPro annotationAdd BLAST34

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074972.
HOGENOMiHOG000170323.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF04558. tRNA_synt_1c_R1. 2 hits.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

C9J165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK
60 70 80 90 100
ATGILLYGLA SRLRDTRRLS FLVSYIASKK IHTEPQLSGW WCQGLTFQEA
110 120 130 140 150
RLSLEFHEIR TLSVHFLEQR CHKLTGSFFS AALEYVRSHP LDPIDTVDFE
160 170 180 190 200
RECGVGVIVT PEQIEEAVEA AINRHRPQLL VERYHFNMGL LMGEARAVLK
210 220 230 240 250
WADGKMIKNE VDMQVLHLLG PKLEADLEKK FKVAKARLEE TDRRTAKDVV
260 270 280 290 300
ENGETADQTL SLMEQLRGEA LKFHKPGENY KTPGYVVTPH TMNLLKQHLE
310 320 330
ITGGQVRTRF PPEPNGILHI GHAKAINFNF GYAKANNGI
Length:339
Mass (Da):38,056
Last modified:February 17, 2016 - v2
Checksum:i531F9ED6C1AD496B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei339Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135506 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000452739; ENSP00000392850; ENSG00000172053.
UCSCiuc062jqp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135506 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiC9J165.
PeptideAtlasiC9J165.
PRIDEiC9J165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452739; ENSP00000392850; ENSG00000172053.
UCSCiuc062jqp.1. human.

Organism-specific databases

HGNCiHGNC:9751. QARS.
OpenTargetsiENSG00000172053.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074972.
HOGENOMiHOG000170323.

Miscellaneous databases

ChiTaRSiQARS. human.

Gene expression databases

BgeeiENSG00000172053.
ExpressionAtlasiC9J165. baseline and differential.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR007638. Gln-tRNA-synth_Ib_RNA-bd_2.
IPR007639. Gln-tRNA-synth_Ib_RNA-bd_N.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF04558. tRNA_synt_1c_R1. 2 hits.
PF04557. tRNA_synt_1c_R2. 1 hit.
[Graphical view]
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC9J165_HUMAN
AccessioniPrimary (citable) accession number: C9J165
Entry historyi
Integrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: February 17, 2016
Last modified: November 30, 2016
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.