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Protein
Submitted name:

Glutamine--tRNA ligase

Gene

QARS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamine--tRNA ligaseImported
Gene namesi
Name:QARSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172053.15
HGNCiHGNC:9751 QARS

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172053

PTM / Processingi

Proteomic databases

EPDiC9J165
PeptideAtlasiC9J165
PRIDEiC9J165

Expressioni

Gene expression databases

BgeeiENSG00000172053
ExpressionAtlasiC9J165 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 88tRNA_synt_1c_R1InterPro annotationAdd BLAST82
Domaini130 – 204tRNA_synt_1c_R1InterPro annotationAdd BLAST75
Domaini207 – 298tRNA_synt_1c_R2InterPro annotationAdd BLAST92
Domaini305 – 338tRNA-synt_1cInterPro annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili224 – 244Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074972
HOGENOMiHOG000170323

Family and domain databases

Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR007638 Gln-tRNA-synth_Ib_RNA-bd_2
IPR007639 Gln-tRNA-synth_Ib_RNA-bd_N
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF04558 tRNA_synt_1c_R1, 2 hits
PF04557 tRNA_synt_1c_R2, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Fragment.

C9J165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK
60 70 80 90 100
ATGILLYGLA SRLRDTRRLS FLVSYIASKK IHTEPQLSGW WCQGLTFQEA
110 120 130 140 150
RLSLEFHEIR TLSVHFLEQR CHKLTGSFFS AALEYVRSHP LDPIDTVDFE
160 170 180 190 200
RECGVGVIVT PEQIEEAVEA AINRHRPQLL VERYHFNMGL LMGEARAVLK
210 220 230 240 250
WADGKMIKNE VDMQVLHLLG PKLEADLEKK FKVAKARLEE TDRRTAKDVV
260 270 280 290 300
ENGETADQTL SLMEQLRGEA LKFHKPGENY KTPGYVVTPH TMNLLKQHLE
310 320 330
ITGGQVRTRF PPEPNGILHI GHAKAINFNF GYAKANNGI
Length:339
Mass (Da):38,056
Last modified:February 17, 2016 - v2
Checksum:i531F9ED6C1AD496B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei339Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135506 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000452739; ENSP00000392850; ENSG00000172053
UCSCiuc062jqp.1 human

Similar proteinsi

Entry informationi

Entry nameiC9J165_HUMAN
AccessioniPrimary (citable) accession number: C9J165
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: February 17, 2016
Last modified: April 25, 2018
This is version 60 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health